Bocidelpar - Moligand™,≥98% , CAS No.2095128-20-2

CAS: 2095128-20-2 Cat. No.: B648929 Formule: C₂₅H₂₇F₃N₂O₃ Poids moléculaire: 460.49 PubChem CID: 126752383

QUALITÉ & PURETÉ Moligand™, ≥98%

Synonyms

(R)-3-Methyl-6-(2-((5-methyl-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid | ASP0367 | MA-0211 | SP-0367

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Bocidelpar is a selective PPARδ modulator. Bocidelpar activates the PPARδ downstream signaling pathway, upregulates the expression of target genes such as ABCA1 and ACAA2. Bocidelpar then promotes fatty acid oxidation (FAO) and mitochondrial biogenesis, and improves mitochondrial dysfunction. Bocidelpar can improve mitochondrial biogenesis and function in muscle cells. Bocidelpar is mainly used in the study of mitochondrial dysfunction diseases such as primary mitochondrial myopathy (PMM) and Duchenne muscular dystrophy (DMD).

Spécifications

Synonymes

(R)-3-Methyl-6-(2-((5-methyl-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid | ASP0367 | MA-0211 | SP-0367

Spécifications et pureté

Moligand™,≥98%

Mécanismes biochimiques et physiologiques

Bocidelpar is a modulator of peroxisome proliferator-activated receptor delta ( PPAR-δ ). Bocidelpar improves mitochondrial biogenesis and function in Duchenne Muscular Dystrophy (DMD) muscle cells (extracted from patent WO2017062468A1, compound 2b).

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

MODULATOR

Pureté

≥98%

Noms et identifiants

Isomères SMILES

CC1=CN=C(N1CC2=CC=CC=C2OCCC[C@@H](C)CC(=O)O)C3=CC=C(C=C3)C(F)(F)F

PubChem CID

126752383

Poids moléculaire

460.49

Propriétés chimiques et physiques

• Solubilité: DMSO : 250 mg/mL (542.90 mM; Need ultrasonic)
• Poids moléculaire: 460.500 g/mol
• XLogP3: 5.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 10
• Exact Mass: 460.197 Da
• Monoisotopic Mass: 460.197 Da
• Topological Polar Surface Area: 64.400 Ų
• Heavy Atom Count: 33
• Formal Charge: 0
• Complexity: 610.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1