AR7 - ≥96% , CAS No.80306-38-3

CAS: 80306-38-3 Cat. No.: A413542 Formule: C₁₅H₁₂ClNO Poids moléculaire: 257.71 Numéro CE: 806-133-8

GRADE & PURITY ≥96%

Synonyms

MFCD27978377 | SCHEMBL12206685 | 7-chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine | AKOS032946191 | EX-A1249 | BCP25687 | HY-101106 | AR7 | AR-7 | 7-Chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine | 7-chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine | NCGC00347937-01 |

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Information

AR7 AR7 is a retinoic acid receptor α (RARα) antagonist.

application：

AR7 has been used:

• as chaperone-mediated autophagy (CMA) activator to study the activity of CMA in rat liver lysosomes

• as a CMA activator to study its effects on expression of DEAD-box helicase 3 X-linked (DDX3X), eukaryotic translation initiation factor 4A1 (EIF4A1), and eukaryotic translation initiation factor 4H (EIF4H) in cancer cells

• to study its effects on synuclein α (SNCA) oligomer levels in mature primary cortical neurons

Specifications

Synonymes

MFCD27978377 | SCHEMBL12206685 | 7-chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine | AKOS032946191 | EX-A1249 | BCP25687 | HY-101106 | AR7 | AR-7 | 7-Chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine | 7-chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine | NCGC00347937-01 |

Spécifications et pureté

≥96%

Mécanismes biochimiques et physiologiques

AR7 is a retinoic acid receptor α (RARα) antagonist.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

ANTAGONIST

Pureté

≥96%

Noms et identifiants

• Pubchem Sid: 504770334
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504770334
• Sourires canoniques: CC1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)Cl)OC2
• IUPAC Name: 7-chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine
• InChIKey: MVOZLTFXYGHZPM-UHFFFAOYSA-N
• INCHI: 1S/C15H12ClNO/c1-10-2-4-11(5-3-10)14-9-18-15-8-12(16)6-7-13(15)17-14/h2-8H,9H2,1H3
• Isomères SMILES: CC1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)Cl)OC2
• WGK Allemagne: 3
• Poids moléculaire: 257.71
• Reaxy-Rn: 20039175
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20039175&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Benzoxazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Benzoxazines
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzoxazines
• Alternative Parents: Toluenes Alkyl aryl ethers Aryl chlorides Ketimines Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Azacyclic compounds Organochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzoxazine - Alkyl aryl ether - Toluene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Benzenoid - Ketimine - Oxacycle - Azacycle - Ether - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Hydrocarbon derivative - Imine - Organic oxygen compound - Organohalogen compound - Organochloride - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as benzoxazines. These are organic compounds containing a benzene fused to an oxazine ring (a six-membered aliphatic ring with four carbon atoms, one oxygen atom, and one nitrogen atom).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Solubility (25°C) In vitro DMSO: 4 mg/mL (15.52 mM); Water: Insoluble; Ethanol: Insoluble
• Poids moléculaire: 257.709 g/mol
• XLogP3: 4.100
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 257.061 Da
• Monoisotopic Mass: 257.061 Da
• Topological Polar Surface Area: 21.600 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 322.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Foire aux questions

What is the purity of this product?

This product is supplied at ≥96% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 80306-38-3, the molecular formula is C15H12ClNO, and the molecular weight is 257.71 g/mol. InChIKey MVOZLTFXYGHZPM-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.