Corticosterone - Moligand™, analytical standard , Agonist of Glucocorticoid receptor;Agonist of Mineralocorticoid receptor, CAS No.50-22-6, Agonist of Glucocorticoid receptor;Agonist of Mineralocorticoid receptor

CAS: 50-22-6 Cat. No.: C119329 Molecular Weight: 346.46 Beilstein Registry Number: 2339601 EC Number: 200-019-6
AVAILABLE TO ORDER
GRADE & PURITY Analytical standard ? Analytical standard — certified-purity material for quantitative calibration. Use to prepare calibration standards and validate analytical methods. Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
Synonyms
(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | A | HMS3713G06 | (11.beta.)-11,21-Dihydroxypregn-4-ene-3,20-dione | Corticosterone, 1mg/ml in Methanol | N
Storage
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
100mg
C119329-100mg
1
$144.90
500mg
C119329-500mg
1
$599.90
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™, analytical standard Analytical standard,Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 59 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Corticosteroid is an activator of MCR.

Specifications

Synonyms
(8S, 9S, 10R, 11S, 13S, 14S, 17S)-11-hydroxy-17-(2-hydroxyacetyl)-10, 13-dimethyl-1, 2, 6, 7, 8, 9, 11, 12, 14, 15, 16, 17-dodecahydrocyclopenta[a]phenanthren-3-one | A | HMS3713G06 | (11.beta.)-11, 21-Dihydroxypregn-4-ene-3, 20-dione | Corticosterone, 1mg/ml in Methanol | N
Specifications & Purity
Moligand™, analytical standard
Biochemical and Physiological Mechanisms
Corticosterone is a hormone synthesized in response to stress. It binds and activates MCRs(mineralocorticoid receptors) and GRs (glucocorticoid receptors), which results in altered expression. This eventually affects ionic conductances through the membran
Storage
Store at -20°C, Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Analytical standard, Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of Glucocorticoid receptor;Agonist of Mineralocorticoid receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Names and Identifiers
Canonical SmilesCC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O
IUPAC Name(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
InChIKeyOMFXVFTZEKFJBZ-HJTSIMOOSA-N
INCHI1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
Isomeric SMILES C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O
WGK Germany 3
RTECS GM7650000
Molecular Weight 346.46
Beilstein 2339601
Reaxy-Rn 2063664
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2063664&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
SubclassHydroxysteroids
Intermediate Tree Nodes Not available
Direct Parent21-hydroxysteroids
Alternative Parents Gluco/mineralocorticoids, progestogins and derivatives  20-oxosteroids  3-oxo delta-4-steroids  11-beta-hydroxysteroids  Delta-4-steroids  Cyclohexenones  Alpha-hydroxy ketones  Secondary alcohols  Cyclic alcohols and derivatives  Primary alcohols  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAliphatic homopolycyclic compounds
Substituents Progestogin-skeleton - 21-hydroxysteroid - Pregnane-skeleton - 20-oxosteroid - 3-oxo-delta-4-steroid - 3-oxosteroid - 11-hydroxysteroid - 11-beta-hydroxysteroid - Oxosteroid - Delta-4-steroid - Cyclohexenone - Alpha-hydroxy ketone - Cyclic alcohol - Ketone - Secondary alcohol - Cyclic ketone - Hydrocarbon derivative - Organic oxide - Carbonyl group - Organic oxygen compound - Alcohol - Organooxygen compound - Primary alcohol - Aliphatic homopolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
External Descriptors C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
