Clomifene citrate - 10mM in DMSO , CAS No.50-41-9

CAS: 50-41-9 Cat. No.: C409201 Molecular Weight: 598.08 EC Number: 200-035-3

GRADE & PURITY 10mM in DMSO

Synonyms

NSC 35770 | 2-​[4-​(2-​chloro-​1,​2-​diphenylethenyl)​phenoxy]​-​N,​N-​diethyl-​ethanamine, 2-​hydroxy-​1,​2,​3-​propanetricarboxylat​e (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Clomifene Citrate (NSC 35770) is a selectiveestrogen receptormodulator, used in the treatment of ovulation induction.
In vitro

Clomifene competes with [3H]-QNB and [3H]-nitrendipine for their\xa0binding\xa0to the receptor in the membrane fractions from the urinary bladder and myometrium. Clomifene inhibits\xa0estrogen receptors\xa0in the\xa0hypothalamus, inhibiting\xa0negative feedback\xa0of estrogen on\xa0gonadotropinrelease, leading to up-regulation of the\xa0hypothalamic–pituitary–gonadal axis. Clomifene is a mixture of two\xa0geometric isomers, enclomifene (E-clomifene) and zuclomifene (Z-clomifene).\xa0

In vivo

Clomiphene\xa0citrate\xa0treatment significantly increases the chance of homosexuality and effeminized\xa0behavior in male mice.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyms

NSC 35770 | 2-​[4-​(2-​chloro-​1, ​2-​diphenylethenyl)​phenoxy]​-​N, ​N-​diethyl-​ethanamine, 2-​hydroxy-​1, ​2, ​3-​propanetricarboxylat​e (1:1)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Clomifene Citrate (NSC 35770) is a selective estrogen receptor modulator, used in the treatment of ovulation induction.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: CCN(CC)CCOC1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\Cl)/C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
• RTECS: YE0875000
• Molecular Weight: 598.08
• Reaxy-Rn: 5223439
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5223439&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 31 mg/mL (199.75 mM); Ethanol: 31 mg/mL (199.75 mM); Water: Insoluble