AR7 - 10mM in DMSO , CAS No.80306-38-3

CAS: 80306-38-3 Cat. No.: A426075 Formule: C₁₅H₁₂ClNO Poids moléculaire: 257.71 Numéro CE: 806-133-8

GRADE & PURITY 10mM in DMSO

Synonyms

MFCD27978377 | SCHEMBL12206685 | 7-chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine | AKOS032946191 | EX-A1249 | BCP25687 | HY-101106 | AR7 | AR-7 | 7-Chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine | 7-chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine | NCGC00347937-01 |

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Information

AR7 AR7 is a retinoic acid receptor α (RARα) antagonist.

application：

AR7 has been used:

• as chaperone-mediated autophagy (CMA) activator to study the activity of CMA in rat liver lysosomes

• as a CMA activator to study its effects on expression of DEAD-box helicase 3 X-linked (DDX3X), eukaryotic translation initiation factor 4A1 (EIF4A1), and eukaryotic translation initiation factor 4H (EIF4H) in cancer cells

• to study its effects on synuclein α (SNCA) oligomer levels in mature primary cortical neurons

Specifications

Synonymes

MFCD27978377 | SCHEMBL12206685 | 7-chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine | AKOS032946191 | EX-A1249 | BCP25687 | HY-101106 | AR7 | AR-7 | 7-Chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine | 7-chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine | NCGC00347937-01 |

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

AR7 is a retinoic acid receptor α (RARα) antagonist.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

ANTAGONIST

Noms et identifiants

• Pubchem Sid: 528763121
• Sourires canoniques: CC1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)Cl)OC2
• IUPAC Name: 7-chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine
• InChIKey: MVOZLTFXYGHZPM-UHFFFAOYSA-N
• INCHI: 1S/C15H12ClNO/c1-10-2-4-11(5-3-10)14-9-18-15-8-12(16)6-7-13(15)17-14/h2-8H,9H2,1H3
• Isomères SMILES: CC1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)Cl)OC2
• WGK Allemagne: 3
• Poids moléculaire: 257.71
• Reaxy-Rn: 20039175
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20039175&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Benzoxazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Benzoxazines
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzoxazines
• Alternative Parents: Toluenes Alkyl aryl ethers Aryl chlorides Ketimines Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Azacyclic compounds Organochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzoxazine - Alkyl aryl ether - Toluene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Benzenoid - Ketimine - Oxacycle - Azacycle - Ether - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Hydrocarbon derivative - Imine - Organic oxygen compound - Organohalogen compound - Organochloride - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as benzoxazines. These are organic compounds containing a benzene fused to an oxazine ring (a six-membered aliphatic ring with four carbon atoms, one oxygen atom, and one nitrogen atom).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mécanismes d'action

Propriétés chimiques et physiques

• Poids moléculaire: 257.709 g/mol
• XLogP3: 4.100
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 257.061 Da
• Monoisotopic Mass: 257.061 Da
• Topological Polar Surface Area: 21.600 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 322.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1