≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Conservar a -20°C Ships Hielera + almohadillas de hielo Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Se envía a temperatura ambiente. Almacenar a -20°C.
R-7050 es un antagonista de la señalización del receptor del TNF-α.
El TNF-α induce actividad biológica mediante la estimulación del receptor del factor de necrosis tumoral. Aunque numerosas pruebas preclínicas y clínicas sugieren un papel perjudicial, las moléculas pequeñas inhibidoras de la vía de señalización del TNF-α siguen estando en gran medida inexploradas en el contexto de una hemorragia cerebral.
In vitro: R-7050 se identificó como un inhibidor selectivo de la señalización celular inducida por TNF-α mediante un cribado diferencial de bibliotecas. A diferencia de los inhibidores biológicos del TNF que se unen directamente al TNF-α, R-7050 no pudo afectar a la unión del TNF-α al TNFR. En cambio, R-7050 fue capaz de inhibir selectivamente la asociación del receptor del TNF con moléculas adaptadoras intracelulares
In vivo:
En un estudio animal previo, se probó R-7050 para atenuar la lesión neurovascular tras una hemorragia intracerebral (HIC) en ratones. Los resultados mostraron que la administración de R-7050 hasta 2 horas después de la lesión podía reducir significativamente la apertura de la barrera hematoencefálica y atenuar el desarrollo de edema a las 24 horas después de la HIC. Además, los resultados neurológicos también mejoraron durante los 3 primeros días tras la lesión. Sin embargo, no se observó que R-7050 fuera capaz de reducir el volumen del hematoma, lo que indica que los efectos beneficiosos de la inhibición del TNFR se produjeron después de la formación/resolución del coágulo.
Ensayo clínico:
Hasta la fecha, R-7050 se encuentra en fase de desarrollo preclínico.
| Pubchem Sid | 504760516 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504760516 |
| Sonrisas canónicas | C1=CC=C(C=C1)SC2=NC3=C(C=C(C=C3)Cl)N4C2=NN=C4C(F)(F)F |
| IUPAC Name | 8-chloro-4-phenylsulfanyl-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline |
| InChIKey | SUUMKHOVGVYGOP-UHFFFAOYSA-N |
| INCHI | 1S/C16H8ClF3N4S/c17-9-6-7-11-12(8-9)24-13(22-23-15(24)16(18,19)20)14(21-11)25-10-4-2-1-3-5-10/h1-8H |
| Isómeros SMILES | C1=CC=C(C=C1)SC2=NC3=C(C=C(C=C3)Cl)N4C2=NN=C4C(F)(F)F |
| PubChem CID | 1486608 |
| Peso molecular | 380.77 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organosulfur compounds |
| Clase | Thioethers |
| Subclass | Aryl thioethers |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Diarylthioethers |
| Alternative Parents | Quinoxalines Thiophenol ethers Pyrazines Benzene and substituted derivatives Aryl chlorides Triazoles Heteroaromatic compounds Sulfenyl compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organofluorides Organochlorides Hydrocarbon derivatives Alkyl fluorides |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Diarylthioether - Diazanaphthalene - Quinoxaline - Thiophenol ether - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Pyrazine - Benzenoid - 1,2,4-triazole - Azole - Heteroaromatic compound - Sulfenyl compound - Organoheterocyclic compound - Azacycle - Organopnictogen compound - Organic nitrogen compound - Alkyl fluoride - Organonitrogen compound - Organofluoride - Organochloride - Organohalogen compound - Alkyl halide - Hydrocarbon derivative - Aromatic heteropolycyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as diarylthioethers. These are organosulfur compounds containing a thioether group that is substituted by two aryl groups. |
| External Descriptors | Not available |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 A2312327 | Certificate of Analysis | Jul 10, 2024 | R276233 |
| A2312398 | Certificate of Analysis | Jul 10, 2024 | R276233 |
| A2312400 | Certificate of Analysis | Jul 10, 2024 | R276233 |
| A2312365 | Certificate of Analysis | Jul 02, 2024 | R276233 |
| A2312305 | Certificate of Analysis | Jul 02, 2024 | R276233 |
| Solubilidad | Soluble\xa0in dimethyl formamide to 25 mM |
|---|---|
| Peso molecular | 380.800 g/mol |
| XLogP3 | 5.500 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 2 |
| Exact Mass | 380.011 Da |
| Monoisotopic Mass | 380.011 Da |
| Topological Polar Surface Area | 68.400 Ų |
| Heavy Atom Count | 25 |
| Formal Charge | 0 |
| Complexity | 477.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
