CHIKV-IN-2 - 10mM in DMSO , CAS No.2361289-44-1

CAS: 2361289-44-1 Cat. No.: C656265 Formule: C₂₃H₂₆N₂O₂ Poids moléculaire: 362.46 PubChem CID: 142616713

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV) , with excellent cellular antiviral activity ( EC 90 =270 nM) and improved liver microsomal stability. CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH) , which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools

In Vitro

CHIKV-IN-2 (compound 8q) is a potent pan-alphavirus inhibitor, with EC 90 s of 0.85-2.5 μM for CHIKV clinical isolates and attenuated vaccine strains. CHIKV-IN-2 is active against alphavirus VEEV (EC 90 =0.40 μM) as well as flaviviruses such as West Nile Virus (WNV, EC 90 =0.20 μM) and Dengue Virus Strain-2 (DENV-2, EC 90 =0.60 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CHIKV-IN-2 (compound 8q) (80 mg/kg; i.p. twice a day for 3 days) significantly decreases infectious CHIKV dissemination to other tissues of mice . CHIKV-IN-2 (40 mg/kg; p.o., i.p., s.c.) exhibits moderate bioavailability (F=41%, 43%, 4%), terminal elimination half-life (t 1/2 =9.9, 18.5, 18.6 h) and C max (642, 858, 90 ng/mL) in mice . CHIKV-IN-2 (1 mg/kg; i.v.) exhibits terminal elimination half-life (t 1/2 = 2.02 h) and AUC (497 h•ng/mL) in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female and male C57BL/6 mice Dosage: 80 mg/kg Administration: I.p. twice a day for 3 days Result: Failed to inhibit virus loads at the site of infection. Decreased virus dissemination to other tissues. Animal Model: Male C57BL/6 mice were challenged with CHIKV in the right footpad Dosage: 1 mg/kg for i.v. and 40 mg/kg for p.o., i.p., s.c. (Pharmacokinetic Analysis) Administration: I.v., p.o., i.p., s.c. Result: I.v.: t 1/2 = 2.02 h; AUC=497 h•ng/mL. P.o.: F=41%; t 1/2 =9.9 h; C max =642 ng/mL. I.p.: F=43%; t 1/2 =18.5 h; C max =858 ng/mL. S.c.: F=4%; t 1/2 =18.6 h; C max =90 ng/mL.

IC50& Target:EC90: 270 nM (Chikungunya virus), Dihydroorotate Dehydrogenase

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV) , with excellent cellular antiviral activity ( EC 90 =270 nM) and improved liver microsomal stability. CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydro

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Noms et identifiants

• Isomères SMILES: CC(C)(C#N)C1=CC=C(C=C1)NC(=O)C2=C(C=C3CCCCCC3=C2)OC
• PubChem CID: 142616713
• Poids moléculaire: 362.46

Foire aux questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2361289-44-1, the molecular formula is C23H26N2O2, and the molecular weight is 362.46 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.