Chlorhydrate de protriptyline - ≥98% , Norepinephrine transporter inhibitor, CAS No.1225-55-4, Norepinephrine transporter inhibitor

CAS: 1225-55-4 Cat. No.: P137447 Formule: C₁₉H₂₂ClN Poids moléculaire: 299.838 Numéro CE: 214-956-3 PubChem CID: 6603149

QUALITÉ & PURETÉ ≥98%

Synonyms

Protriptyline hydrochloride (USP)|PROTRIPTYLINE HYDROCHLORIDE [USP-RS]|Protriptyline hydrochloride (USAN:USP)|1,3-benzene diacetonitrile|5H-Dibenzo[a, N-methyl-, hydrochloride|Opera_ID_812|Protriptyline.HCl|Concordin|Protriptyline hydrochloride [USAN:USP]|N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)propan-1-amine;hydrochloride|Vivactil (TN)|PROTRIPTYLINE HYDROCHLORIDE (USP-RS)|Protriptyline hydrochloride|N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine hydrochloride|5-(3-Methylaminopropyl)-5H-dibenzo(a,d)cycloheptene hydrochloride|4,4-BIS(2-SULFONATOSTYRYL)BIPHENYLDISODIUMSALT|5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-, hydrochloride|Homopiperidinic Acid Hydrochloride|PROTRIPTYLINE HYDROCHLORIDE [WHO-DD]|Normethyl EX4442|PROTRIPTYLINE HYDROCHLORIDE [VANDF]|Pharmakon1600-01505984|PROTRIPTYLINE HYDROCHLORIDE (MART.)|1,3-bisbromomethylbenzene|N-methyl-3-(2-tricyclo[9.4.0.0^{3,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)propan-1-amine;hydrochloride|PROTRIPTYLINE HYDROCHLORIDE [ORANGE BOOK]|Protriptyline hydrochloride [USAN]|Triptil (VAN)|5H-Dibenzo(a,d)cycloheptene-5-propylamine, N-methyl-, hydrochloride|MK-240 (VAN)|PROTRIPTYLINE HYDROCHLORIDE [USP MONOGRAPH]|PROTRIPTYLINE HYDROCHLORIDE [MART.]|Hydrochloride, Protriptyline|N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine hydrochloride|PROTRIPTYLINE HYDROCHLORIDE [MI]|Protriptyline-d3 Hydrochloride|Triptyl|N-Methyl-5H-dibenzo(a,d)cycloheptene-5-propylamine hydrochloride|Maximed|MK-240|3-(5H-dibenzo(a,d)(7)annulen-5-yl)-N-methylpropan-1-aminium chloride|5-[3-(Methylamino)propyl]-5H-dibenzo[a,d]cycloheptene hydrochloride|Protriptyline (hydrochloride)|Protriptyline HCl

Storage

A l'abri de la lumière,A conserver à -20°C

Shipped In

Glacière + blocs de glace

Vue d’ensemble

Le chlorhydrate de protriptyline est un antidépresseur tricyclique (ATC), en particulier une amine secondaire, destiné au traitement de la dépression et du TDAH. Unique parmi les ATC, la protriptyline a tendance à être énergisante plutôt que sédative, utilisée pour la narcolepsie afin d'obtenir un effet favorisant l'éveil.

Spécifications

Synonymes

Protriptyline hydrochloride (USP) | PROTRIPTYLINE HYDROCHLORIDE [USP-RS] | Protriptyline hydrochloride (USAN:USP) | 1,3-benzene diacetonitrile | 5H-Dibenzo[a, N-methyl-, hydrochloride | Opera_ID_812 | Protriptyline.HCl | Concordin | Protriptyline hydrochloride [USAN:USP] | N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-he Afficher plus

Spécifications et pureté

≥98%

Conditions de stockage de stockage

A l'abri de la lumière,A conserver à -20°C

Expédié en

Glacière + blocs de glace

Type d'action

INHIBITOR

Mécanisme d'action

Norepinephrine transporter inhibitor

Pureté

≥98%

Noms et identifiants

Pubchem Sid

528773739

Sourires canoniques

CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13.Cl

IUPAC Name

N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)propan-1-amine;hydrochloride

InChIKey

OGQDIIKRQRZXJH-UHFFFAOYSA-N

INCHI

1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;1H

Isomères SMILES

CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13.Cl

WGK Allemagne

3

RTECS

HP1400000

PubChem CID

6603149

Poids moléculaire

299.838

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Dibenzocycloheptenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Dibenzocycloheptenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Dibenzocycloheptenes
• Alternative Parents: Aralkylamines Dialkylamines Organopnictogen compounds Organic chloride salts Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Dibenzocycloheptene - Aralkylamine - Secondary amine - Secondary aliphatic amine - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organic chloride salt - Organic salt - Organonitrogen compound - Amine - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as dibenzocycloheptenes. These are compounds containing a dibenzocycloheptene moiety, which consists of two benzene rings connected by a cycloheptene ring.
• External Descriptors: hydrochloride

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

SLC6A2 Tclin Sodium-dependent noradrenaline transporter (0 Activities)

Discover Target: SLC6A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

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HEK293 (82097 Activities)

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HepG2 (196354 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

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KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

Discover Target: KDM4E

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SMN1 Tchem Survival motor neuron protein (34246 Activities)

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GMNN Tbio Geminin (128009 Activities)

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PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

Discover Target: PMP22

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IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

Discover Target: IDH1

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MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

Discover Target: MEN1

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Cibles associées (non humaines)

Plasmodium falciparum (966862 Activities)

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Impa1 Inositol monophosphatase 1 (16203 Activities)

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FTL Ferritin light chain (43324 Activities)

Discover Target: FTL

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nfo Endonuclease 4 (425 Activities)

Discover Target: nfo

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: solubility H2O: 50 mg/mL
• Sensibilité: Light sensitive；Moisture sensitive
• Poids moléculaire: 299.800 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 299.144 Da
• Monoisotopic Mass: 299.144 Da
• Topological Polar Surface Area: 12.000 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 296.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3