Nuclear hormone receptors

Browse small molecules linked to nuclear hormone receptor targets for endocrine biology, transcription studies, and receptor screening. Use this page to compare modulators relevant to ligand-regulated signaling and mechanism-focused research.

Browse by type, application, or key specifications such as purity, grade, packaging, and handling requirements.

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Thyroid hormone receptor beta (THRB)

501

Explore Thyroid hormone receptor beta (THRB) →

Estrogen receptor (ESR1)

465

Explore Estrogen receptor (ESR1) →

Estrogen receptor beta (ESR2)

277

Explore Estrogen receptor beta (ESR2) →

Oxysterols receptor lxr-beta (NR1H2)

142

Explore Oxysterols receptor lxr-beta (NR1H2) →

Nuclear receptor subfamily 1 group i member 2 (NR1I2)

352

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Progesterone receptor (PGR)

378

Explore Progesterone receptor (PGR) →

Androgen receptor (AR)

315

Explore Androgen receptor (AR) →

Peroxisome proliferator-activated receptor gamma (PPARG)

322

Explore Peroxisome proliferator-activated receptor gamma (PPARG) →

Photoreceptor-specific nuclear receptor (NR2E3)

Explore Photoreceptor-specific nuclear receptor (NR2E3) →

Nuclear receptor subfamily 4 group a member 1 (NR4A1)

Explore Nuclear receptor subfamily 4 group a member 1 (NR4A1) →

Glucocorticoid receptor (NR3C1)

252

Explore Glucocorticoid receptor (NR3C1) →

Nuclear receptor subfamily 0 group b member 1 (NR0B1)

Explore Nuclear receptor subfamily 0 group b member 1 (NR0B1) →

Nuclear receptor ror-gamma (RORC)

106

Explore Nuclear receptor ror-gamma (RORC) →

Peroxisome proliferator-activated receptor alpha (PPARA)

215

Explore Peroxisome proliferator-activated receptor alpha (PPARA) →

Bile acid receptor (NR1H4)

127

Explore Bile acid receptor (NR1H4) →

Peroxisome proliferator-activated receptor delta (PPARD)

165

Explore Peroxisome proliferator-activated receptor delta (PPARD) →

Popular Products

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GW 590735, Peroxisome proliferator-activated receptor alpha agonist
CAS: 622402-22-6 Formula: C₂₃H₂₁F₃N₂O₄S Molecular Weight: 478.48

≥98%

In Stock Item #: G275270

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Technical Identifiers

IUPAC Name

2-methyl-2-[4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbonyl]amino]methyl]phenoxy]propanoic acid

SMILES

CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NCC3=CC=C(C=C3)OC(C)(C)C(=O)O

InChIKey
ILUPZUOBHCUBKB-UHFFFAOYSA-N

InChI

1S/C23H21F3N2O4S/c1-13-18(33-20(28-13)15-6-8-16(9-7-15)23(24,25)26)19(29)27-12-14-4-10-17(11-5-14)32-22(2,3)21(30)31/h4-11H,12H2,1-3H3,(H,27,29)(H,30,show more

Synonyms
HMS3650D07 | DB07215 | QKY617BBX5 | EX-A5892 | ILUPZUOBHCUBKB-UHFFFAOYSA-N | 2-methyl-2-{4-[({4-methyl-2-[4-(trifluor...
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Lofepramine, Inhibitor of NET;Inhibitor of SERT
CAS: 23047-25-8 EC Number: 245-396-8 Formula: C₂₆H₂₇ClN₂O Molecular Weight: 418.97

Moligand™ ? ≥97%

In Stock Item #: L287104

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IUPAC Name

1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone

SMILES

CN(CCCN1C2=CC=CC=C2CCC3=CC=CC=C31)CC(=O)C4=CC=C(C=C4)Cl

InChIKey
SAPNXPWPAUFAJU-UHFFFAOYSA-N

InChI

1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3

Synonyms
1-(4-chlorophenyl)-2-{[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]methylamino}ethanone | Gamanil | HMS3413F21...
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GSK 9027
CAS: 1229096-88-1 Formula: C₂₇H₁₉F₄N₃O₂S Molecular Weight: 525.52

≥98%(HPLC)

In Stock Item #: G288349

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IUPAC Name

N-[4-[1-(4-fluorophenyl)indazol-5-yl]-3-(trifluoromethyl)phenyl]-1-phenylmethanesulfonamide

