AGN 194078 - 10mM in DMSO , CAS No.321995-62-4

CAS: 321995-62-4 Cat. No.: A655183 Molecular Weight: 403.42

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

AGN 194078 is a selective RARα agonist with a K d and EC 50 of 3 and 112 nM, respectively.

In Vitro

AGN 194078 is a selective RARα agonist and binds to RARα with very high affinity, having a K d value of 3 nM, while being unable to bind to RARβ and binding only very weakly (K d =5600 nM) to RARγ. Furthermore, AGN 194078 maintains full transcriptional activity through RARα, with an EC 50 value of 112 nM, but only activated\nRARβ and RARγ with about 10% efficacy at the highest dose (1000 nM) tested. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Kd: 4 nM (RARα), EC50: 140 nM (RARα)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

AGN 194078 is a selective RARα agonist with a K d and EC 50 of 3 and 112 nM, respectively.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Names and Identifiers

• Molecular Weight: 403.42