Balixafortide TFA - Moligand™, ≥98% , CAS No.1051366-32-5(free base)

CAS: 1051366-32-5(free base) Cat. No.: B658810 Molecular Weight: 1864.11(free base)

GRADE & PURITY Moligand™, ≥98%

Synonyms

POL6326 TFA

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC 50 < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7 . Balixafortide TFA blocks β-arre

Appearance:Solid

IC50& Target:CXCR4 <10 nM (IC 50 )

In Vitro:Balixafortide potently inhibits pERK / pAKT signaling in the lymphoma lines Namalwa (IC 50 < 200 nM) and Jurkat (IC 50 < 400 nM). Balixafortide efficiently blocks SDF-1 dependent chemotaxis of MDA MB 231 breast cancer cells (IC 50 < 20 nM), Namalwa and Ju

In Vivo:Balixafortide is optimized for favorable mouse absorption, distribution, metabolism and excretion (ADME) properties with balanced plasma protein binding, greater plasma and microsomal stability. MCE has not independently confirmed the accuracy of the

Biological Activity:Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC 50 < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7 . Balixafortide TFA blocks β-arre

Specifications

Synonyms

POL6326 TFA

Specifications & Purity

Moligand™, ≥98%

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ANTAGONIST

Purity

≥98%

Names and Identifiers

• Molecular Weight: 1864.11(free base)

Chemical and Physical Properties

• Solubility: H2O : 100 mg/mL (50.55 mM; Need ultrasonic) DMSO : 100 mg/mL (50.55 mM; Need ultrasonic)
• Sensitivity: Light sensitive；Moisture sensitive