Angiotensin Ⅱ, human - Moligand™, ≥90% , CAS No.4474-91-3

CAS: 4474-91-3 Cat. No.: A107852 Molecular Weight: 1046.18

GRADE & PURITY Moligand™, ≥90%

Synonyms

CHEBI:131170 | CHEBI:48432 | HB3488 | ty-10721 | Angiotensin II, ile(5)- | Q27293293 | 5-L-Isoleucineangiotensin II | Angiotensin II (acetate);Ang II (acetate);DRVYIHPF (acetate) | C50H71N13O12 | Angiotensinum II | Angiotensin 2 | Angiotensin II (human ty

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Sequence: H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
General description
Research area: Cell signaling
Cell permeable: no
Primary Target adenylate cyclase activity
Product does not compete with ATP.
Reversible: no

Specifications

Synonyms

CHEBI:131170 | CHEBI:48432 | HB3488 | ty-10721 | Angiotensin II, ile(5)- | Q27293293 | 5-L-Isoleucineangiotensin II | Angiotensin II (acetate);Ang II (acetate);DRVYIHPF (acetate) | C50H71N13O12 | Angiotensinum II | Angiotensin 2 | Angiotensin II (human ty

Specifications & Purity

Moligand™, ≥90%

Biochemical and Physiological Mechanisms

Angiotensin II is a crucial component of the Renin-Angiotensin System (RAS). It plays a vital role in vasoconstriction, regulating blood pressure, and controlling fluid balance by influencing the retention of sodium and water in the renal tubules. Further

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Purity

≥90%

Names and Identifiers

• Pubchem Sid: 504757667
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504757667
• Canonical Smiles: CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
• IUPAC Name: (3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
• InChIKey: CZGUSIXMZVURDU-JZXHSEFVSA-N
• INCHI: 1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1
• Isomeric SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N
• WGK Germany: 3
• RTECS: BW2165000
• Molecular Weight: 1046.18
• Reaxy-Rn: 25124120
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25124120&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Oligopeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Oligopeptides
• Alternative Parents: Tyrosine and derivatives Phenylalanine and derivatives Histidine and derivatives Aspartic acid and derivatives Isoleucine and derivatives Valine and derivatives Proline and derivatives N-acyl-L-alpha-amino acids Alpha amino acid amides Phenylpropanoic acids Amphetamines and derivatives Imidazolyl carboxylic acids and derivatives Pyrrolidinecarboxamides N-acylpyrrolidines 1-hydroxy-2-unsubstituted benzenoids Dicarboxylic acids and derivatives N-acyl amines Tertiary carboxylic acid amides Heteroaromatic compounds Amino acids Secondary carboxylic acid amides Guanidines Azacyclic compounds Propargyl-type 1,3-dipolar organic compounds Carboxylic acids Carboximidamides Carbonyl compounds Hydrocarbon derivatives Monoalkylamines Organic oxides Organopnictogen compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Alpha-oligopeptide - Tyrosine or derivatives - Phenylalanine or derivatives - Histidine or derivatives - Aspartic acid or derivatives - Isoleucine or derivatives - N-acyl-alpha-amino acid - N-acyl-alpha amino acid or derivatives - N-acyl-l-alpha-amino acid - Valine or derivatives - Proline or derivatives - Alpha-amino acid amide - 3-phenylpropanoic-acid - Alpha-amino acid or derivatives - N-substituted-alpha-amino acid - Amphetamine or derivatives - N-acylpyrrolidine - Pyrrolidine-2-carboxamide - Imidazolyl carboxylic acid derivative - Pyrrolidine carboxylic acid or derivatives - Phenol - 1-hydroxy-2-unsubstituted benzenoid - Monocyclic benzene moiety - Dicarboxylic acid or derivatives - Fatty acyl - Fatty amide - Benzenoid - N-acyl-amine - Pyrrolidine - Tertiary carboxylic acid amide - Imidazole - Heteroaromatic compound - Azole - Amino acid or derivatives - Amino acid - Carboxamide group - Guanidine - Secondary carboxylic acid amide - Carboximidamide - Carboxylic acid - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organooxygen compound - Organopnictogen compound - Carbonyl group - Hydrocarbon derivative - Organic oxygen compound - Primary amine - Organic nitrogen compound - Amine - Organonitrogen compound - Organic oxide - Primary aliphatic amine - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
• External Descriptors: Angiotensin [KO:K09821]

