Beraprost sodium - 10mM in DMSO , CAS No.496807-11-5

CAS: 496807-11-5 Cat. No.: B656631 Formule: C₂₄H₂₉NaO₅ Poids moléculaire: 420.47 PubChem CID: 101623382

GRADE & PURITY 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Beraprost sodium, a prostacyclin analog, is a stable and orally active proagent of PGI2 . Beraprost sodium is a potent vasodilator , has the potential for pulmonary arterial hypertension treatment through expanding renal vessels, improving microcirculation

In Vitro

Beraprost sodium (0.1, 1.0, and 10.0 μM; 24 hours) treatment leads to a significant increase in the number of tube formation, BPS plays an important role on angiogenic activity. Beraprost sodium (0.1, 1.0, and 10.0 μM; 24 hours) treatment let VE-cadherin at regions of cell–cell contact becomes more abundant and the morphology of endothelial cells tends to be normal compared with those cultured under hypoxia conditions. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Beraprost sodium (oral adminstration; 0.6 mg/kg; once daily; 3 or 7 days) can mitigate the development of renal interstitial fibrosis, decrease renal oxidative stress through its potential vasodilation effect, and further prevent renal interstitial fibrosis . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-8-week-old C57Bl/6J Male Mice Dosage: 0.6 mg/kg Administration: Oral adminstration; 0.6 mg/kg; once daily; 3 or 7 days Result: Mitigated the development of renal interstitial fibrosis.

IC50& Target:IP

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

Beraprost sodium, a prostacyclin analog, is a stable and orally active proagent of PGI2 . Beraprost sodium is a potent vasodilator , has the potential for pulmonary arterial hypertension treatment through expanding renal vessels, improving microcirculatio

Conditions de stockage de stockage

Desiccated,Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Noms et identifiants

Isomères SMILES

CC#CCC(C)[C@H](/C=C/[C@@H]1[C@H](C[C@@H]2[C@H]1C3=CC=CC(=C3O2)CCCC(=O)[O-])O)O.[Na+]

PubChem CID

101623382

Termes d'entrée MeSH

4-(1,2,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyloct-6-yne-1-enyl)-5-cyclopenta(b)benzofuranyl)butyrate;beraprost;beraprost sodium;TRK 100;TRK-100

Poids moléculaire

420.47