10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 22 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Amphotericin B (AMB, NSC 527017) is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes.
In vitro
Amphotericin B administration is limited by infusion-related toxicity, including fever and chills, an effect postulated to result from proinflammatory cytokine production by innate immune cells. Amphotericin B induces signal transduction and inflammatory cytokine release from cells expressing TLR2 and CD14. Amphotericin B interacts with cholesterol, the major sterol of mammal membranes, thus limiting the usefulness of Amphotericin B due to its relatively high toxicity. Amphotericin B is dispersed as a pre-micellar or as a highly aggregated state in the subphase. Amphotericin B only kills unicellular Leishmania promastigotes (LPs) when aqueous pores permeable to small cations and anions are formed. Amphotericin B (0.1 mM) induces a polarization potential, indicating K+ leakage in KCl-loaded liposomes suspended in an iso-osmotic sucrose solution. Amphotericin B (0.05 mM) exhibits a nearly total collapse of the negative membrane potential, indicating Na+ entry into the cells.
In vivo
Amphotericin B results in prolonging the incubation time and decreasing PrPSc accumulation in the hamster scrapie model. Amphotericin B markedly reduces PrPSc levels in mice with transmissible subacute spongiform encephalopathies (TSSE). Amphotericin B exerts a direct effect on Plasmodium falciparum and influences eryptosis of infected erythrocytes, parasitemia and hostsurvival in murine malaria. Amphotericin B tends to delay the increase of parasitemia and significantly delays host death plasmodium berghei-infected mice.
Cell Data
cell lines：MDA-MB-231 cells
Concentrations：
Incubation Time：
Powder Purity:
| Isomeric SMILES | C[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O |
|---|---|
| Alternate CAS | 1202017-46-6 |
| Molecular Weight | 924.08 |
| Beilstein | 78342 |
| Reaxy-Rn | 31131291 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31131291&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Melt Point(°C) | >170°C |
|---|
| 1. Ting Fang, Juan Xiong, Li Wang, Zhe Feng, Sijin Hang, Jinhua Yu, Wanqian Li, Yanru Feng, Hui Lu, Yuanying Jiang. (2023) Unexpected Inhibitory Effect of Octenidine Dihydrochloride on Candida albicans Filamentation by Impairing Ergosterol Biosynthesis and Disrupting Cell Membrane Integrity. Antibiotics-Basel, 12 (12): (1675). [PMID:38136708] [10.3390/antibiotics12121675] |
| 2. Haifeng Lu, Qi Lu, Hongwu Sun, Zhongkun Wang, Xiang Shi, Yuling Ding, Xiang Ran, Jing Pei, Yubo Pan, Qunlin Zhang. (2023) ROS-Responsive Fluorescent Sensor Array for Precise Diagnosis of Cancer via pH-Controlled Multicolor Gold Nanoclusters. ACS Applied Materials & Interfaces, [PMID:37531495] [10.1021/acsami.3c09320] |
| 3. Mingzhu Zhu, Chen He, Jinchuan Zhou, Yi Li, Lilin Qian, Jiaozhen Zhang, Yanan Qiao, Wenqiang Chang, Hongxiang Lou. (2023) Liverwort-Derived Metabolites Retard Endophyte Growth and Inspire Antifungal Application. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:36919252] [10.1021/acs.jafc.2c08866] |
