AMN082 free base - ≥98% , CAS No.83027-13-8

CAS: 83027-13-8 Cat. No.: A336629 Formule: C₂₈H₂₈N₂ Poids moléculaire: 392.54 PubChem CID: 11698390

QUALITÉ & PURETÉ ≥98%

Synonyms

N,N'-dibenzhydryl-1,2-ethanediamine dihydrochloride|N,N/'-dibenzhydrylethane-1,2-diamine;dihydrochloride|N,N'-dibenzhydrylethylenediamine dihydrochloride|AMN 082|N,N inverted exclamation marka-bis(diphenylmethyl)-1,2-ethanediamine, dihydrochloride|N,N'-bis(diphenylmethyl)ethane-1,2-diamine dihydrochloride|AMN082 2HCl|C28H28N2.2HCl|N,N'-Dibenzhydrylethane-1,2-diamine dihydrochloride|N,N'-dibenzhydrylethane-1,2-diamine;dihydrochloride|AMN082|AMN 082 (Free base)|N,N'-bis(diphenylmethyl)ethane-1,2-bis(aminium) dichloride|N1,N2-Dibenzhydrylethane-1,2-diamine dihydrochloride|AMN082 DIHYDROCHLORIDE|4-nitrophenyl-hydrazine|AMN 082 dihydrochloride|N(1),N(2)-bis(diphenylmethyl)ethane-1,2-bis(aminium) dichloride

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Vue d’ensemble

AMN082 Dihydrochloride is a potent and selective agonist at mGluR-7, acting at an allosteric site. mGluR-7 is a metabotropic glutamate receptor 7. AMN082 has been shown to promote the proliferation and differentiation of neural progenitor cells.

Product description：

AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects

Spécifications

Synonymes

N,N'-dibenzhydryl-1,2-ethanediamine dihydrochloride | N,N/'-dibenzhydrylethane-1,2-diamine;dihydrochloride | N,N'-dibenzhydrylethylenediamine dihydrochloride | AMN 082 | N,N inverted exclamation marka-bis(diphenylmethyl)-1,2-ethanediamine, dihydrochloride | N,N'-bis(diphenylmethyl)ethane-1,2-diamine dihydrochloride | AMN082 2HCl | C28H28N Afficher plus

Spécifications et pureté

≥98%

Conditions de stockage de stockage

Store at 2-8°C,Protected from light,Desiccated

Expédié en

Wet ice

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

AGONIST

Pureté

≥98%

Propriétés du produit

pKa

pKₐ: 8.38

Noms et identifiants

Pubchem Sid

508810310

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/508810310

Sourires canoniques

C1=CC=C(C=C1)C(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl

IUPAC Name

N,N'-dibenzhydrylethane-1,2-diamine;dihydrochloride

InChIKey

YRQCDCNQANSUPB-UHFFFAOYSA-N

INCHI

1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H

Isomères SMILES

C1=CC=C(C=C1)C(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl

WGK Allemagne

3

PubChem CID

11698390

Poids moléculaire

392.54

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Diphenylmethanes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Diphenylmethanes
• Intermediate Tree Nodes: Not available
• Direct Parent: Diphenylmethanes
• Alternative Parents: Aralkylamines Dialkylamines Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Diphenylmethane - Aralkylamine - Secondary amine - Secondary aliphatic amine - Organic nitrogen compound - Hydrocarbon derivative - Hydrochloride - Organonitrogen compound - Amine - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Soluble in DMSO (10 mg/ml), 100% ethanol, methanol (10 mM), and water.
• Sensibilité: light sensitive
• Point d'ébullition (°C): 533.7° C at 760 mmHg (Predicted)
• Poids moléculaire: 465.500 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 9
• Exact Mass: 464.179 Da
• Monoisotopic Mass: 464.179 Da
• Topological Polar Surface Area: 24.100 Ų
• Heavy Atom Count: 32
• Formal Charge: 0
• Complexity: 362.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3