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CE-245677 - 10mM in DMSO , CAS No.717899-97-3
AVAILABLE TO ORDER
GRADE & PURITY 10mM in DMSO
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Why this grade
10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC 50 s of 4.7 and 1 nM.
In Vitro
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC 50 of 4.7 and 1 nM, and displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
CE-245677 shows good oral absorption in in vivo rat PK studies (F=80%) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:TrkA Tie2 4.7 nM (IC 50 )
Specifications
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC 50 s of 4.7 and 1 nM.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Names and Identifiers
| Isomeric SMILES | CC(C)N1C=C(C2=C(N=CN=C21)N)C(=O)C3=CC(=C(C=C3)OC)NC(=O)NC4=C(C=C(C=C4)Cl)Cl |
|---|---|
| Alternate CAS | 717899-97-3 |
| PubChem CID | 16048643 |
| Molecular Weight | 513.4 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
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