CA3 (CIL56) - 10mM in DMSO , CAS No.300802-28-2

CAS: 300802-28-2 Cat. No.: C408494 Formule: C₂₃H₂₇N₃O₅S₂ Poids moléculaire: 489.61

GRADE & PURITY 10mM in DMSO

Synonyms

9H-​Fluoren-​9-​one, 2,​7-​bis(1-​piperidinylsulfonyl)​-​, oxime

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Information

CA3 (CIL56) CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-depend
In vitro

CA3 strongly inhibits esophageal adenocarcinoma cell growth in vitro. CA3 can effectively suppress tumor cell proliferation, induce apoptosis, reduce tumor sphere formation, and the population of ALDH1+ cells. CA3 specially inhibits Tead/YAP1 transcriptional activity but shows no inhibitory activity on other transcriptional factors-Super-TOP/Wnt, CBF1/Notch, and AP-1 after cotransfection of their respective individual promoter luciferases in 293T cells. CA3 preferentially inhibits CSC properties enriched in radiation-resistant esophageal adenocarcinoma cells.

In vivo

CA3 exerts strong antitumor activity in xenograft model with no apparent toxicity.
Cell Data

cell lines：

Concentrations：0.5 and 1 μmol/L

Incubation Time：48 hours

Powder Purity:≥99%

Specifications

Synonymes

9H-​Fluoren-​9-​one, 2,​7-​bis(1-​piperidinylsulfonyl)​-​, oxime

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive o

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

ACTIVATOR

Propriétés du produit

• ALogP: 3.058
• hba_count: 5
• Liaison rotative: 4

Noms et identifiants

• Isomères SMILES: C1CCN(CC1)S(=O)(=O)C2=CC3=C(C=C2)C4=C(C3=NO)C=C(C=C4)S(=O)(=O)N5CCCCC5
• Poids moléculaire: 489.61
• Reaxy-Rn: 20605711
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20605711&ln=

Cibles associées (humaines)

PAX8 Tchem Paired box protein Pax-8 (1 Activities)

Discover Target: PAX8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriétés chimiques et physiques

• DMSO (mg/mL) Solubilité maximale: 97
• DMSO (mM) Solubilité maximale: 198.1168685
• Eau (mg/mL) Solubilité maximale: ＜1

Foire aux questions

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 300802-28-2, the molecular formula is C23H27N3O5S2, and the molecular weight is 489.61 g/mol.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.