| 4. Hui Lu, Wanqian Li, Malcolm Whiteway, Hongkang Wang, Shuo Zhu, Zhe Ji, Yanru Feng, Lan Yan, Ting Fang, Liping Li, Tingjunhong Ni, Xiaolong Zhang, Quanzhen Lv, Zichao Ding, Lijuan Qiu, Dazhi Zhang, Yuanying Jiang. (2022) A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols. mBio, 14 (1): [PMID:36475771] [10.1128/mbio.02639-22] |
| 5. Guo Penghao, Chen Jianlong, Tan Yiwei, Xia Li, Zhang Weizheng, Li Xiaojie, Jiang Yujie, Li Ruiying, Chen Chunmei, Liao Kang, Peng Yaqin. (2022) Comparison of molecular and MALDI-TOF MS identification and antifungal susceptibility of clinical Fusarium isolates in Southern China. Frontiers in Microbiology, [PMID:36386677] [10.3389/fmicb.2022.992582] |
| 6. Xinhua Liu, Youteng Qin, Liyun Dong, Ziyi Han, Tianning Liu, Ying Tang, Yun Yu, Jingjie Ye, Juan Tao, Xuan Zeng, Jun Feng, Xian-Zheng Zhang. (2022) Living symbiotic bacteria-involved skin dressing to combat indigenous pathogens for microbiome-based biotherapy toward atopic dermatitis. Bioactive Materials, [PMID:36157249] [10.1016/j.bioactmat.2022.08.019] |
| 7. Xin Yang, Zejun Pei, Renjing Hu, Zhehao Zhang, Zaixiang Lou, Xin Sun. (2021) Study on the Inhibitory Activity and Possible Mechanism of Myriocin on Clinically Relevant Drug-Resistant Candida albicans and Its Biofilms. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 44 (3): (305-315). [PMID:33441497] [10.1248/bpb.b20-00246] |
| 8. Xiaowen He, Lantong Zhang, Jinping Chen, Jinlei Sui, Guohui Yi, Jinyan Wu, Yinzheng Ma. (2019) Correlation between Chemical Composition and Antifungal Activity of Clausena lansium Essential Oil against Candida spp.. MOLECULES, 24 (7): (1394). [PMID:30970599] [10.3390/molecules24071394] |
| 9. Chen Xing, Chunqing Qin, Xueqing Li, Fuming Zhang, Robert J. Linhardt, Peilong Sun, Anqiang Zhang. (2019) Chemical composition and biological activities of essential oil isolated by HS-SPME and UAHD from fruits of bergamot. LWT-FOOD SCIENCE AND TECHNOLOGY, [PMID:] [10.1016/j.lwt.2019.01.020] |
| 10. Lu Wang, Yanan Wu, Tao Huang, Kan Shi, Zhenqiang Wu. (2017) Chemical Compositions, Antioxidant and Antimicrobial Activities of Essential Oils of Psidium guajava L. Leaves from Different Geographic Regions in China. CHEMISTRY & BIODIVERSITY, 14 (9): (e1700114). [PMID:28618209] [10.1002/cbdv.201700114] |
| 11. Wang Aoke, Ahmad Aftab, Ullah Sadeeq, Cheng Li, Ke Lin, Yuan Qipeng. (2017) A Cheap and Convenient Method of Liposome Preparation Using Glass Beads as a Source of Shear Force. AAPS PHARMSCITECH, 18 (8): (3227-3235). [PMID:28560505] [10.1208/s12249-017-0812-3] |
| 12. Tan-Jun Wang, Yi-Ming Shan, Han Li, Wei-Wang Dou, Xin-Hang Jiang, Xu-Ming Mao, Shui-Ping Liu, Wen-Jun Guan, Yong-Quan Li. (2016) Multiple transporters are involved in natamycin efflux in Streptomyces chattanoogensis L10. MOLECULAR MICROBIOLOGY, 103 (4): (713-728). [PMID:27874224] [10.1111/mmi.13583] |
| 13. Gao Mei-yue, Qi Huan, Li Jian-song, Zhang Hui, Zhang Ji, Wang Ji-dong, Xiang Wen-sheng. (2016) A new polysubstituted cyclopentene derivative from Streptomyces sp. HS-NF-1046. JOURNAL OF ANTIBIOTICS, 70 (2): (216-218). [PMID:27599764] [10.1038/ja.2016.111] |