NR3C1 Tclin Glucocorticoid receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC22A3 Tchem Solute carrier family 22 member 3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SHBG Tchem Sex hormone-binding globulin (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NR3C2 Tclin Mineralocorticoid receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SERPINA6 Tchem Corticosteroid-binding globulin (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C2 Tclin Mineralocorticoid receptor (2134 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SERPINA6 Tchem Corticosteroid binding globulin (274 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EBP Tchem 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase (102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR1H4 Tclin Bile acid receptor FXR (6228 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT1A4 Tbio UDP-glucuronosyltransferase 1A4 (288 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Caco-2 (12174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lymphoblastoid cell (5959 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC22A1 Tchem Solute carrier family 22 member 1 (646 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Skin (286 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B7 Tchem 3-keto-steroid reductase (330 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT2B15 Tbio UDP-glucuronosyltransferase 2B15 (172 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT1A1 Tchem UDP-glucuronosyltransferase 1-1 (448 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMN1 Tchem Survival motor neuron protein (34246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THPO Tbio Thrombopoietin (834 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC22A8 Tclin Solute carrier family 22 member 8 (241 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC22A2 Tchem Solute carrier family 22 member 2 (261 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC22A11 Tclin Solute carrier family 22 member 11 (82 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
ERG2 C-8 sterol isomerase (237 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sigmar1 Sigma opioid receptor (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcb1b P-glycoprotein 1 (174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nr1i3 Constitutive androstane receptor (427 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Shbg Testis-specific androgen-binding protein (10 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Galc Galactocerebrosidase (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc22a6 Solute carrier family 22 member 6 (141 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc22a5 Solute carrier family 22 member 5 (44 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NS1 Nonstructural protein 1 (33327 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc22a3 Solute carrier family 22 member 3 (35 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slco1a1 Solute carrier organic anion transporter family member 1A1 (265 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slco1a4 Solute carrier organic anion transporter family member 1A4 (114 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcb1a P-glycoprotein 1 and 3 (MDR1a/MDR1b) (23 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot NumberCertificate TypeDateItem
J2531127Certificate of AnalysisNov 11, 2025 C119329
J2531138Certificate of AnalysisNov 11, 2025 C119329
A2329595Certificate of AnalysisApr 18, 2025 C119329
A2329516Certificate of AnalysisNov 14, 2024 C119329
J2430118Certificate of AnalysisJan 11, 2023 C119329
D1922087Certificate of AnalysisDec 09, 2022 C119329
Chemical and Physical Properties
SolubilitySoluble in acetone, methanol, ethanol (10 mM), chloroform, and DMSO (100 mM). Insoluble in water.
SensitivityMoisture sensitive
Specific Rotation[α]+221 to +226 deg(C=1, EtOH)
Melt Point(°C)180-183°C
Molecular Weight346.500 g/mol
XLogP31.900
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass346.214 Da
Monoisotopic Mass346.214 Da
Topological Polar Surface Area74.600 Ų
Heavy Atom Count25
Formal Charge0
Complexity638.000
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Qing Zhu, Yuanshan Han, Ying He, Yilan Fu, Hui Yang, Yun Chen, Yingrui Shi.  (2023)  Kaempferol Improves Breast Cancer-Related Depression through the COX-2/PGE2 Pathway.  Frontiers in Bioscience-Landmark,  28  (11): (311).  [PMID:38062826] [10.31083/j.fbl2811311]