SMILES

C1=CC=C(C=C1)CS(=O)(=O)NC2=CC(=C(C=C2)C3=CC4=C(C=C3)N(N=C4)C5=CC=C(C=C5)F)C(F)(F)F

InChIKey
DXBJGDVBQPEMOB-UHFFFAOYSA-N

InChI

1S/C27H19F4N3O2S/c28-21-7-10-23(11-8-21)34-26-13-6-19(14-20(26)16-32-34)24-12-9-22(15-25(24)27(29,30)31)33-37(35,36)17-18-4-2-1-3-5-18/h1-16,33H,17H2

Synonyms
N-[4-[1-(4-Fluorophenyl)-1H-indazol-5-yl-3-(trifluoromethyl)phenyl]benzenesulfonamide
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GW 1929 hydrochloride
CAS: 1217466-21-1 PubChem CID: 56972174 Formula: C₃₀H₂₉N₃O₄•HCl Molecular Weight: 532.03

≥98%(HPLC)

Out of Stock Item #: G286659

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Technical Identifiers

IUPAC Name

(2S)-2-(2-benzoylanilino)-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]propanoic acid;hydrochloride

SMILES

CN(CCOC1=CC=C(C=C1)CC(C(=O)O)NC2=CC=CC=C2C(=O)C3=CC=CC=C3)C4=CC=CC=N4.Cl

InChIKey
KXNKIKXTGRMLEY-YCBFMBTMSA-N

InChI

1S/C30H29N3O4.ClH/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23;/h2-18,27,32H,19-show more

Synonyms
N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrochloride
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PD 168077 maleate
CAS: 630117-19-0 Formula: C₂₀H₂₂N₄O.C₄H₄O₄ Molecular Weight: 450.49

≥97%

In Stock Item #: P286721

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Technical Identifiers

IUPAC Name

(Z)-but-2-enedioic acid;N-[[4-(2-cyanophenyl)piperazin-1-yl]methyl]-3-methylbenzamide

SMILES

CC1=CC(=CC=C1)C(=O)NCN2CCN(CC2)C3=CC=CC=C3C#N.C(=CC(=O)O)C(=O)O

InChIKey
NAEUGRPISCANHO-BTJKTKAUSA-N

InChI

1S/C20H22N4O.C4H4O4/c1-16-5-4-7-17(13-16)20(25)22-15-23-9-11-24(12-10-23)19-8-3-2-6-18(19)14-21;5-3(6)1-2-4(7)8/h2-8,13H,9-12,15H2,1H3,(H,22,25);1-2H,show more

Synonyms
N-((4-(2-Cyanophenyl)-1-piperazinyl)methyl)-3-methylbenzamide (2Z)-2-butenedioate (1:1) | HY-21098A | N-(Methyl-4-(2-...
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Retinoic acid
CAS: 302-79-4 EC Number: 206-129-0 Formula: C₂₀H₂₈O₂ Molecular Weight: 300.44

Moligand™ ? ≥98%

In Stock Item #: R106320

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Technical Identifiers

IUPAC Name

(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid

SMILES

CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C

InChIKey
SHGAZHPCJJPHSC-YCNIQYBTSA-N

InChI

1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+

Synonyms
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid | TRETINOIN COMPONENT OF...
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Retinol, Agonist of Testicular receptor 4
CAS: 68-26-8 EC Number: 200-683-7 Formula: C₂₀H₃₀O Molecular Weight: 286.45

Solid Moligand™ ? ≥95%

In Stock Item #: V111674

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IUPAC Name

(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol

SMILES

CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CCO)C)C

InChIKey
FPIPGXGPPPQFEQ-OVSJKPMPSA-N

InChI

1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+

Synonyms
Chocola A | Vitamin A (Natural) | Vitamin A1, all-trans- | Vitpex | 2,4,6,8-Nonatetraen-1-ol, 3,7-dimethyl-9-(2,6,6-t...
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Nimodipine, Gating inhibitor of Ca v1.1;Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Gating inhibitor of Ca v1.4;Activator of CFTR;Antagonist of Mineralocorticoid receptor;Allosteric modulator of P2X4
CAS: 66085-59-4 EC Number: 266-127-0 Formula: C₂₁H₂₆N₂O₇ Molecular Weight: 418.44

