Necrosulfonamide - 10mM in DMSO , CAS No.1360614-48-7

CAS: 1360614-48-7 Cat. No.: N408273 Fórmula: C₁₈H₁₅N₅O₆S₂ Peso molecular: 461.47

GRADE & PURITY 10mM in DMSO

Synonyms

2-​Propenamide, N-​[4-​[[(3-​methoxy-​2-​pyrazinyl)​amino]​sulfonyl]​phenyl]​-​3-​(5-​nitro-​2-​thienyl)​-​, (2E)​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Necrosulfonamide Necrosulfonamide is a very specific and potent necrosis inhibitor and blocks mixed lineage kinase domain-like protein (MLKL).
In vitro

Necrosulfonamide inhibits MLKL-mediated Necrosis by blocking its N-terminal CC domain function. It blocks necrosis downstream of RIP3 activation. Necrosulfonamide has no effect on apoptosis induced by TNF-α plus Smac mimetic in non-RIP3-expressing Panc-1 cells, even at 5 μM concentration. Necrosulfonamide efficiently blocks necrosis in human cells, but not mouse cells. The reason for the species specificity of necrosulfonamide is that the cysteine at residue 86 in human MLKL that is covalently modified by necrosulfonamide is replaced by a tryptophan residue in mouse MLKL(mixed lineage kinase domain-like protein).

In vivo

Cell Data

cell lines：

Concentrations：1 μM

Incubation Time：8 or 12 hrs

Powder Purity:≥99%

Specifications

Sinónimos

2-​Propenamide, N-​[4-​[[(3-​methoxy-​2-​pyrazinyl)​amino]​sulfonyl]​phenyl]​-​3-​(5-​nitro-​2-​thienyl)​-​, (2E)​-

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Necrosulfonamide is a very specific and potent necrosis inhibitor and blocks mixed lineage kinase domain-like protein (MLKL).

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Nombres e identificadores

Isómeros SMILES

COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)/C=C/C3=CC=C(S3)[N+](=O)[O-]

Peso molecular

461.47

Reaxy-Rn

30088938

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30088938&ln=

Propiedades químicas y físicas

• Punto de fusión (°C): 257 °C(dec.)

Preguntas frecuentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1360614-48-7, the molecular formula is C18H15N5O6S2, and the molecular weight is 461.47 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.