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

AGTR1 Tclin Type-1 angiotensin II receptor (0 Activities)

Discover Target: AGTR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AGTR2 Tchem Type-2 angiotensin II receptor (0 Activities)

Discover Target: AGTR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK3 Tclin Potassium channel subfamily K member 3 (0 Activities)

Discover Target: KCNK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)

Discover Target: ADRB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)

Discover Target: AGTR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRD1 Tclin Delta opioid receptor (15096 Activities)

Discover Target: OPRD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)

Discover Target: GBA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PC-3 (62116 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NCI-H295R (47 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)

Discover Target: Agtr2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Agtr1b Type-1B angiotensin II receptor (525 Activities)

Discover Target: Agtr1b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AGTR1 Angiotensin II type 1a (AT-1a) receptor (440 Activities)

Discover Target: AGTR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Agtr1 Type-1A angiotensin II receptor (520 Activities)

Discover Target: Agtr1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Oryctolagus cuniculus (11301 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GCN5 Histone acetyltransferase GCN5 (89 Activities)

Discover Target: GCN5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Agtr1b Angiotensin II receptor (1735 Activities)

Discover Target: Agtr1b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Agtr1b Angiotensin II receptor (AT-1) type-1 (1480 Activities)

Discover Target: Agtr1b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: insoluble in DMSO; insoluble in EtOH
• Sensitivity: Heat Sensitive
• Molecular Weight: 1046.200 g/mol
• XLogP3: -1.700
• Hydrogen Bond Donor Count: 13
• Hydrogen Bond Acceptor Count: 15
• Rotatable Bond Count: 29
• Exact Mass: 1045.53 Da
• Monoisotopic Mass: 1045.53 Da
• Topological Polar Surface Area: 409.000 Ų
• Heavy Atom Count: 75
• Formal Charge: 0
• Complexity: 1980.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 9
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Wang Meng-yang, Yu Tian-xiang, Wang Qin-yan, Han Xue, Hu Xiang, Ye Shi-ju, Long Xiao-hong, Wang Yi, Zhu Hong, Luo Wu, Liang Guang.  (2023)  OTUD1 promotes hypertensive kidney fibrosis and injury by deubiquitinating CDK9 in renal epithelial cells.  ACTA PHARMACOLOGICA SINICA,      [PMID:38110583] [10.1038/s41401-023-01192-6]

2. Jiajia Zhang, Yu Tu, Jiajia Wei, Ruyi Zheng, Ji Shao, Qinhua Chen, Guang Liang, Huazhong Ying, Xue Han, Qiaojuan Shi.  (2023)  Dectin1 contributes to hypertensive vascular injury by promoting macrophage infiltration through activating the Syk/NF-κB pathway.  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,      [PMID:37813169] [10.1016/j.bbadis.2023.166911]

3. Yushu Liu, Dong Wang, Yimin Jin, Guifang Sun, Qi Lou, Hong Wang, Weimin Li.  (2023)  Costunolide ameliorates angiotensin II-induced atrial inflammation and fibrosis by regulating mitochondrial function and oxidative stress in mice: A possible therapeutic approach for atrial fibrillation.  MICROVASCULAR RESEARCH,      [PMID:37666318] [10.1016/j.mvr.2023.104600]

4. Wang Shuai, Bai Jie, Che Yilin, Qu Weikun, Li Jing.  (2023)  Fucoidan inhibits apoptosis and improves cardiac remodeling by inhibiting p53 transcriptional activation through USP22/Sirt 1.  Frontiers in Pharmacology,      [PMID:37324479] [10.3389/fphar.2023.1164333]

5. Fangze Huang, Ximao Liu, Junjie Liu, Yu Xie, Li Zhao, Deshen Liu, Zifeng Zeng, Xiu Liu, Shaoyi Zheng, Zezhou Xiao.  (2023)  Phosphatidylethanolamine aggravates Angiotensin II-induced atrial fibrosis by triggering ferroptosis in mice.  Frontiers in Pharmacology,      [PMID:37288112] [10.3389/fphar.2023.1148410]

6. Mengyang Wang, Xue Han, Tianxiang Yu, Minxiu Wang, Wu Luo, Chunpeng Zou, Xiuyun Li, Gao Li, Gaojun Wu, Yi Wang, Guang Liang.  (2023)  OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes.  Theranostics,      [PMID:37153745] [10.7150/thno.83340]

