AGN 194078 - 10mM in DMSO , CAS No.321995-62-4

CAS: 321995-62-4 Cat. No.: A655183 Formule: C₂₂H₂₃F₂NO₄ Poids moléculaire: 403.42

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

AGN 194078 is a selective RARα agonist with a K d and EC 50 of 3 and 112 nM, respectively.

In Vitro

AGN 194078 is a selective RARα agonist and binds to RARα with very high affinity, having a K d value of 3 nM, while being unable to bind to RARβ and binding only very weakly (K d =5600 nM) to RARγ. Furthermore, AGN 194078 maintains full transcriptional activity through RARα, with an EC 50 value of 112 nM, but only activated\nRARβ and RARγ with about 10% efficacy at the highest dose (1000 nM) tested. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Kd: 4 nM (RARα), EC50: 140 nM (RARα)

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

AGN 194078 is a selective RARα agonist with a K d and EC 50 of 3 and 112 nM, respectively.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

AGONIST

Noms et identifiants

Poids moléculaire

403.42