Blasticidin S hydrochloride solution - 10 mg/mL in 20 mM HEPES , CAS No.3513-03-9

CAS: 3513-03-9 Cat. No.: B276563 Molecular Weight: 458.9 EC Number: 609-067-6 PubChem CID: 75412545

GRADE & PURITY 10 mg/mL in 20 mM HEPES

Synonyms

(2S,3S,6R)-3-[[(3S)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid;hydrochloride | blasticidin S HCl | (2S,3S,6R)-6-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-[(3S)-3-amino-5-

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.

Specifications

Synonyms

(2S, 3S, 6R)-3-[[(3S)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3, 6-dihydro-2H-pyran-2-carboxylic acid;hydrochloride | blasticidin S HCl | (2S, 3S, 6R)-6-(4-amino-2-oxo-1, 2-dihydropyrimidin-1-yl)-3-[(3S)-3-amino-5-

Specifications & Purity

10 mg/mL in 20 mM HEPES

Biochemical and Physiological Mechanisms

Broad spectrum amino nucleoside antibiotic agent similar to puromycin . Inhibits protein biosynthesis at both prokaryotic and eukaryotic ribosomes. Also available as a solid .

Storage

Protected from light, Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Names and Identifiers

• Canonical Smiles: CN(CCC(CC(=O)NC1C=CC(OC1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N.Cl
• IUPAC Name: (2S,3S,6R)-3-[[(3S)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid;hydrochloride
• InChIKey: YQXYQOXRCNEATG-NMQKUDMSSA-N
• INCHI: 1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10-,13+,14-;/m0./s1
• Isomeric SMILES: CN(CC[C@@H](CC(=O)N[C@H]1C=C[C@@H](O[C@@H]1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N.Cl
• WGK Germany: 2
• PubChem CID: 75412545
• Molecular Weight: 458.9

Chemical and Physical Properties

• Solubility: Supplied in 20 mM aqueous HEPES, pH 7.0 (10 mg/ml)
• Sensitivity: light sensitive；heat sensitive；air sensitive
• Refractive Index: 1.71
• Boil Point(°C): 772.1 °C at 760 mmHg
• Molecular Weight: 458.900 g/mol
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 458.179 Da
• Monoisotopic Mass: 458.179 Da
• Topological Polar Surface Area: 213.000 Ų
• Heavy Atom Count: 31
• Formal Charge: 0
• Complexity: 795.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Xinyi Song, Haipeng Rao, Chunchun Huang, Miaoling Huang, Ying Ma, Jingyu Xin, Jiajia Hou, Zhigang Hu, Lingfeng He, Feiyan Pan, Lingdong Yang, Zhigang Guo.  (2025)  P4HB, a novel succinated protein, is essential for fumarate-induced cancer metastasis.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40318732] [10.1016/j.ijbiomac.2025.143885]