7. Tian-Lun Wen, Jia-Hui Bai, Ming-Mai Bao, Yong Qin, Yue Su, Yin-Long Guo.  (2023)  Ultrasonic sample introduction combined with flame assisted thermal ionization: Pretreatment-free direct mass spectrometry analysis for fraction collecting tubes of preparative liquid chromatography.  TALANTA,      [PMID:37043878] [10.1016/j.talanta.2023.124508]

8. Weiwei Zhu, Minxiu Wang, Leiming Jin, Bin Yang, Bin Bai, Rumbidzai Natasha Mutsinze, Wei Zuo, Nipon Chattipakorn, Joo Young Huh, Guang Liang, Yi Wang.  (2022)  Licochalcone A protects against LPS-induced inflammation and acute lung injury by directly binding with myeloid differentiation factor 2 (MD2).  BRITISH JOURNAL OF PHARMACOLOGY,  180  (8): (1114-1131).  [PMID:36480410] [10.1111/bph.15999]

9. Siyuan Shen, Gaojun Wu, Wu Luo, Weixin Li, Xiaobo Li, Chengyi Dai, Weijian Huang, Guang Liang.  (2022)  Leonurine attenuates angiotensin II-induced cardiac injury and dysfunction via inhibiting MAPK and NF-κB pathway.  PHYTOMEDICINE,      [PMID:36332391] [10.1016/j.phymed.2022.154519]

10. Kai-Wen Ren, Xiao-Hong Yu, Yu-Hui Gu, Xin Xie, Yu Wang, Shi-hao Wang, Hui-Hua Li, Hai-Lian Bi.  (2022)  Cardiac-specific knockdown of Bhlhe40 attenuates angiotensin II (Ang II)-Induced atrial fibrillation in mice.  Frontiers in Cardiovascular Medicine,      [PMID:36304536] [10.3389/fcvm.2022.957903]

11. Na Yang, Chunpeng Zou, Wu Luo, Diyun Xu, Mengyang Wang, Yi Wang, Gaojun Wu, Peiren Shan, Guang Liang.  (2022)  Sclareol attenuates angiotensin II-induced cardiac remodeling and inflammation via inhibiting MAPK signaling.  PHYTOTHERAPY RESEARCH,  37  (2): (578-591).  [PMID:36178264] [10.1002/ptr.7635]

12. Yawen Deng, Zhitong Li, Xiangbo An, Rui Fan, Yao Wang, Jiatian Li, Xiaolei Yang, Jiawei Liao, Yunlong Xia.  (2022)  Hyperhomocysteinemia Promotes Cardiac Hypertrophy in Hypertension.  Oxidative Medicine and Cellular Longevity,      [PMID:36046692] [10.1155/2022/1486157]

13. Xin Xie, Ting-ting Shen, Hai-lian Bi, Zhuo-lin Su, Zi-qi Liao, Ying Zhang, Lei Shi, Yun-long Xia.  (2022)  Melatonin inhibits angiotensin II–induced atrial fibrillation through preventing degradation of Ang II Type I Receptor–Associated Protein (ATRAP).  BIOCHEMICAL PHARMACOLOGY,      [PMID:35710020] [10.1016/j.bcp.2022.115146]

14. Mengyang Wang, Wu Luo, Tianxiang Yu, Shiqi Liang, Jinfeng Sun, Yi Zhang, Xue Han, Xiaohong Long, Guang Liang, Gao Li.  (2022)  Corynoline protects ang II-induced hypertensive heart failure by increasing PPARα and Inhibiting NF-κB pathway.  BIOMEDICINE & PHARMACOTHERAPY,      [PMID:35658238] [10.1016/j.biopha.2022.113075]

15. Guangquan Hu, Xiaojie Ding, Feng Gao, Jiehua Li.  (2022)  Calcium and integrin binding protein 1 (CIB1) induces myocardial fibrosis in myocardial infarction via regulating the PI3K/Akt pathway.  EXPERIMENTAL ANIMALS,      [PMID:34349085] [10.1538/expanim.21-0063]

