Atuliflapon - 10mM in DMSO , CAS No.2041075-86-7

CAS: 2041075-86-7 Cat. No.: A656323 Molecular Weight: 446.50 PubChem CID: 122678117

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Atuliflapon (AZD5718) is an orally active inhibitor of FLAP (5‑Lipoxygenase activating protein) , with an IC 50 of 2 nM. Atuliflapon is used in the study for coronary artery disease

In Vitro

Atuliflapon demonstrates a dose dependent and greater than 90% suppression of leukotriene production over 24 h. Atuliflapon exhibits an IC 50 of 39 nM for LTB 4. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Atuliflapon exhibits t1/2 of 0.45 h and 2.1 h in rat and dog by iv injection, respectively . Atuliflapon shows no inhibition of 5-LO pathway activity in rodent blood . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 2 nM (FLAP)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Atuliflapon (AZD5718) is an orally active inhibitor of FLAP (5‑Lipoxygenase activating protein) , with an IC 50 of 2 nM. Atuliflapon is used in the study for coronary artery disease.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CC1=CC(=NN1)C2=CC=C(C=C2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4=C5C(=O)NCCN5N=C4
• Alternate CAS: 2041075-86-7
• PubChem CID: 122678117
• MeSH Entry Terms: AZD5718
• Molecular Weight: 446.50

Associated Targets(Human)

ALOX5AP Tchem Arachidonate 5-lipoxygenase-activating protein (0 Activities)

Discover Target: ALOX5AP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)