Apamin TFA - ≥96% , CAS No.A659185

CAS: A659185 Cat. No.: A659185 Formule: C₈₁H₁₃₂F₃N₃₁O₂₆S₄ Poids moléculaire: 2141.36

QUALITÉ & PURETÉ ≥96%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca 2+ -activated K + (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity.

Appearance:Solid

IC50& Target:K + channel

In Vitro:Apamin (0.5-2 µg/mL; 24 hours; HSC-T6 cells) treatment markedly reduces the expression of α-SMA in the TGF-β1-induced HSC-T6 cells. Apamin treatment abrogats the activation of p-Smad2/3 and Smad4 induced by TGF-β1. MCE has not independently confirmed

In Vivo:Apamin (0.1mg/kg; intraperitoneal injection; twice a week; for 4 weeks; C57BL/6 male mice) treatment results in decreased liver injury and proinflammatory cytokine levels. Apamin suppresses the deposition of collagen, proliferation of BECs and expression

Biological Activity:Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca 2+ -activated K + (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity.

Spécifications

Spécifications et pureté

≥96%

Conditions de stockage de stockage

Desiccated,Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Pureté

≥96%

Noms et identifiants

Poids moléculaire

2141.36

Propriétés chimiques et physiques

• Solubilité: H2O : 50 mg/mL (23.35 mM; Need ultrasonic)