CDK12-IN-3 - 10mM in DMSO , CAS No.2220184-50-7

CAS: 2220184-50-7 Cat. No.: C655226 Molecular Weight: 470.52

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

CDK12-IN-3 is a potent and selective CDK12 inhibitor with an IC 50 of 491 nM in enzymatic assay.

In Vitro

CDK12-IN-3 is a highly selective CDK12 inhibitor. CDK12-IN-3 (0.1 μM) shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II as well as growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells.. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:CDK12 491 nM (IC 50 )

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

CDK12-IN-3 is a potent and selective CDK12 inhibitor with an IC 50 of 491 nM in enzymatic assay.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CC(C)N1C=NC2=C(N=C(N=C21)N3CCCC[C@H]3CCO)NCC4=NC5=C(N4)C=CC(=C5F)F
• Molecular Weight: 470.52
• Reaxy-Rn: 62165380
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=62165380&ln=