16. Jinfu Qian, Wu Luo, Chengyi Dai, Jun Wang, Xinfu Guan, Chunpeng Zou, Nipon Chattipakorn, Gaojun Wu, Weijian Huang, Guang Liang.  (2020)  Myeloid differentiation protein 2 mediates angiotensin II-induced inflammation and mesenchymal transition in vascular endothelium.  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,      [PMID:33338595] [10.1016/j.bbadis.2020.166043]

17. Ke Lin, Wu Luo, Jueqian Yan, Siyuan Shen, Qirui Shen, Jun Wang, Xinfu Guan, Gaojun Wu, Weijian Huang, Guang Liang.  (2020)  TLR2 regulates angiotensin II-induced vascular remodeling and EndMT through NF-κB signaling.  Aging-US,      [PMID:33318302] [10.18632/aging.202290]

18. Zhengyong Wang, Yuqi Cao, Yingjie Lu, Fang Zhang, Yue Su, Yinlong Guo.  (2020)  Ultrasonic extraction and nebulization in real-time coupled with carbon fiber ionization mass spectrometry for rapid screening of the synthetic drugs adulterated into herbal products.  ANALYTICA CHIMICA ACTA,      [PMID:33081950] [10.1016/j.aca.2020.08.045]

19. Guo Xiao, Zhang Yongtao, Lu Changhong, Qu Fengxia, Jiang Xianyan.  (2020)  Protective effect of hyperoside on heart failure rats via attenuating myocardial apoptosis and inducing autophagy.  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,  84  (4): (714-724).  [PMID:31797747] [10.1080/09168451.2019.1685369]

20. Rui Guo, Ningning Liu, Hao Liu, Junhua Zhang, Han Zhang, Yingchao Wang, Mirko Baruscotti, Lu Zhao, Yi Wang.  (2020)  High content screening identifies licoisoflavone A as a bioactive compound of Tongmaiyangxin Pills to restrain cardiomyocyte hypertrophy via activating Sirt3.  PHYTOMEDICINE,      [PMID:32018211] [10.1016/j.phymed.2020.153171]

21. Jing Yang, Wenpeng Zhang, Hongjun Zhang, Minlin Zhong, Wenbo Cao, Zishuai Li, Xi Huang, Zongxiu Nie, Jiaming Liu, Peng Li, Xiaoxiao Ma, Zheng Ouyang.  (2019)  Polydopamine-Modified Substrates for High-Sensitivity Laser Desorption Ionization Mass Spectrometry Imaging.  ACS Applied Materials & Interfaces,      [PMID:31729222] [10.1021/acsami.9b16260]

22. Xin Xie, Hai-Lian Bi, Song Lai, Yun-Long Zhang, Nan Li, Hua-Jun Cao, Ling Han, Hong-Xia Wang, Hui-Hua Li.  (2019)  The immunoproteasome catalytic β5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation.  Science Advances,  5  (5):   [PMID:31086810] [10.1126/sciadv.aau0495]

23. Zheng Xu, Chunpeng Zou, Weihui Yu, Sujing Xu, Lan Huang, Zia Khan, Jingying Wang, Guang Liang, Yi Wang.  (2019)  Inhibition of STAT3 activation mediated by toll-like receptor 4 attenuates angiotensin II-induced renal fibrosis and dysfunction.  BRITISH JOURNAL OF PHARMACOLOGY,  176  (14): (2627-2641).  [PMID:30958891] [10.1111/bph.14686]

24. Dandan Chen, Zhe Li, Peiqing Bao, Miao Chen, Miao Zhang, Fangrong Yan, Yitao Xu, Caoyu Ji, Xinyue Hu, Daniel Sanchis, Yubin Zhang, Junmei Ye.  (2019)  Nrf2 deficiency aggravates Angiotensin II-induced cardiac injury by increasing hypertrophy and enhancing IL-6/STAT3-dependent inflammation.  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,      [PMID:30668979] [10.1016/j.bbadis.2019.01.020]

25. Qing Shu, Song Lai, Xiao-Mei Wang, Yun-Long Zhang, Xiao-Lei Yang, Hai-Lian Bi, Hui-Hua Li.  (2018)  Administration of ubiquitin-activating enzyme UBA1 inhibitor PYR-41 attenuates angiotensin II-induced cardiac remodeling in mice.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,      [PMID:30249396] [10.1016/j.bbrc.2018.09.100]

