Cambendazole - Moligand™, ≥98% , CAS No.26097-80-3

CAS: 26097-80-3 Cat. No.: C347195 Formule: C₁₄H₁₄N₄O₂S Poids moléculaire: 302.35 Numéro CE: 247-459-5

GRADE & PURITY Moligand™, ≥98%

Synonyms

079X63S3DU | CAMBENDAZOLE [MART.] | Cambendazole 100 microg/mL in Acetonitrile | MFCD00864552 | QZWHWHNCPFEXLL-UHFFFAOYSA-N | Camdan (TN) | NOE [French] | Equiben | J-690273 | SMR003475014 | DTXSID0046852

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Cambendazole is one of the most effective agents for the research of human strongyloidiasis and.

Specifications

Synonymes

079X63S3DU | CAMBENDAZOLE [MART.] | Cambendazole 100 microg/mL in Acetonitrile | MFCD00864552 | QZWHWHNCPFEXLL-UHFFFAOYSA-N | Camdan (TN) | NOE [French] | Equiben | J-690273 | SMR003475014 | DTXSID0046852

Spécifications et pureté

Moligand™, ≥98%

Conditions de stockage de stockage

Protected from light,Store at -20°C,Argon charged

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Pureté

≥98%

Noms et identifiants

• Pubchem Sid: 528763862
• Sourires canoniques: CC(C)OC(=O)NC1=CC2=C(C=C1)N=C(N2)C3=CSC=N3
• IUPAC Name: propan-2-yl N-[2-(1,3-thiazol-4-yl)-3H-benzimidazol-5-yl]carbamate
• InChIKey: QZWHWHNCPFEXLL-UHFFFAOYSA-N
• INCHI: 1S/C14H14N4O2S/c1-8(2)20-14(19)16-9-3-4-10-11(5-9)18-13(17-10)12-6-21-7-15-12/h3-8H,1-2H3,(H,16,19)(H,17,18)
• Isomères SMILES: CC(C)OC(=O)NC1=CC2=C(C=C1)N=C(N2)C3=CSC=N3
• Poids moléculaire: 302.35
• Reaxy-Rn: 36112466
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=36112466&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Benzimidazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Benzimidazoles
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzimidazoles
• Alternative Parents: Benzenoids Thiazoles Imidazoles Heteroaromatic compounds Propargyl-type 1,3-dipolar organic compounds Carboximidic acids and derivatives Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzimidazole - Benzenoid - Azole - Imidazole - Thiazole - Heteroaromatic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Azacycle - Carboximidic acid derivative - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as benzimidazoles. These are organic compounds containing a benzene ring fused to an imidazole ring (five member ring containing a nitrogen atom, 4 carbon atoms, and two double bonds).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cibles associées (non humaines)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Luciferin 4-monooxygenase (66902 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mécanismes d'action

Propriétés chimiques et physiques

• Sensibilité: 对光线敏感
• Poids moléculaire: 302.350 g/mol
• XLogP3: 2.900
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 302.084 Da
• Monoisotopic Mass: 302.084 Da
• Topological Polar Surface Area: 108.000 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 382.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Références

1. Zhechang Chen, Caijie Yuan, Yaxin Ye, Bitao Lu, Enling Hu, Fei Lu, Kun Yu, Ruiqi Xie, Guangqian Lan.  (2023)  Dual-targeting fucoidan-based microvesicle for arterial thrombolysis and re-occlusion inhibition.  CARBOHYDRATE POLYMERS,      [PMID:38220339] [10.1016/j.carbpol.2023.121703]

2. Song Jianwen, Kang Xiaoying, Wang Lu, Ding Dan, Kong Deling, Li Wen, Qi Ji.  (2023)  Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles.  Nature Communications,  14  (1): (1-19).  [PMID:37898604] [10.1038/s41467-023-42691-8]

3. Weiwei Zhang, Yuguo Deng, Jinhao Zhao, Tao Zhang, Xiang Zhang, Wenping Song, Lin Wang, Tianlong Li.  (2023)  Amoeba-Inspired Magnetic Venom Microrobots.  Small,  19  (23): (2207360).  [PMID:36869412] [10.1002/smll.202207360]

4. Mei Jian feng, Cai Shao fen, Yi Yu, Wang Xu dong, Ying Guo qing.  (2023)  Study of the fibrinolytic activity of serrapeptase and its in vitro thrombolytic effects.  Brazilian Journal of Pharmaceutical Sciences,      [PMID:] [10.1590/s2175-97902022e201004]

5. Songzhi Xie, Shang Li, Wenxiong Cao, Chuanfei Mo, Zhanlin Zhang, Kun Huang, Xiaohong Li.  (2022)  Bacteria-Templated and Dual Enzyme-Powered Microcapsule Motors To Promote Thrombus Penetration and Thrombolytic Efficacy.  ACS Applied Materials & Interfaces,      [PMID:35948498] [10.1021/acsami.2c11213]

6. Dongya Wang, Qianqian Zhao, Jingcan Qin, Yuanyuan Guo, Chuan Zhang, Yuehua Li.  (2022)  Urokinase loaded black phosphorus nanosheets for sequential thrombolysis and reactive oxygen species scavenging in ischemic stroke treatment.  Biomaterials Science,  10  (16): (4656-4666).  [PMID:35801526] [10.1039/D2BM00746K]

7. Songzhi Xie, Chuanfei Mo, Wenxiong Cao, Shuang Xie, Shang Li, Zhanlin Zhang, Xiaohong Li.  (2022)  Bacteria-propelled microtubular motors for efficient penetration and targeting delivery of thrombolytic agents.  Acta Biomaterialia,      [PMID:35158079] [10.1016/j.actbio.2022.02.008]