2-Hydroxychalcone - Moligand™, 10 mM in DMSO , CAS No.644-78-0

CAS: 644-78-0 Cat. No.: H1495233 Molecular Weight: 224.26 Beilstein Registry Number: 8(4)1388 EC Number: 211-422-1

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Protected from light,Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Protected from light, Argon charged, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Isomeric SMILES: C1=CC=C(C=C1)C(=O)/C=C/C2=CC=CC=C2O
• Molecular Weight: 224.26
• Beilstein: 8(4)1388
• Reaxy-Rn: 147424
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=147424&ln=

Chemical and Physical Properties

• Melt Point(°C): ca 154° dec.

References

1. Jianglin Zhang, Fan Yang, Xia Sun, Lingyu Gao, Jing Yan, Xiuxian Chen, Yuhua Gu, Shuaijie Song, Fuliang Hu, Xu'’ai Lin, Simon Duttwyler, Hao Cheng, Stijn van der Veen.  (2025)  2-Hydroxychalcone is a gonococcal-specific antimicrobial with activity against elongation factor Tu and butanediol dehydrogenase.  LIFE SCIENCES,      [PMID:41015385] [10.1016/j.lfs.2025.123994]