(+)-Catechin Hydrate - ≥95%(HPLC) , CAS No.225937-10-0

CAS: 225937-10-0 Cat. No.: C107690 Molecular Weight: 290.27 (as Anhydrous) Beilstein Registry Number: 3595244 EC Number: 684-232-3
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GRADE & PURITY ≥95%(HPLC)
Synonyms
2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, monohydrate, (2R,3S)- | (+/-)-Catechin hydrate, primary pharmaceutical reference standard | (2R,3S)-2-(3,4-Dihydroxyphenyl)-chroman-3,5,7-triol hydrate | (2R,3S)-2-(3,4-Dihydroxyphenyl)chr
Storage
Store at 2-8°C,Argon charged
Shipped In
Wet ice
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Size
Status
Price
Qty
1g
C107690-1g
2
$17.90
5g
C107690-5g
2
$44.90
25g
C107690-25g
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$199.90
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Why this grade

≥95%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 24 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

(+)-Catechin monohydrate is an antioxidant flavonoid that is a free radical scavenger. Research shows that it is relatively nontoxic to cells at high doses. (+)-Catechin can stop ultraviolet B induced human keratinocyte death through the inhibition of JNK phosphorylation. Literature indicates that it may have Ca2+ antagonistic activity. (+)-Catechin monohydrate is an inhibitor of Cox-1.
An antioxidant flavonoid that is a free radical scavenger

Specifications

Synonyms
2H-1-Benzopyran-3, 5, 7-triol, 2-(3, 4-dihydroxyphenyl)-3, 4-dihydro-, monohydrate, (2R, 3S)- | (+/-)-Catechin hydrate, primary pharmaceutical reference standard | (2R, 3S)-2-(3, 4-Dihydroxyphenyl)-chroman-3, 5, 7-triol hydrate | (2R, 3S)-2-(3, 4-Dihydroxyphenyl)chr
Specifications & Purity
≥95%(HPLC)
Biochemical and Physiological Mechanisms
An antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological systems. For example, at physiological pH catechin suppressed DNA strand breaks by hydroxyl radicals. It has also been s
Storage
Store at 2-8°C, Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥95%(HPLC)
Names and Identifiers
Pubchem Sid504756641
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504756641
Canonical SmilesC1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O.O
IUPAC Name(2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol;hydrate
InChIKeyOFUMQWOJBVNKLR-NQQJLSKUSA-N
INCHI1S/C15H14O6.H2O/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7;/h1-5,13,15-20H,6H2;1H2/t13-,15+;/m0./s1
Isomeric SMILES C1[C@@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O.O
WGK Germany 3
RTECS DJ3450000
Alternate CAS 154-23-4
Molecular Weight 290.27 (as Anhydrous)
Beilstein 3595244
Reaxy-Rn 31285846
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31285846&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassPhenylpropanoids and polyketides
ClassFlavonoids
SubclassFlavans
Intermediate Tree Nodes Flavan-3-ols
Direct ParentCatechins
Alternative Parents 3'-hydroxyflavonoids  3-hydroxyflavonoids  4'-hydroxyflavonoids  5-hydroxyflavonoids  7-hydroxyflavonoids  1-benzopyrans  Catechols  1-hydroxy-2-unsubstituted benzenoids  1-hydroxy-4-unsubstituted benzenoids  Alkyl aryl ethers  Benzene and substituted derivatives  Secondary alcohols  Oxacyclic compounds  Polyols  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Catechin - Hydroxyflavonoid - 7-hydroxyflavonoid - 5-hydroxyflavonoid - 4'-hydroxyflavonoid - 3-hydroxyflavonoid - 3'-hydroxyflavonoid - 1-benzopyran - Chromane - Benzopyran - Catechol - Alkyl aryl ether - Phenol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Benzenoid - Monocyclic benzene moiety - Secondary alcohol - Oxacycle - Organoheterocyclic compound - Polyol - Ether - Alcohol - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as catechins. These are compounds containing a catechin moiety, which is a 3,4-dihydro-2-chromene-3,5.7-tiol.
External Descriptors hydrate
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLB Tchem DNA polymerase beta (23632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALPG Tchem Alkaline phosphatase placental-like (1197 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALPL Tchem Alkaline phosphatase, tissue-nonspecific isozyme (1551 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Iap Intestinal alkaline phosphatase (419 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
dnaB Replicative DNA helicase (15 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Large T antigen (1457 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
recA Protein RecA (2211 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

14 results found

Lot NumberCertificate TypeDateItem
F2622207Certificate of AnalysisJun 04, 2026 C107690
F2622209Certificate of AnalysisJun 04, 2026 C107690
F2213095Certificate of AnalysisDec 12, 2025 C107690
F2213098Certificate of AnalysisDec 12, 2025 C107690
C2604352Certificate of AnalysisDec 04, 2025 C107690
C2607017Certificate of AnalysisDec 04, 2025 C107690
K2520071Certificate of AnalysisNov 25, 2025 C107690
B2210034Certificate of AnalysisAug 11, 2025 C107690
B2210035Certificate of AnalysisAug 11, 2025 C107690
E2516251Certificate of AnalysisApr 12, 2024 C107690
E2516481Certificate of AnalysisApr 12, 2024 C107690
C2126033Certificate of AnalysisJan 12, 2023 C107690
C2126034Certificate of AnalysisJan 12, 2023 C107690
J2026190Certificate of AnalysisAug 15, 2022 C107690

