6-Hydroxydopamine hydrobromide - Moligand™,10mM in DMSO , CAS No.636-00-0

CAS: 636-00-0 Cat. No.: H425227 Formule: (HO)₃C₆H₂CH₂CH₂NH₂ · HBr Poids moléculaire: 250.09 Beilstein Registry Number: 3713280 Numéro CE: 211-247-0

QUALITÉ & PURETÉ Moligand™, 10mM in DMSO

Synonyms

2,5-Dihydroxytyramine hydrobromide | HY-B1081A | SY102034 | 6-OHDA hydrobromide6-Hydroxydopamine hydrobromide | 5-(2-aminoethyl)benzene-1,2,4-triol;hydrobromide | BCP25700 | NSC238469 | NSC-238469 | TWC1D4W0WB | EINECS 217-598-6 | 636-00-0 (HBr) | Q272904

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Solutions should be freshly prepared and protected from exposure to light.
6-Hydroxydopamine hydrobromide is a neurotoxin which destroys catecholaminergic terminals.

product description：

6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson's disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.

Spécifications

Synonymes

2,5-Dihydroxytyramine hydrobromide | HY-B1081A | SY102034 | 6-OHDA hydrobromide6-Hydroxydopamine hydrobromide | 5-(2-aminoethyl)benzene-1,2,4-triol;hydrobromide | BCP25700 | NSC238469 | NSC-238469 | TWC1D4W0WB | EINECS 217-598-6 | 636-00-0 (HBr) | Q272904

Spécifications et pureté

Moligand™,10mM in DMSO

Mécanismes biochimiques et physiologiques

Neurotoxin that destroys catecholaminergic terminals.Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels. Induces apoptosis in PC-12 cells.\xa0Destroys\xa0nigral dopaminergic neurons and their striatal terminals\xa0in rat models of

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Noms et identifiants

Pubchem Sid

528762568

Sourires canoniques

C1=C(C(=CC(=C1O)O)O)CCN.Br

IUPAC Name

5-(2-aminoethyl)benzene-1,2,4-triol;hydrobromide

InChIKey

MLACDGUOKDOLGC-UHFFFAOYSA-N

INCHI

1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H

Isomères SMILES

C1=C(C(=CC(=C1O)O)O)CCN.Br

WGK Allemagne

3

RTECS

DC4600000

Poids moléculaire

250.09

Beilstein

3713280

Reaxy-Rn

3713280

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3713280&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Phenols
      • Subclass Benzenediols
        • Level5 Catechols
          • Level6 Catecholamines and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Phenols
• Subclass: Benzenediols
• Intermediate Tree Nodes: Catechols
• Direct Parent: Catecholamines and derivatives
• Alternative Parents: Phenethylamines Hydroxyquinols and derivatives 2-arylethylamines Aralkylamines 1-hydroxy-2-unsubstituted benzenoids Polyols Organopnictogen compounds Monoalkylamines Hydrocarbon derivatives Hydrobromides
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Catecholamine - Hydroxyquinol derivative - Phenethylamine - 2-arylethylamine - 1-hydroxy-2-unsubstituted benzenoid - Aralkylamine - Monocyclic benzene moiety - Polyol - Primary amine - Amine - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrobromide - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as catecholamines and derivatives. These are compounds containing 4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] or a derivative thereof formed by substitution.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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G6PD Tchem Glucose-6-phosphate 1-dehydrogenase (778 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

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Mécanismes d'action

Propriétés chimiques et physiques

• Sensibilité: Light&Moisture sensitive
• Point de fusion (°C): 216-220°C
• Poids moléculaire: 250.090 g/mol
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 249 Da
• Monoisotopic Mass: 249 Da
• Topological Polar Surface Area: 86.700 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 142.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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