Asaraldehyde - 10mM in DMSO , CAS No.4460-86-0

CAS: 4460-86-0 Cat. No.: A408453 Formule: C₁₀H₁₂O₄ Poids moléculaire: 196.2 Beilstein Registry Number: 1951403 Numéro CE: 224-713-3 PubChem CID: 20525

GRADE & PURITY 10mM in DMSO

Synonyms

Asaronaldehyde | 2,​4,​5-​trimethoxy-benzaldehyde

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Information

Asaraldehyde (Asaronaldehyde) is a naturalCOX-2inhibitor, exhibiting 17-fold selectivity over COX-1.
In vitro

Asaraldehyde is found to be the most abundant constituent, but is totally absent in its cultured broth and its natural host, C. kanehirae wood. On feeding with the acid-digested sawdust of C. kanehirae wood or vanillin to the broth for culture, Asaraldehyde is produced in both cultured broths. Asaraldehyde shows 3.32% of prostaglandin H endoperoxide synthase-1 (COX-1) inhibitory activity and 52.69% prostaglandin H endoperoxide synthase-2 (COX-2) inhibitory activity, respectively at 100 mg/mL. Asaraldehyde shows selectivity towards COX-2 enzyme inhibition at 100 µg/mL. The COX-2/COX-1 ratio for Asaraldehyde is 17.68 at 100 µg/mL compared to solvent control. Asaraldehyde down-regulates C/EBPβ, C/EBPδ, and C/EBPα. Asaraldehyde suppresses expression of PPARγ1 and PPARγ2. Asaraldehyde also significantly suppresses the expression of acetyl-CoA carboxylase (ACC).

In vivo

Cell Data

cell lines：VSMC cells

Concentrations：100 μg/mL

Incubation Time：24 hours

Powder Purity:≥100%

Specifications

Synonymes

Asaronaldehyde | 2,​4,​5-​trimethoxy-benzaldehyde

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

Asaraldehyde (Asaronaldehyde) is a natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Noms et identifiants

• Isomères SMILES: COC1=CC(=C(C=C1C=O)OC)OC
• WGK Allemagne: 3
• RTECS: CU8460000
• PubChem CID: 20525
• Poids moléculaire: 196.2
• Beilstein: 1951403
• Reaxy-Rn: 1951403

Propriétés chimiques et physiques

• Solubilité: Solubility (25°C) In vitro DMSO: 2 mg/mL (5.99 mM); Water: Insoluble; Ethanol: Insoluble
• Point d'ébullition (°C): 140 °C/4 mmHg
• Point de fusion (°C): 109-112°C

Foire aux questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 4460-86-0, the molecular formula is C10H12O4, and the molecular weight is 196.2 g/mol.