Capmatinib (INCB28060) - Moligand™, 2mM in DMSO , Hepatocyte growth factor receptor inhibitor, CAS No.1029712-80-8, Hepatocyte growth factor receptor inhibitor

CAS: 1029712-80-8 Cat. No.: C408636 Formule: C₂₃H₁₇FN₆O Poids moléculaire: 412.42 Numéro CE: 813-241-9

GRADE & PURITY Moligand™, 2mM in DMSO

Synonyms

INC280, NVP-INC280 | 2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Information

Capmatinib (INCB28060) Capmatinib (INCB28060, INC280, NVP-INC280) is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. Capmatinib (INCB28060) inhibits Wnt/β-catenin a
In vitro

INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. INCB28060 inhibits human c-MET phosphorylation and c-MET-mediated signaling in cancer cells. INCB28060 inhibits c-MET-dependent cell proliferation and survival, and prevents anchorage-independent cancer cell growth and cell migration.

In vivo

INCB28060 shows strong antitumor activity in c-MET-dependent mouse tumor models, even oral treatment of 0.03 mg/kg INCB28060 causes approximately 50% inhibition of c-MET-phosphorylation. Dose-dependent inhibition of tumor growth is observed in tumor-bearing mice.
Cell Data

cell lines：

Concentrations：0.24, 1, 4, 16, 63 nM

Incubation Time：24 hours

Powder Purity:≥99%

Specifications

Synonymes

INC280, NVP-INC280 | 2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide

Spécifications et pureté

Moligand™, 2mM in DMSO

Mécanismes biochimiques et physiologiques

Capmatinib (INCB28060, INC280, NVP-INC280) is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. Capmatinib (INCB28060) inhibits Wnt/β-catenin and EMT signaling pathways

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

INHIBITOR

Mécanisme d'action

Hepatocyte growth factor receptor inhibitor

Propriétés du produit

• ALogP: 2.9

Noms et identifiants

• Isomères SMILES: CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F
• Poids moléculaire: 412.42
• Reaxy-Rn: 18352802
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18352802&ln=

Cibles associées (humaines)

MET Tclin Hepatocyte growth factor receptor (4 Activities)

Discover Target: MET

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)