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Chemical and Physical Properties
SensitivityAir sensitive ;Heat sensitive
Melt Point(°C)96°C(lit.)
Molecular Weight308.280 g/mol
XLogP3
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count7
Rotatable Bond Count1
Exact Mass308.09 Da
Monoisotopic Mass308.09 Da
Topological Polar Surface Area111.000 Ų
Heavy Atom Count22
Formal Charge0
Complexity364.000
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count2
Citations of This Product
References
1. Zijian Liang, Pangzhen Zhang, Wen Ma, Xin-An Zeng, Zhongxiang Fang.  (2023)  Physicochemical properties, antioxidant activities and comprehensive phenolic profiles of tea-macerated Chardonnay wine and model wine.  FOOD CHEMISTRY,      [PMID:37862991] [10.1016/j.foodchem.2023.137748]
2. Tong Jiang, Hong Wang, Peihua Xu, Yifan Yao, Yilong Ma, Zhaojun Wei, Xiangli Niu, Yafang Shang, Dong Zhao.  (2023)  Effect of grape seed proanthocyanidin on the structural and physicochemical properties of bread during bread fermentation stage.  Current Research in Food Science,      [PMID:37600464] [10.1016/j.crfs.2023.100559]
3. Mao-Ling Luo, Hua Chen, Guo-Ying Chen, Shengpeng Wang, Yitao Wang, Feng-Qing Yang.  (2023)  Preparation of Alcohol Dehydrogenase–Zinc Phosphate Hybrid Nanoflowers through Biomimetic Mineralization and Its Application in the Inhibitor Screening.  MOLECULES,  28  (14): (5429).  [PMID:37513303] [10.3390/molecules28145429]
4. Chengxiang Chu, Xianfeng Wang, Yuanyi Deng, Yi Ma, Chengyue Zou, Mei Yang, Huibo Luo, Danqun Huo, Changjun Hou.  (2023)  Discrimination of Chinese green tea according to tea polyphenols using fluorescence sensor array based on Tb (III) and Eu (III) doped Zr (IV) metal–organic frameworks.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:36736046] [10.1016/j.saa.2023.122380]
5. Shuai Zhang, Qin Ma, Lihong Dong, Xuchao Jia, Lei Liu, Fei Huang, Guang Liu, Zhida Sun, Jianwei Chi, Mingwei Zhang, Ruifen Zhang.  (2022)  Phenolic profiles and bioactivities of different milling fractions of rice bran from black rice.  FOOD CHEMISTRY,      [PMID:35042109] [10.1016/j.foodchem.2021.132035]
6. Yirong Xia, Xintong Wang, Hechen Sun, Ximing Huang.  (2021)  Proton-coupled electron transfer of catechin in tea wine: the enhanced mechanism of anti-oxidative capacity.  RSC Advances,  11  (63): (39985-39993).  [PMID:35494161] [10.1039/D1RA07769D]
7. Murtaza Ali, Jun-Hu Cheng, Da-Wen Sun.  (2020)  Effects of dielectric barrier discharge cold plasma treatments on degradation of anilazine fungicide and quality of tomato (Lycopersicon esculentum Mill) juice.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  56  (1): (69-75).  [PMID:] [10.1111/ijfs.14600]
8. Mengting Wang, Jinyuan Shi, Lei Wang, Yaqin Hu, Xingqian Ye, Donghong Liu, Jianchu Chen.  (2018)  Inhibitory kinetics and mechanism of flavonoids from lotus (Nelumbo nucifera Gaertn.) leaf against pancreatic α-amylase.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:30195612] [10.1016/j.ijbiomac.2018.09.035]
9. Juan Xu, Hongpo Zhou, Kun Li, Jinju Ma, Wenwen Zhang, Lanxiang Liu, Yanlin Sun, Hong Zhang, Kai Li.  (2018)  Multi-scale pectin/polyphenol beads for non-fouling fluorescence tracking on soft matter under water.  CARBOHYDRATE POLYMERS,      [PMID:30143119] [10.1016/j.carbpol.2018.07.021]
10. Rana Muhammad Aadil, Xin-An Zeng, Zhong Han, Amna Sahar, Anees Ahmed Khalil, Ubaid Ur Rahman, Muneeb Khan, Tariq Mehmood.  (2017)  Combined effects of pulsed electric field and ultrasound on bioactive compounds and microbial quality of grapefruit juice.  JOURNAL OF FOOD PROCESSING AND PRESERVATION,  42  (2): (e13507).  [PMID:] [10.1111/jfpp.13507]
11. Dongwei Wei, Weizhi Huo, Guangmeng Li, Qiuling Xie, Yanbin Jiang.  (2017)  The combined effects of lysozyme and ascorbic acid on microstructure and properties of zein-based films.  CHINESE JOURNAL OF CHEMICAL ENGINEERING,      [PMID:] [10.1016/j.cjche.2017.07.005]