26. Hong Jiang, Chen Zhang, Wen He.  (2018)  The Effects of Dracocephalum Heterophyllum Benth Flavonoid on Hypertrophic Cardiomyocytes Induced by Angiotensin II in Rats.  MEDICAL SCIENCE MONITOR,      [PMID:30199522] [10.12659/MSM.908912]

27. Fan Chen, Dandan Chen, Yubin Zhang, Liang Jin, Han Zhang, Miyang Wan, Tianshu Pan, Xiaochuan Wang, Yuheng Su, Yitao Xu, Junmei Ye.  (2017)  Interleukin-6 deficiency attenuates angiotensin II-induced cardiac pathogenesis with increased myocyte hypertrophy.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,      [PMID:29079193] [10.1016/j.bbrc.2017.10.119]

28. Xing-Li PEI, Yu-Yu HUANG, Can GONG, Xu XU.  (2017)  Matrix-assisted Laser Desorption/Ionization-Mass Spectrometry Imaging of Oligosaccharides in Soybean and Bean Leaf with Ionic Liquid as Matrix.  CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,      [PMID:] [10.1016/S1872-2040(17)61031-4]

29. Xinming Huo, Jin Chen, Fei Tang, Tongtong Yao, Shiyun Piao, Kai Ni, Xiaohao Wang.  (2017)  Rapid mass spectrometry analysis of a rectilinear ion trap by continuous secular frequency scanning.  RAPID COMMUNICATIONS IN MASS SPECTROMETRY,  31  (12): (1031-1040).  [PMID:28403552] [10.1002/rcm.7880]

30. Zhengge Chen, Yi Hong, Futao Lin, Xiongfei Zha, Fengcheng Lin, Yang Li, Bin Hu, Qi Huang, Lei Li, Zhengxu Huang, Li Ding, Zhen Zhou.  (2025)  An Ultra-High-Resolution Mass Spectrometer with an Intermediate-Pressure Matrix-Assisted Laser Desorption/Ionization Source.  ANALYTICAL CHEMISTRY,      [PMID:40082255] [10.1021/acs.analchem.5c00006]

31. Wanyue Sang, Xiaoji Yan, Lu Wang, Huaxin Sun, Yi Jian, Feifei Wang, Baopeng Tang, Yaodong Li.  (2024)  CALCOCO2 prevents AngII-induced atrial remodeling by regulating the interaction between mitophagy and mitochondrial stress.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:39094358] [10.1016/j.intimp.2024.112841]

32. Zihan Wei, Ying Lu, Cheng Qian, Jing Li.  (2024)  Circ_0079480 facilitates proliferation, migration and fibrosis of atrial fibroblasts in atrial fibrillation by sponing miR-338-3p to activate the THBS1/TGF-β1/Smad3 signaling.  INTERNATIONAL JOURNAL OF CARDIOLOGY,      [PMID:39187069] [10.1016/j.ijcard.2024.132486]

33. Pingping Tuo, Risheng Zhao, Ning Li, Shuang Yan, Gege Yang, Chunmei Wang, Jinghui Sun, Haiming Sun, Mengyang Wang.  (2024)  Lycorine inhibits Ang II-induced heart remodeling and inflammation by suppressing the PI3K-AKT/NF-κB pathway.  PHYTOMEDICINE,      [PMID:38484625] [10.1016/j.phymed.2024.155464]

34. Meili Zhu, Jiangbiao Hu, Yifan Pan, Qian Jiang, Chang Shu.  (2024)  Magnoflorine attenuates Ang II-induced cardiac remodeling via promoting AMPK-regulated autophagy.  Cardiovascular Diagnosis and Therapy,  14  (4): (576).  [PMID:39263476] [10.21037/cdt-24-130]

35. Lu Wang, Wanyue Sang, Yi Jian, Yafan Han, Feifei Wang, Subinuer Wubulikasimu, Li Yang, Baopeng Tang, Yaodong Li.  (2024)  MAPK14/AIFM2 pathway regulates mitophagy-dependent apoptosis to improve atrial fibrillation.  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,      [PMID:39657863] [10.1016/j.yjmcc.2024.12.002]

36. Xiao-Xiao Jiang, Ri Zhang, Hui-Shan Wang.  (2024)  Neferine mitigates angiotensin II-induced atrial fibrillation and fibrosis via upregulation of Nrf2/HO-1 and inhibition of TGF-β/p-Smad2/3 pathways.  Aging-US,      [PMID:38775722] [10.18632/aging.205829]

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