| 14. Li Wanqian, Whiteway Malcolm, Hang Sijin, Yu Jinhua, Lu Hui, Jiang Yuanying. (2025) Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles’ antifungal activities. Nature Communications, 16 (1): (1-18). [PMID:40707518] [10.1038/s41467-025-62131-z] |
| 15. Yu Xiang-Fang, Gurung Chetali, Yu Zhongjia, Xiao Wei, Kerem Goher, Teng Bin, Zhang Jian V., Su Zhe, Zhou Yongjin, Ren Pei-Gen. (2025) Intestinal bacteria translocation promotes β-cell dysfunction in DIO mice. Scientific Reports, 15 (1): (1-11). [PMID:40849329] [10.1038/s41598-025-15244-w] |
| 16. Zhongjia Yu, Xiang-Fang Yu, Goher Kerem, Pei-Gen Ren. (2022) Perturbation on gut microbiota impedes the onset of obesity in high fat diet-induced mice. Frontiers in Endocrinology, [PMID:36017311] [10.3389/fendo.2022.795371] |
| 17. Yang Yang, Yuanji Zhao, Huan Lei, Xiaohong Tan. (2024) Limosilactobacillus Fermentun ZS09 Can Improve Antibiotic-Induced Motor Dysfunction in Mice by Regulating the Brain–Gut Functions. Journal of Inflammation Research, [PMID:39634287] [10.2147/JIR.S486018] |
| 18. Cheng Zhen, Li Wang, Yanru Feng, Malcolm Whiteway, Sijin Hang, Jinhua Yu, Hui Lu, Yuanying Jiang. (2024) Otilonium Bromide Exhibits Potent Antifungal Effects by Blocking Ergosterol Plasma Membrane Localization and Triggering Cytotoxic Autophagy in Candida Albicans. Advanced Science, [PMID:38995235] [10.1002/advs.202406473] |
| 19. Zhang Jiayu, Yang Jinneng, Luo Jinyan, Wu Weili, Luo Haidan, Wei Wenxia, Lyu Haimei, Wang Yuzhi, Yi Hairong, Zhang Yijing, Fan Zongmin, Lyu Haiwen, Kanakaveti Vishnu Priya, Qin Baifu, Yuan Ping, Yang Runxiang, Zhang Haipeng, Zuo Tao, Felsher Dean W., Lee Mong-Hong, Li Kai. (2025) Lactobacillus acidophilus potentiates oncolytic virotherapy through modulating gut microbiota homeostasis in hepatocellular carcinoma. Nature Communications, 16 (1): (1-20). [PMID:40195307] [10.1038/s41467-025-58407-z] |
| 20. Xiao-li Liu, Si-yi Wu, Zhan-peng Zou, Xiting Xian, Jingyuan Wang, Li Min, Yuanyuan Zhou, Kurt Houf, Zhongjia Yu. (2025) Characterization and intestinal pathogenicity of Proteus mirabilis isolated from broiler carcasses and processing environments. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, [PMID:41101217] [10.1016/j.ijfoodmicro.2025.111487] |
| 21. Xinda You, Zifan Song, Youqing Tian, Ran Chen, Yuxiang Wu, Meijie Wang, Dai Shi, Shan Luo, Jiamei Sun, Yuanhui Xiao, Haixiong Liu, Hanyang Liu, Beili Lu, Lirong Tang, Xingzhong Cao, Jiande Lin, Biao Huang. (2025) Coordination-reconstructed cellulose membranes for precise molecular separation. JOURNAL OF MEMBRANE SCIENCE, [PMID:] [10.1016/j.memsci.2025.125020] |
| 22. Xiaoyun Liu, Qiuyue Diao, Mingliang Li, Yuting Yang, Jiayin Liang, Zehua Cui, Haiyan Zhang, Huiling He, Jiabao Huang, Hao Ren, Fengli Zhou, Tijiang Shan, Xiaopin Liao, Jian Sun, Kouxing Zhang. (2025) Worldwide distribution of human pythosis and biological characteristics of a Pythium insidiosum strain susceptible to antibiotics from China: a dual-scale study. Frontiers in Medicine, [PMID:41446846] [10.3389/fmed.2025.1629018] |
