A 889425 - ≥99% , CAS No.1072921-02-8

CAS: 1072921-02-8 Cat. No.: A275024 Molecular Weight: 425.42 PubChem CID: 76848882

GRADE & PURITY ≥99%

Synonyms

N-(3-Methylpyridin-2-yl)-1-[4-(trifluoromethylsulfonyl)phenyl]-3,6-dihydro-2H-pyridine-4-carboxamide

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Specifications

Synonyms

N-(3-Methylpyridin-2-yl)-1-[4-(trifluoromethylsulfonyl)phenyl]-3, 6-dihydro-2H-pyridine-4-carboxamide

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Potent, selective TRPV1 antagonist (IC 50 values are 335 and 34 nM for rat and human TRPV1 respectively). Inhibits mechanotransmission in inflamed skin. Shows antinociceptive effects in vivo. Orally active.

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CC1=C(N=CC=C1)NC(=O)C2=CCN(CC2)C3=CC=C(C=C3)S(=O)(=O)C(F)(F)F
• IUPAC Name: N-(3-methylpyridin-2-yl)-1-[4-(trifluoromethylsulfonyl)phenyl]-3,6-dihydro-2H-pyridine-4-carboxamide
• InChIKey: KACDTVMXDRFPPA-UHFFFAOYSA-N
• INCHI: 1S/C19H18F3N3O3S/c1-13-3-2-10-23-17(13)24-18(26)14-8-11-25(12-9-14)15-4-6-16(7-5-15)29(27,28)19(20,21)22/h2-8,10H,9,11-12H2,1H3,(H,23,24,26)
• Isomeric SMILES: CC1=C(N=CC=C1)NC(=O)C2=CCN(CC2)C3=CC=C(C=C3)S(=O)(=O)C(F)(F)F
• PubChem CID: 76848882
• Molecular Weight: 425.42

Chemical and Physical Properties

• Solubility: Soluble in DMSO to 100 mM