CHR-6494 - ≥98% , CAS No.1333377-65-3

CAS: 1333377-65-3 Cat. No.: C124894 Formule: C₁₆H₁₆N₆ Poids moléculaire: 292.34

GRADE & PURITY ≥98%

Synonyms

FT-0734501 | NCGC00370724-05 | 1333377-65-3 | CHR6494 | CHR-6494 | HY-15217 | BDBM50587785 | DTXSID90742629 | AKOS025149446 | F84874 | A899134 | 3-(1H-Indazol-5-yl)-N-propylimidazo-[1,2-b]pyridazin-6-amine | 3-(1H-indazol-5-yl)-N-propylimidazo[1,2-b]pyrid

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonymes

FT-0734501 | NCGC00370724-05 | 1333377-65-3 | CHR6494 | CHR-6494 | HY-15217 | BDBM50587785 | DTXSID90742629 | AKOS025149446 | F84874 | A899134 | 3-(1H-Indazol-5-yl)-N-propylimidazo-[1,2-b]pyridazin-6-amine | 3-(1H-indazol-5-yl)-N-propylimidazo[1,2-b]pyrid

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

CHR-6494 is a potent and selective Haspin (Haploid Germ Cell-Specific Nuclear Protein Kinase) inhibitor that blocks H3T3ph phosphorylation. CHR-6494 causes cell cycle arrest in G2/M and subsequent apoptosis. CHR-6494 causes an abnormal duplication of cent

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Pureté

≥98%

Noms et identifiants

• Sourires canoniques: CCCNC1=NN2C(=NC=C2C3=CC4=C(C=C3)NN=C4)C=C1
• IUPAC Name: 3-(1H-indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine
• InChIKey: CZZCAOGIEGXMBZ-UHFFFAOYSA-N
• INCHI: 1S/C16H16N6/c1-2-7-17-15-5-6-16-18-10-14(22(16)21-15)11-3-4-13-12(8-11)9-19-20-13/h3-6,8-10H,2,7H2,1H3,(H,17,21)(H,19,20)
• Isomères SMILES: CCCNC1=NN2C(=NC=C2C3=CC4=C(C=C3)NN=C4)C=C1
• CAS alternatif: 1458630-17-5 （TFA salt）
• Poids moléculaire: 292.34
• Reaxy-Rn: 29788281
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29788281&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Benzopyrazoles
      • Subclass Indazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Benzopyrazoles
• Subclass: Indazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Indazoles
• Alternative Parents: Aminopyridazines N-substituted imidazoles Imidolactams Benzenoids Pyrazoles Heteroaromatic compounds Azacyclic compounds Hydrocarbon derivatives Amines
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzopyrazole - Indazole - Aminopyridazine - N-substituted imidazole - Pyridazine - Benzenoid - Imidolactam - Pyrazole - Heteroaromatic compound - Imidazole - Azole - Azacycle - Organonitrogen compound - Amine - Hydrocarbon derivative - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as indazoles. These are compounds containing an indazole, which is structurally characterized by a pyrazole fused to a benzene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)

Discover Target: ABL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)

Discover Target: GSK3B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PIM1 Tchem Serine/threonine-protein kinase PIM1 (9629 Activities)

Discover Target: PIM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

JAK3 Tclin Tyrosine-protein kinase JAK3 (8349 Activities)

Discover Target: JAK3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSNK1E Tclin Casein kinase I epsilon (1412 Activities)

Discover Target: CSNK1E

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HASPIN Tchem Serine/threonine-protein kinase haspin (906 Activities)

Discover Target: HASPIN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CDK5 Tchem Cyclin-dependent kinase 5/CDK5 activator 1 (3697 Activities)

Discover Target: CDK5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cibles associées (non humaines)

Dyrk1a Dual specificity tyrosine-phosphorylation-regulated kinase 1A (1629 Activities)

Discover Target: Dyrk1a

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Clk1 Dual specificity protein kinase CLK1 (404 Activities)

Discover Target: Clk1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: DMSO
• Poids moléculaire: 292.340 g/mol
• XLogP3: 2.800
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 292.144 Da
• Monoisotopic Mass: 292.144 Da
• Topological Polar Surface Area: 70.900 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 378.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1