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· · COA & SDS disponible pour chaque produit · Expédition le jour même sur les articles en stock Abemaciclib methanesulfonate - ≥98% , CAS No.1231930-82-7
Synonyms
2-Pyrimidinamine, N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-, methanesulfonate (1:1) | CCG-264735 | LY2835219 (methanesulfonate) | ABEMACICLIB MESILATE [WHO-DD] | LY2835219 Mesy
Shipped In
Ice chest + Ice pads
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Why this grade ≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 3 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Vue d’ensemble LY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively.
Specifications Synonymes
2-Pyrimidinamine, N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-, methanesulfonate (1:1) | CCG-264735 | LY2835219 (methanesulfonate) | ABEMACICLIB MESILATE [WHO-DD] | LY2835219 Mesy
Spécifications et pureté
≥98%
Mécanismes biochimiques et physiologiques
LY2835219 is an cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. CDK4/6 dual inhibitor LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting
Conditions de stockage de stockage
Store at -20°C
Expédié en
Ice chest + Ice pads
Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.
Noms et identifiants Pubchem Sid Url
https://pubchem.ncbi.nlm.nih.gov/substance/504772167
Sourires canoniques
CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O
IUPAC Name
N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine;methanesulfonic acid
InChIKey
NCJPFQPEVDHJAZ-UHFFFAOYSA-N
INCHI
1S/C27H32F2N8.CH4O3S/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26;1-5(2,3)4/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34);1H3,(H,2,3,4)
Isomères SMILES
CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Classe Benzimidazoles Subclass Not available Intermediate Tree Nodes Not available Direct Parent Benzimidazoles Alternative Parents Aminopyridines and derivatives Aminopyrimidines and derivatives Aralkylamines Halopyrimidines N-alkylpiperazines Aryl fluorides Benzenoids Imidolactams N-substituted imidazoles Heteroaromatic compounds Alkanesulfonic acids Sulfonyls Methanesulfonates Organosulfonic acids Trialkylamines Azacyclic compounds Hydrocarbon derivatives Organofluorides Organic oxides Molecular Framework Not available Substituents Benzimidazole - Aminopyridine - Aminopyrimidine - Halopyrimidine - N-alkylpiperazine - Aralkylamine - Aryl fluoride - Imidolactam - Benzenoid - N-substituted imidazole - 1,4-diazinane - Aryl halide - Piperazine - Pyridine - Pyrimidine - Imidazole - Methanesulfonate - Heteroaromatic compound - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Organosulfonic acid - Sulfonyl - Azole - Alkanesulfonic acid - Tertiary amine - Tertiary aliphatic amine - Azacycle - Organic oxygen compound - Amine - Organohalogen compound - Organic nitrogen compound - Organofluoride - Organonitrogen compound - Organosulfur compound - Hydrocarbon derivative - Organic oxide - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as benzimidazoles. These are organic compounds containing a benzene ring fused to an imidazole ring (five member ring containing a nitrogen atom, 4 carbon atoms, and two double bonds). External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Structure 3D Cibles associées (humaines) Cibles associées (non humaines) Mécanismes d'action Certificats (CoA, COO, BSE/TSE et tableau d'analyse) Propriétés chimiques et physiques Solubilité DMSO 83 mg/mL Water 100 mg/mL Ethanol 24 mg/mL Sensibilité Moisture sensitive Poids moléculaire 602.700 g/mol XLogP3 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 12 Rotatable Bond Count 7 Exact Mass 602.26 Da Monoisotopic Mass 602.26 Da Topological Polar Surface Area 138.000 Ų Heavy Atom Count 42 Formal Charge 0 Complexity 815.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 2
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