CDK8-IN-1 - 10mM in DMSO , CAS No.1629633-48-2

CAS: 1629633-48-2 Cat. No.: C655866 Formule: C₁₁H₈F₃N₃O Poids moléculaire: 255.20 PubChem CID: 86274989

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC 50 of 3 nM.

In Vivo

CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The t max is 0.25 h by PO. The mean values of C max are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:CDK8 3 nM (IC 50 )

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC 50 of 3 nM.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Noms et identifiants

• Isomères SMILES: C1=CN=CC=C1C2=CNC(=C2C(F)(F)F)C(=O)N
• PubChem CID: 86274989
• Poids moléculaire: 255.20