AM630 - Moligand™, ≥97% , Antagonist of CB 2 receptor, CAS No.164178-33-0, Antagonist of CB 2 receptor

CAS: 164178-33-0 Cat. No.: A124994 Formule: C₂₃H₂₅IN₂O₃ Poids moléculaire: 504.36 Numéro CE: 803-134-5

GRADE & PURITY Moligand™, ≥97%

Synonyms

{6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl}[4-(methyloxy)phenyl]methanone | HMS3412K03 | U1LNJ6NBKA | 1-[2-(morpholin-4-yl)ethyl]-2-methyl-3-(4-methoxybenzoyl)-6-iodoindole | AKOS015998968 | AM630 | AM-630 | JHOTYHDSLIUKCJ-UHFFFAOYSA-N | SC

Storage

Store at 2-8°C

Shipped In

Wet ice

Vue d’ensemble

AM-630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors with Ki values of 5.2 μM and 31.2 nM, respectively. AM630 has been shown to display 165-fold selectivity over CB1 receptors and behave as a weak partial/inverse agonist at CB1 receptors. AM-630 acts as an inverse agonist on cloned human CB1 receptors.
A selective CB2 receptor antagonist that binds to CB1 and CB2 receptors

Specifications

Synonymes

{6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl}[4-(methyloxy)phenyl]methanone | HMS3412K03 | U1LNJ6NBKA | 1-[2-(morpholin-4-yl)ethyl]-2-methyl-3-(4-methoxybenzoyl)-6-iodoindole | AKOS015998968 | AM630 | AM-630 | JHOTYHDSLIUKCJ-UHFFFAOYSA-N | SC

Spécifications et pureté

Moligand™, ≥97%

Mécanismes biochimiques et physiologiques

AM630 est un antagoniste CB2 sélectif avec un Ki de 31,2 nM ; > 150 fois la sélectivité par rapport au récepteur CB1. AM630 est un antagoniste sélectif du récepteur CB2 qui se lie aux récepteurs CB1 et CB2 avec des valeurs Ki de 5,2 uM et 31,2 nM, respect

Conditions de stockage de stockage

Store at 2-8°C

Expédié en

Wet ice

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

ANTAGONIST

Mécanisme d'action

Antagonist of CB 2 receptor

Pureté

≥97%

Noms et identifiants

• Pubchem Sid: 508810309
• Sourires canoniques: CC1=C(C2=C(N1CCN3CCOCC3)C=C(C=C2)I)C(=O)C4=CC=C(C=C4)OC
• IUPAC Name: [6-iodo-2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]-(4-methoxyphenyl)methanone
• InChIKey: JHOTYHDSLIUKCJ-UHFFFAOYSA-N
• INCHI: 1S/C23H25IN2O3/c1-16-22(23(27)17-3-6-19(28-2)7-4-17)20-8-5-18(24)15-21(20)26(16)10-9-25-11-13-29-14-12-25/h3-8,15H,9-14H2,1-2H3
• Isomères SMILES: CC1=C(C2=C(N1CCN3CCOCC3)C=C(C=C2)I)C(=O)C4=CC=C(C=C4)OC
• WGK Allemagne: 3
• CAS alternatif: 164178-33-0
• Termes d'entrée MeSH: 1-(2-(morpholin-4-yl)ethyl)-2-methyl-3-(4-methoxybenzoyl)-6-iodoindole;2-methyl-3-(4-methoxybenzoyl)-6-iodo-1-(2-morpholinoethyl)-1H-indole;6-iodopravadoline;AM 630;AM-630;AM630;iodopravadoline;methanone, (6-iodo-2-methyl-1-(2-(4-morpholinyl)ethyl)-1H-ind
• Poids moléculaire: 504.36
• Reaxy-Rn: 8360417
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8360417&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Indoles and derivatives
      • Subclass Benzoylindoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Indoles and derivatives
• Subclass: Benzoylindoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzoylindoles
• Alternative Parents: Aryl-phenylketones Indolecarboxylic acids and derivatives N-alkylindoles Indoles Anisoles Benzoyl derivatives Methoxybenzenes Phenoxy compounds Alkyl aryl ethers Morpholines Aryl iodides Substituted pyrroles Vinylogous amides Heteroaromatic compounds Trialkylamines Dialkyl ethers Azacyclic compounds Oxacyclic compounds Hydrocarbon derivatives Organic oxides Organoiodides Organopnictogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzoylindole - Aryl-phenylketone - Indolecarboxylic acid derivative - N-alkylindole - Indole - Phenol ether - Aryl ketone - Phenoxy compound - Methoxybenzene - Anisole - Benzoyl - Alkyl aryl ether - Oxazinane - Benzenoid - Substituted pyrrole - Morpholine - Monocyclic benzene moiety - Aryl halide - Aryl iodide - Heteroaromatic compound - Vinylogous amide - Pyrrole - Tertiary aliphatic amine - Tertiary amine - Ketone - Oxacycle - Azacycle - Dialkyl ether - Ether - Organic oxygen compound - Amine - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organoiodide - Organohalogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as benzoylindoles. These are organic compounds containing an indole attached to a benzoyl moiety through the acyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Soluble in DMSO, DMF, ethanol, water (0.2 mg/ml) at 25 °C, and 1:4 DMF:PBS(pH 7.2) (0.2 mg/ml).
• Indice de réfraction: 1.65
• Point d'ébullition (°C): 605.93 °C at 760 mmHg
• Poids moléculaire: 504.400 g/mol
• XLogP3: 4.000
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 504.091 Da
• Monoisotopic Mass: 504.091 Da
• Topological Polar Surface Area: 43.700 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 548.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Références

1. Shiying Lin, Xin Liu, Jian Jiang, Wenqiang Ge, Qingxiao Tao, Suwen Liu, Ouyang Zhanmu, Yang Yang, Man Li, Hongxiang Chen.  (2026)  MAGL Inhibition Relieves Psoriasiform Inflammation and Pruritus Via Modulation of ALOX12-12-HETE Axis in Mice.  INFLAMMATION,  49  (1): (92).  [PMID:41774275] [10.1007/s10753-025-02383-5]