Tacedinaline (CI994) - Moligand™, 10mM in DMSO , Histone deacetylase inhibitor, CAS No.112522-64-2, Histone deacetylase inhibitor

CAS: 112522-64-2 Cat. No.: T407867 Fórmula: C₁₅H₁₅N₃O₂ Peso molecular: 269.3 Número EC: 631-226-3

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

PD-123654, GOE-5549, Acetyldinaline | Benzamide, 4-(acetylamino)-N-(2-aminophenyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Tacedinaline (CI994, PD-123654, GOE-5549, Acetyldinaline) is a selective class IHDACinhibitor withIC50of 0.9, 0.9, 1.2, and >20 μM for human HDAC 1, 2, 3, and 8, respectively. Phase 3.
In vitro

CI-994 (< 160 mM) shows cytostatic effect with concomitant increase at G0/G1 phase, a reduction at S phase level and increased apoptosis in A-549 and LX-1 cells. CI-994 inhibits growth of LNCaP cell with IC50 of 7.4 μM. CI-994 exerts activity against several tumor cell lines with greater cytotoxicity against the solid tumors relative to both the leukemia and normal fibroblast cell lines. CI-994 inhibits growth of rat leukemia BCLO cells with IC50 of 2.5 μM.

In vivo

CI-994 exerts demonstrated antitumor activity against several tumor models, including the chemo-resistant mouse pancreatic ductal carcinoma as well as the human prostate tumor model LNCaP.
Cell Data

cell lines：

Concentrations：2.5 μM

Incubation Time：2-4 days

Powder Purity:≥99%

Specifications

Sinónimos

PD-123654, GOE-5549, Acetyldinaline | Benzamide, 4-(acetylamino)-N-(2-aminophenyl)-

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Tacedinaline (CI994, PD-123654, GOE-5549, Acetyldinaline) is a selective class I HDAC inhibitor with IC50 of 0.9, 0.9, 1.2, and >20 μM for human HDAC 1, 2, 3, and 8, respectively. Phase 3.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Histone deacetylase inhibitor

Propiedades del producto

• ALogP: 1.3

Nombres e identificadores

• Isómeros SMILES: CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N
• WGK Alemania: 3
• RTECS: CU8702023
• Peso molecular: 269.3
• Reaxy-Rn: 8422586
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8422586&ln=

Objetivos asociados (humanos)

HDAC1 Tclin Histone deacetylase 1 (8 Activities)

Discover Target: HDAC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC2 Tclin Histone deacetylase 2 (5 Activities)

Discover Target: HDAC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC3 Tclin Histone deacetylase 3 (3 Activities)

Discover Target: HDAC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 42.6 mg/mL (124.41 mM)
• Punto de fusión (°C): 242 °C(dec.)