BI-2545 - ≥99% , CAS No.2162961-71-7

CAS: 2162961-71-7 Cat. No.: B649217 Formule: C₂₃H₁₉F₆N₅O₃ Poids moléculaire: 527.42

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC 50 s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively

In Vitro

BI-2545 displays good potency in the LPA and rat whole blood assay with IC 50 s of 29 nM and 96 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BI-2545 (10 mg/kg; p.o.) has high and sustained in vivo efficacy in reducing LPAs . BI-2545 (10 mg/kg; p.o.) has a half-life of t 1/2 =3.4 hours . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rat Dosage: 10 mg/kg Administration: Oral administration Result: Reduces the sum of the plasma LPA species up to 90%.

Form:Solid

IC50& Target:C50: 2.2 nM (human ATX), 3.4 nM (rat ATX)

Specifications

Spécifications et pureté

≥99%

Mécanismes biochimiques et physiologiques

BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC 50 s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Pureté

≥99%

Noms et identifiants

• Poids moléculaire: 527.42

Propriétés chimiques et physiques

• Solubilité: DMSO : 250 mg/mL (474.01 mM; Need ultrasonic)