Arecoline - Moligand™, 10 mM in DMSO , CAS No.63-75-2

CAS: 63-75-2 Cat. No.: A1499917 Formule: C₈H₁₃NO₂ Poids moléculaire: 155.19 Numéro CE: 200-565-5

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Arecoline, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor . Arecoline exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline also can induce oxidative stress .

Specifications

Spécifications et pureté

Moligand™, 10 mM in DMSO

Conditions de stockage de stockage

Protected from light,Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Propriétés du produit

• pKa: pKa: 6.84
• Ki Data: Muscarinic acetylcholine receptor M1: Ki= 3.33 nM (Mus musculus); Muscarinic acetylcholine receptor: Ki= 5.3 nM (rat); Muscarinic acetylcholine receptor M3: Ki= 7.4 nM (rat); Muscarinic acetylcholine receptor M4: Ki= 7.4 nM (rat)

Noms et identifiants

• Isomères SMILES: CN1CCC=C(C1)C(=O)OC
• CAS alternatif: 300-08-3
• Poids moléculaire: 155.19
• Reaxy-Rn: 123045
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=123045&ln=

Propriétés chimiques et physiques

• Indice de réfraction: n20D1.48 (Predicted)
• Point d'ébullition (°C): 209° C
• Point de fusion (°C): 27.46° C (Predicted)

Références

1. Ying Lu, Jianna Yu, Wen Liu, Guoxing Jing, Wenshan Li, Wenjie Liu.  (2022)  Quantitative determination of major alkaloids in areca nut products by high-performance liquid chromatography coupled with ion mobility spectrometry.  JOURNAL OF SEPARATION SCIENCE,  45  (24): (4469-4477).  [PMID:36250424] [10.1002/jssc.202200361]

2. Yin Lifen, Wang Xiao.  (2024)  Curcumin Alleviates Arecoline-induced Oral Submucous Fibrosis via the FOSL1/MAPK8 Axis.  CELL BIOCHEMISTRY AND BIOPHYSICS,      [PMID:39674970] [10.1007/s12013-024-01633-x]

3. Kaiping Xiang, Bing Wang, Lanying Wang, Yunfei Zhang, Hanzeng Li, Yanping Luo.  (2024)  Oxidative Stress, Oxidative Damage, and Cell Apoptosis: Toxicity Induced by Arecoline in Caenorhabditis elegans and Screening of Mitigating Agents.  Toxins,  16  (8): (352).  [PMID:39195762] [10.3390/toxins16080352]

4. Sun Honglan, Yang Chao, Yin Xiaoyunqing, Chen Shizhao, Huang Yuqi, Kuang Huifang, Luo Wen.  (2025)  VHL ameliorates arecoline-induced oral submucosal fibrosis by promoting HDAC6 ubiquitination and blocking NF-κB pathway.  Scientific Reports,  15  (1): (1-12).  [PMID:40038412] [10.1038/s41598-025-91207-5]

5. Yuejie Wu, Fei Wang, Longxiang Gao, Yunfei Zhang, Lanying Wang, Yanping Luo.  (2025)  Evaluation of the Intergenerational Effects of Arecoline on Aedes aegypti via Acute Exposure and Its Role in Inducing the Leg Deformities Involved in Chitin Synthesis Inhibition.  ENVIRONMENTAL TOXICOLOGY,      [PMID:41427474] [10.1002/tox.70013]

6. Ting-Syuan Lin, Jingting Wan, Jingjin He, Shidong Cui, Yun Huang, Bojian Zhang, Hsi-Yuan Huang, Kexin Zhu, Jihang Chen, Tao Zhang, Shangfu Li, Liao Hu, Yongfei Wang, Hsien-Da Huang, Ping Tang, Yang-Chi-Dung Lin.  (2026)  Arecoline as a Novel Scaffold Targeting the ATAD2 Bromodomain for Cell Cycle Modulation.  Pharmaceutics,  18  (3): (324).  [PMID:41900810] [10.3390/pharmaceutics18030324]

Foire aux questions

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 63-75-2, the molecular formula is C8H13NO2, and the molecular weight is 155.19 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.