Solid Moligand™ ? ≥98%

In Stock Item #: N129506

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Technical Identifiers

IUPAC Name

3-O-(2-methoxyethyl) 5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

SMILES

CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC

InChIKey
UIAGMCDKSXEBJQ-UHFFFAOYSA-N

InChI

1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3

Synonyms
Nimodipine ap | SPECTRUM1503600 | 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-d...
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Rutaecarpine
CAS: 84-26-4 EC Number: 635-907-6 PubChem CID: 65752 Formula: C₁₈H₁₃N₃O Molecular Weight: 287.32

≥98%

In Stock Item #: R107338

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IUPAC Name

3,13,21-triazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-1(21),2(10),4,6,8,15,17,19-octaen-14-one

SMILES

C1CN2C(=NC3=CC=CC=C3C2=O)C4=C1C5=CC=CC=C5N4

InChIKey
ACVGWSKVRYFWRP-UHFFFAOYSA-N

InChI

1S/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H2

Synonyms
C18H13N3O | SMR001230721 | RUTECARPINE [MI] | Indolo[2',4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13-dihydro- | Rutaecar...
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NBI 27914 hydrochloride, Antagonist of CRF 1 receptor
CAS: 184241-44-9 EC Number: 634-053-1 Formula: C₁₈H₂₀Cl₄N₄ Molecular Weight: 434.19

Moligand™ ? ≥99%

Out of Stock Item #: N332118

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IUPAC Name

5-chloro-4-N-(cyclopropylmethyl)-2-methyl-4-N-propyl-6-N-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine

SMILES

CCCN(CC1CC1)C2=NC(=NC(=C2Cl)NC3=C(C=C(C=C3Cl)Cl)Cl)C

InChIKey
KNADXBVKFAUMCR-UHFFFAOYSA-N

InChI

1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)

Synonyms
CAS-29964-84-9 | NCGC00015737-04 | NCGC00015737-05 | NCGC00015737-08 | 4,6-Pyrimidinediamine, 5-chloro-N-(cyclopropyl...
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Mestranol, Estrogen receptor alpha agonist
CAS: 72-33-3 EC Number: 200-777-8 Formula: C₂₁H₂₆O₂ Molecular Weight: 310.43

Moligand™ ? ≥99%

In Stock Item #: M129878

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IUPAC Name

(8R,9S,13S,14S,17R)-17-ethynyl-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol

SMILES

CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)OC

InChIKey
IMSSROKUHAOUJS-MJCUULBUSA-N

InChI

1S/C21H26O2/c1-4-21(22)12-10-19-18-7-5-14-13-15(23-3)6-8-16(14)17(18)9-11-20(19,21)2/h1,6,8,13,17-19,22H,5,7,9-12H2,2-3H3/t17-,18-,19+,20+,21+/m1/s1

Synonyms
NSC 84032 | 17-alpha-Ethynyl-3-methoxy-1,3,5(10)-estratrien-17-beta-ol | MESTRANOL [WHO-DD] | AI3-51798 | Inostral | ...
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Bisphenol A, Antagonist of Androgen receptor;Agonist of Estrogen receptor-β
CAS: 80-05-7 EC Number: 201-245-8 Formula: C₁₅H₁₆O₂ Molecular Weight: 228.29

Solid Analytical standard ? Moligand™ ? for pharmaceutical anlysis

In Stock Item #: B108653

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Technical Identifiers

IUPAC Name

4-[2-(4-hydroxyphenyl)propan-2-yl]phenol

SMILES

CC(C)(C1=CC=C(C=C1)O)C2=CC=C(C=C2)O

InChIKey
IISBACLAFKSPIT-UHFFFAOYSA-N

InChI

1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3

Synonyms
Bis(4-hydroxyphenyl) dimethylmethane | bis-phenol-a | Bisphenol-A | DTXCID30182 | 4,2-propane | 4,4'-Dihydroxdiphenyl...

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This page brings together compounds associated with nuclear hormone receptor biology, a target class closely linked to transcriptional regulation and metabolic signaling. Researchers usually compare receptor subtype, agonist or antagonist profile, cofactor effects, cell-based activity, selectivity, and endocrine or metabolic context when browsing compounds. Nuclear receptor research often requires quick comparison across related ligand-activated transcription factors rather than a single target in isolation. This category helps users narrow from receptor family to specific biological questions and downstream assay work.