Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Argon charged,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 4 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Brusatol (NSC?172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent. Brusatol increases cellular apoptosis.
| Isomeric SMILES | CC1=C(C(=O)C[C@]2([C@H]1C[C@@H]3[C@]45[C@@H]2[C@H]([C@@H]([C@]([C@@H]4[C@H](C(=O)O3)OC(=O)C=C(C)C)(OC5)C(=O)OC)O)O)C)O |
|---|---|
| Molecular Weight | 520.53 |
| Reaxy-Rn | 25075818 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25075818&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| 1. Wang Zhi-shun, Shu Bo, Han Qi, Li Guo-hao, Guo Yong-lian. (2023) Effects of grape seed-derived proanthocyanidin B2 pretreatment on oxidative stress, endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells in renal ischemia–reperfusion injury model of mice. INTERNATIONAL UROLOGY AND NEPHROLOGY, [PMID:36935438] [10.1007/s11255-023-03494-4] |
| 2. Na Wei, Tan Lu, Libin Yang, Yonghan Dong, Xiaotan Liu. (2021) Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway. FEBS Open Bio, 11 (8): (2118-2126). [PMID:34048148] [10.1002/2211-5463.13203] |
| 3. Mengmeng Zhang, Tianchui Wang, Sixian Ou, Yucong Zou, Xuan Xin. (2024) Betaine activates the Nrf2-Keap1-ARE pathway by increasing the methylation level of Keap1 DNA promoter. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 59 (9): (6231-6242). [PMID:] [10.1111/ijfs.17359] |
| 4. Zhi-shun Wang, Qi Han, Hao Shen, Bo Shu, Cheng-cheng Ying, Guo-hao Li, Yong-lian Guo. (2025) Impact of grape seed proanthocyanidin B2 pretreatment on mitochondrial oxidative stress, endoplasmic reticulum stress, and apoptosis in renal tubular epithelial cells during in-vitro hypoxia-reoxygenation. Acta Cirurgica Brasileira, [PMID:40498953] [10.1590/acb404125] |
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
View Moligand™ grade guide →
