Burimamide oxalate - Moligand™ , Agonist of H 2 receptor;Antagonist of H 2 receptor;Antagonist of H 3 receptor;Antagonist of H 4 receptor, CAS No.34970-69-9, Agonist of H 2 receptor;Antagonist of H 2 receptor;Antagonist of H 3 receptor;Antagonist of H 4 receptor

CAS: 34970-69-9 Cat. No.: B339433 Formule: C₉H₁₆N₄S•C₂H₂O₄ Poids moléculaire: 302.35

GRADE & PURITY Moligand™

Synonyms

N-(4-imidazol-4-ylbutyl)-N'-methylthiourea | UNII-TN5A4OD2TV | BDBM22888 | CHEBI:3221 | DTXSID00188519 | N-methyl-N'-[4-(4-imidazolyl)butyl]thiourea | N-METHYL-N'-(4(5)-IMIDAZOLYLBUTYL)THIOUREA | PDSP2_001081 | PDSP1_001097 | BDBM50483128 | Q3268750 | THI

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Vue d’ensemble

Burimamide oxalate is a mixed Histamine H|3|Receptor and Histamine H|2|Receptor(H|2|/H|3|) antagonist. In SK-N-MC cells, this compound displays partial agonist activity. Burimamide oxalate also produces antinicoceptive effects.

Specifications

Synonymes

N-(4-imidazol-4-ylbutyl)-N'-methylthiourea | UNII-TN5A4OD2TV | BDBM22888 | CHEBI:3221 | DTXSID00188519 | N-methyl-N'-[4-(4-imidazolyl)butyl]thiourea | N-METHYL-N'-(4(5)-IMIDAZOLYLBUTYL)THIOUREA | PDSP2_001081 | PDSP1_001097 | BDBM50483128 | Q3268750 | THI

Spécifications et pureté

Moligand™

Conditions de stockage de stockage

Store at 2-8°C,Desiccated

Expédié en

Wet ice

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

AGONIST, ANTAGONIST

Mécanisme d'action

Agonist of H 2 receptor;Antagonist of H 2 receptor;Antagonist of H 3 receptor;Antagonist of H 4 receptor

Propriétés du produit

Ki Data

Histamine H4 Receptor: Ki= 39.81 nM (human); Histamine H3 Receptor: Ki= 70 nM; Histamine H1 Receptor: Ki= 290 μM; Histamine H2 Receptor: Ki= 3.98 μM (human)

Noms et identifiants

Sourires canoniques

CNC(=S)NCCCCC1=CN=CN1

IUPAC Name

1-[4-(1H-imidazol-5-yl)butyl]-3-methylthiourea

InChIKey

HXRBAVXGYZUSED-UHFFFAOYSA-N

INCHI

1S/C9H16N4S/c1-10-9(14)12-5-3-2-4-8-6-11-7-13-8/h6-7H,2-5H2,1H3,(H,11,13)(H2,10,12,14)

Isomères SMILES

CNC(=S)NCCCCC1=CN=CN1

Poids moléculaire

302.35

Reaxy-Rn

24207621

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24207621&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Azoles
      • Subclass Imidazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Azoles
• Subclass: Imidazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Imidazoles
• Alternative Parents: Heteroaromatic compounds Thioureas Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Heteroaromatic compound - Imidazole - Thiourea - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organosulfur compound - Organonitrogen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as imidazoles. These are compounds containing an imidazole ring, which is an aromatic five-member ring with two nitrogen atoms at positions 1 and 3, and three carbon atoms.
• External Descriptors: imidazoles

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

HRH4 Tchem Histamine H4 receptor (4 Activities)

Discover Target: HRH4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH3 Tclin Histamine H3 receptor (4 Activities)

Discover Target: HRH3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH2 Tclin Histamine H2 receptor (1 Activities)

Discover Target: HRH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH2 Tclin Histamine H2 receptor (5428 Activities)

Discover Target: HRH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HRH1 Tclin Histamine H1 receptor (7573 Activities)

Discover Target: HRH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HRH3 Tclin Histamine H3 receptor (10389 Activities)

Discover Target: HRH3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cibles associées (non humaines)

Hrh4 Histamine H4 receptor (388 Activities)

Discover Target: Hrh4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

Discover Target: fba

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Soluble in water (100 mM), and DMSO (100 mM).
• Indice de réfraction: n20D1.59 (Predicted)
• Poids moléculaire: 212.320 g/mol
• XLogP3: 0.400
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 212.11 Da
• Monoisotopic Mass: 212.11 Da
• Topological Polar Surface Area: 84.800 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 174.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Foire aux questions

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 34970-69-9, the molecular formula is C9H16N4S?C2H2O4, and the molecular weight is 302.35 g/mol. InChIKey HXRBAVXGYZUSED-UHFFFAOYSA-N.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.