Clofibrate - Moligand™, 10mM in DMSO , Peroxisome proliferator-activated receptor alpha agonist, CAS No.637-07-0, Peroxisome proliferator-activated receptor alpha agonist

CAS: 637-07-0 Cat. No.: C408591 Molecular Weight: 242.7 Beilstein Registry Number: 1913459 EC Number: 211-277-4

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Clofibrate (Atromid-S), a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Clofibrate (Atromid-S), a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia. Clofibrate increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipop

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Peroxisome proliferator-activated receptor alpha agonist

Product Properties

• ALogP: 3.3

Names and Identifiers

• Isomeric SMILES: CCOC(=O)C(C)(C)OC1=CC=C(C=C1)Cl
• WGK Germany: 3
• RTECS: UE9480000
• UN Number: 3082
• Molecular Weight: 242.7
• Beilstein: 1913459
• Reaxy-Rn: 1913459
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1913459&ln=

Associated Targets(Human)

PPARA Tclin Peroxisome proliferator-activated receptor alpha (1 Activities)

Discover Target: PPARA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Refractive Index: 1.503
• Flash Point(°F): 235.4 °F - closed cup
• Flash Point(°C): 113 °C - closed cup
• Boil Point(°C): 150 °C

References

1. Cancan Duan, Weina Cheng, Qihong Chen, Xiaofei Li, Jianyong Zhang.  (2021)  Pharmacokinetics and tissue distribution of cantharidin after oral administration of aqueous extracts from Mylabris in rats.  BIOMEDICAL CHROMATOGRAPHY,  35  (10): (e5172).  [PMID:33982312] [10.1002/bmc.5172]

2. Ruijie Xie, Kaiheng Guo, Zhimin Ao, Ziyi Suo, Haibao Huang, DYC Leung.  (2023)  Surface-bound radicals generated from cobalt single-atom catalyst: Mechanism of boosting Fenton-like reactions.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.141920]

3. Hui Sun, Jianzhong Du.  (2018)  Plasmonic vesicles with tailored collective properties.  Nanoscale,  10  (36): (17354-17361).  [PMID:30198031] [10.1039/C8NR04820G]