≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Conserver à -20°C Ships Glacière + blocs de glace Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
le 7BIO est un bis-indole 3′ substitué inhibiteur de kinases, qui fonctionne comme un inducteur de mort cellulaire nonapoptotique indépendant des caspases. Il est intéressant de noter que le 7BIO n'a pas inhibé l'activité des CDK et de la GSK-3, qui est la cible de nombreux autres bis-indoles inhibiteurs de kinases. En outre, la recherche suggère que les bis-indoles inhibiteurs de kinases, également connus sous le nom d'indirubines, n'inhibent pas les CDK et GSK-3 lorsqu'il y a des substitutions en position 7 par le biais d'une entrave stérique. D'autres études indiquent que le 7BIO peut réduire considérablement le potentiel transmembranaire mitochondrial. En outre, le 7BIO provoque la dilatation du réticulum endoplasmique et la destruction cytoplasmique aiguë de noyaux isolés dont l'ADN est totalement intact. le 7BIO est également un puissant inhibiteur de l'Aurora kinase B et C.
| Pubchem Sid | 504773302 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504773302 |
| Sourires canoniques | C1=CC=C2C(=C1)C(=C(N2)C3=C(NC4=C3C=CC=C4Br)O)N=O |
| IUPAC Name | 7-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol |
| InChIKey | HYMACPDEJIEMST-UHFFFAOYSA-N |
| INCHI | 1S/C16H10BrN3O2/c17-10-6-3-5-9-12(16(21)19-13(9)10)15-14(20-22)8-4-1-2-7-11(8)18-15/h1-7,18-19,21H |
| Isomères SMILES | C1=CC=C2C(=C1)C(=C(N2)C3=C(NC4=C3C=CC=C4Br)O)N=O |
| PubChem CID | 135423792 |
| Poids moléculaire | 356.17 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Classe | Indoles and derivatives |
| Subclass | Hydroxyindoles |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Hydroxyindoles |
| Alternative Parents | Indoles Substituted pyrroles Benzenoids Aryl bromides Heteroaromatic compounds C-nitroso compounds Azacyclic compounds Organooxygen compounds Organobromides Organic oxides Hydrocarbon derivatives Organic anions |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Hydroxyindole - Indole - Aryl bromide - Aryl halide - Benzenoid - Substituted pyrrole - Heteroaromatic compound - Pyrrole - Organic nitroso compound - C-nitroso compound - Azacycle - Organic nitrogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organobromide - Organohalogen compound - Hydrocarbon derivative - Organic oxide - Organic anion - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as hydroxyindoles. These are organic compounds containing an indole moiety that carries a hydroxyl group. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Article |
|---|---|---|---|
 I2222545 | Certificate of Analysis | Jul 10, 2025 | B338496 |
| I2222546 | Certificate of Analysis | Jul 10, 2025 | B338496 |
| I2222547 | Certificate of Analysis | Jul 10, 2025 | B338496 |
| I2222552 | Certificate of Analysis | Jul 10, 2025 | B338496 |
| I2222656 | Certificate of Analysis | Jul 10, 2025 | B338496 |
| I2222670 | Certificate of Analysis | Jul 10, 2025 | B338496 |
| L2405145 | Certificate of Analysis | Jun 21, 2022 | B338496 |
| Solubilité | Soluble in DMSO |
|---|---|
| Poids moléculaire | 356.170 g/mol |
| XLogP3 | 3.900 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 354.996 Da |
| Monoisotopic Mass | 354.996 Da |
| Topological Polar Surface Area | 81.200 Ų |
| Heavy Atom Count | 22 |
| Formal Charge | 0 |
| Complexity | 438.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
