Aβ/tau aggregation-IN-1 - ≥95% , CAS No.2252162-81-3

CAS: 2252162-81-3 Cat. No.: A646131 Formule: C₂₅H₂₁IN₂O Poids moléculaire: 492.35

GRADE & PURITY ≥95%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Vue d’ensemble

Aβ/tau aggregation-IN-1 is a potent Aβ 1-42 β-sheets formation and tau aggregation inhibitor. The K D values of Aβ/tau aggregation-IN-1 with Aβ 1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier

In Vitro

Aβ/tau aggregation-IN-1 (1 μM; 24 hours; HEK-293 T cells) significantly declines the tau aggregation foci. Aβ/tau aggregation-IN-1 with N-methylation of the quinolone ring effectively inhibits Aβ 1-42 aggregation by 84.7%–99.5% and tau aggregation by 71.2%–101.8%. Aβ/tau aggregation-IN-1 inhibits self-induced Aβ 1-42 aggregation by inhibiting the formation of β-sheets. Aβ/tau aggregation-IN-1 shows certain binding abilities with Aβ 1-42 and tau. The K D value of Aβ/tau aggregation-IN-1 with Aβ 1-42 is 160 μM. The K D value of Aβ/tau aggregation-IN-1 with tau is 337 μM. Aβ/tau aggregation-IN-1 interacts with Aβ 1-42 and tau through noncovalent interactions. MCE has not independently confirmed the accuracy of these methods. They are for reference only. ImmunofluorescenceCell Line: HEK-293 T cells Concentration: 1 μM Incubation Time: 24 hours Result: Significantly declined the tau aggregation foci.

Form:Solid

IC50& Target:Kd: 160 μM (Aβ1-42),Kd: 337 μM (tau)

Specifications

Spécifications et pureté

≥95%

Mécanismes biochimiques et physiologiques

Aβ/tau aggregation-IN-1 is a potent Aβ 1-42 β-sheets formation and tau aggregation inhibitor. The K D values of Aβ/tau aggregation-IN-1 with Aβ 1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier

Conditions de stockage de stockage

Store at 2-8°C,Protected from light,Desiccated

Expédié en

Wet ice

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Pureté

≥95%

Noms et identifiants

• Poids moléculaire: 492.35

Propriétés chimiques et physiques

• Solubilité: DMSO : 33.33 mg/mL (67.70 mM; ultrasonic and warming and heat to 60°C)