12. Lite Yang, Bingjie Xu, Huili Ye, Faqiong Zhao, Baizhao Zeng.  (2017)  A novel quercetin electrochemical sensor based on molecularly imprinted poly(para-aminobenzoic acid) on 3D Pd nanoparticles-porous graphene-carbon nanotubes composite.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2017.04.006]
13. Lele Zhang, Minglei Yang, Junlan Gao, Shan Jin, Zhengyan Wu, Lifang Wu, Xin Zhang.  (2015)  Seasonal variation and gender pattern of phenolic and flavonoid contents in Pistacia chinensis Bunge inflorescences and leaves.  JOURNAL OF PLANT PHYSIOLOGY,      [PMID:26717010] [10.1016/j.jplph.2015.11.014]
14. Rana Muhammad Aadil, Xin-An Zeng, Amjad Ali, Feng Zeng, Muhammad Adil Farooq, Zhong Han, Saud Khalid, Saqib Jabbar.  (2015)  Influence of different pulsed electric field strengths on the quality of the grapefruit juice.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  50  (10): (2290-2296).  [PMID:] [10.1111/ijfs.12891]
15. Rana Muhammad Aadil, Xin-An Zeng, Man-Sheng Wang, Zhi-Wei Liu, Zhong Han, Zhi-Hong Zhang, Jing Hong, Saqib Jabbar.  (2015)  A potential of ultrasound on minerals, micro-organisms, phenolic compounds and colouring pigments of grapefruit juice.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  50  (5): (1144-1150).  [PMID:] [10.1111/ijfs.12767]
16. Rana Muhammad Aadil, Xin-An Zeng, Zhi-Hong Zhang, Man-Sheng Wang, Zhong Han, Hong Jing, Saqib Jabbar.  (2015)  Thermosonication: a potential technique that influences the quality of grapefruit juice.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  50  (5): (1275-1282).  [PMID:] [10.1111/ijfs.12766]
17. Yurong Ma, Huihua Huang.  (2014)  Characterisation and comparison of phenols, flavonoids and isoflavones of soymilk and their correlations with antioxidant activity.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  49  (10): (2290-2298).  [PMID:] [10.1111/ijfs.12545]
18. Mengying He, Ting Wu, Siyi Pan, Xiaoyun Xu.  (2014)  Antimicrobial mechanism of flavonoids against Escherichia coli ATCC 25922 by model membrane study.  APPLIED SURFACE SCIENCE,      [PMID:] [10.1016/j.apsusc.2014.03.125]
19. Huijie Zhang, Mingqin Kang, Hanqi Zhang, Yong Yu.  (2013)  Matrix solid phase dispersion extraction for determination of flavonoids in the flower of Chrysanthemum morifolium Ramat. by capillary zone electrophoresis.  Analytical Methods,  (3): (766-773).  [PMID:] [10.1039/C3AY41293H]
20. Obafemi Ibitayo Obajemihi, Jun-Hu Cheng, Da-Wen Sun.  (2024)  Enhancing Moisture Transfer and Quality Attributes of Tomato Slices Through Synergistic Cold Plasma and Osmodehydration Pretreatments During Infrared-Assisted Pulsed Vacuum Drying.  JOURNAL OF FOOD ENGINEERING,      [PMID:] [10.1016/j.jfoodeng.2024.112335]
21. Obafemi Ibitayo Obajemihi, Jun-Hu Cheng, Da-Wen Sun.  (2024)  Novel cold plasma functionalized water pretreatment for improving drying performance and physicochemical properties of tomato (Solanum lycopersicum L.) fruits during infrared-accelerated pulsed vacuum drying.  JOURNAL OF FOOD ENGINEERING,      [PMID:] [10.1016/j.jfoodeng.2024.112050]
22. Liang Zijian, Zhang Pangzhen, Ma Wen, Zeng Xin-An, Fang Zhongxiang.  (2024)  Quality attributes of black tea-flavored Chardonnay wine processed by ultrasound.  Food Production Processing and Nutrition,  (1): (1-15).  [PMID:] [10.1186/s43014-024-00239-3]
23. Guipeng Jia, Tingting Ouyang, Yanyan Wang, Ximing Huang.  (2025)  Investigating the synergistic antioxidant behavior of catechin and copper ion in tea: The mechanism of coordination-activation effect.  Food Chemistry-X,      [PMID:40241704] [10.1016/j.fochx.2025.102440]
24. Guipeng Jia, Ning Deng, Tingting Ouyang, Yanyan Wang, Ximing Huang.  (2025)  Iron(III) suppresses catechin antioxidant activity in tea: Spectroscopic and electrochemical support for a coordination–passivation–oxidation mechanism.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.107853]
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