≥95%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Conserver à -20°C Ships Glacière + blocs de glace Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
description du produit :
Composé chloroacétyl-indole perméable aux cellules qui inhibe l'activité kinase d'Akt1 et d'Akt2 (IC50<1 µM) en ciblant directement le domaine PH d'Akt, présentant une activité faible ou très réduite contre un panel de 84 autres kinases, y compris la PI-3 Kinase (60 % d'inhibition à 10 µM). Inhibe efficacement la phosphorylation cellulaire GSK3β Ser9 et mTOR Ser2448 médiée par Akt (4 µM dans les cultures HCT116) de manière dépendante du temps, ce qui entraîne une induction efficace de l'apoptose dans les cultures HCT116 et HT29 (de 55 % et 60 %, respectivement ; 4 µM pendant 4 jours). Il a été rapporté que le produit retardait de 50 % la croissance des tumeurs dérivées de HCT116 lorsqu'il était administré à une dose orale de 30 mg/kg à des souris (5 fois/semaine pendant 3 semaines) in vivo.
| Pubchem Sid | 528759298 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/528759298 |
| Sourires canoniques | C1=CC=C2C(=C1)C(=CN2)C(=O)CCl |
| IUPAC Name | 2-chloro-1-(1H-indol-3-yl)ethanone |
| InChIKey | LLZQFAXTCYDVTR-UHFFFAOYSA-N |
| INCHI | 1S/C10H8ClNO/c11-5-10(13)8-6-12-9-4-2-1-3-7(8)9/h1-4,6,12H,5H2 |
| Isomères SMILES | C1=CC=C2C(=C1)C(=CN2)C(=O)CCl |
| WGK Allemagne | 3 |
| Poids moléculaire | 193.63 |
| Reaxy-Rn | 142045 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=142045&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Classe | Indoles and derivatives |
| Subclass | Indoles |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Indoles |
| Alternative Parents | Aryl alkyl ketones Substituted pyrroles Benzenoids Vinylogous amides Heteroaromatic compounds Alpha-chloroketones Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organochlorides Organic oxides Hydrocarbon derivatives Alkyl chlorides |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Indole - Aryl alkyl ketone - Aryl ketone - Substituted pyrrole - Benzenoid - Alpha-haloketone - Alpha-chloroketone - Pyrrole - Heteroaromatic compound - Vinylogous amide - Ketone - Azacycle - Alkyl chloride - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Organic oxygen compound - Organic nitrogen compound - Alkyl halide - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as indoles. These are compounds containing an indole moiety, which consists of pyrrole ring fused to benzene to form 2,3-benzopyrrole. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Article |
|---|---|---|---|
 G2403374 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403375 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403376 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403377 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403378 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403379 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403380 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403381 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403382 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403383 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403405 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403406 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403407 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403408 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| Solubilité | DMSO: 100 mg/mL |
|---|---|
| Sensibilité | light sensitive |
| Poids moléculaire | 193.630 g/mol |
| XLogP3 | 2.700 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 2 |
| Exact Mass | 193.029 Da |
| Monoisotopic Mass | 193.029 Da |
| Topological Polar Surface Area | 32.900 Ų |
| Heavy Atom Count | 13 |
| Formal Charge | 0 |
| Complexity | 207.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