2. Nan Li, Juan Zheng, Lu-Dan Yu, Yuan-Jun Tong, Xinying Gong, Yu Hou, Guosheng Chen, Jianqiao Xu, Fang Zhu, Gangfeng Ouyang.  (2023)  Green, mildly synthesized bismuth-based MOF for extraction of polar glucocorticoids in environmental water.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:37716268] [10.1016/j.jhazmat.2023.132477]
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7. Li Sheng, Wang Zhi, Yao Jing Wen, Jiao Hong Chao, Wang Xiao Juan, Lin Hai, Zhao Jing Peng.  (2022)  Reduced PGC-1β protein expression may underlie corticosterone inhibition of mitochondrial biogenesis and oxidative phosphorylation in chicken muscles.  Frontiers in Physiology,      [PMID:36311241] [10.3389/fphys.2022.989547]
8. Sun Jia-Yi, Liu Yi-Tong, Jiang Sheng-Nan, Guo Peng-Mei, Wu Xin-Yu, Yu Jia.  (2022)  Essential oil from the roots of Paeonia lactiflora pall. has protective effect against corticosterone-induced depression in mice via modulation of PI3K/Akt signaling pathway.  Frontiers in Pharmacology,      [PMID:36188568] [10.3389/fphar.2022.999712]
9. Mingfa Sun, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Haifang Li, Yunlei Zhou, Hai Lin.  (2022)  Research Note: Creatine monohydrate alleviates protein breakdown induced by corticosterone via inhibiting ubiquitin proteasome pathway in chicken myotubes.  POULTRY SCIENCE,      [PMID:36194918] [10.1016/j.psj.2022.102177]
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11. Wang Yan, Zhou Sixu, Song Xujiao, Ding Shanshan, Wang Baogui, Wen Jiangfeng, Chen Chunlin.  (2022)  Study on Antidepressant Effect and Mechanism of Crocin Mediated by the mTOR Signaling Pathway.  NEUROCHEMICAL RESEARCH,  47  (10): (3126-3136).  [PMID:35804209] [10.1007/s11064-022-03668-z]
12. Chai Yuhui, Cai Yawen, Fu Yu, Wang Yingdi, Zhang Yiming, Zhang Xue, Zhu Lingpeng, Miao Mingxing, Yan Tianhua.  (2022)  Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway.  Frontiers in Pharmacology,      [PMID:35496273] [10.3389/fphar.2022.812362]
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23. Junying Li, Xiaoxiao Shan, Yu Gao, Haizhou Zhu, Hongyan Cheng, Chengjie Xing, Lele Zhou, Wenkang Tao, Yangyang Li, Baoqi Yin, Caiyun Zhang.  (2025)  Acori Tatarinowii Rhizoma regulates OCT3/OATP2 and P-gp/MRP1 to “guide medicines upwards” in Kai-Xin-San to treat Alzheimer's disease.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:39947370] [10.1016/j.jep.2025.119484]
24. Wenshan Yang, Yuanbo Wang, Xia Li, Rui Jing, Lihua Mu, Yuan Hu.  (2024)  Antidepressive and cardioprotective effects of Kai-xin-san via the regulation of HPA axis dysfunction and lipid metabolism in a rat model of depressive-cardiac disease.  BRAIN RESEARCH BULLETIN,      [PMID:39542048] [10.1016/j.brainresbull.2024.111126]
25. Li Tian, Wei Yao, Jiao Beibie, Hao Rui, Zhou Beibei, Bian Xinlan, Wang Peijuan, Zhou Yahong, Sun Xia, Zhang Jian.  (2024)  Bushen Huoxue formula attenuates lipid accumulation evoking excessive autophagy in premature ovarian insufficiency rats and palmitic acid-challenged KGN cells by modulating lipid metabolism.  Frontiers in Pharmacology,      [PMID:39351088] [10.3389/fphar.2024.1425844]
26. Liu Jie, Zhang Ke, Zhao Mindie, Chen Liang, Chen Huimin, Zhao Yulan, Zhao Ruqian.  (2024)  Dietary bile acids alleviate corticosterone-induced fatty liver and hepatic glucocorticoid receptor suppression in broiler chickens.  JOURNAL OF ANIMAL SCIENCE,      [PMID:39492782] [10.1093/jas/skae338]
27. Dihao Xie, Simin Zhong, Meixue Luo, Jiahao Xu, Ruoyan Zheng, Jiading Luo, Yiting Wang, Yongxing Guo, Lianxia Guo, Baojian Wu, Danyi Lu.  (2024)  Disruption of local circadian clocks in aristolochic acid-induced nephropathy in mice.  PHYTOMEDICINE,      [PMID:39541665] [10.1016/j.phymed.2024.156235]
28. Rui Liu, Xingya Sun, Yingjie Zhang, Peipei Li, Li Nan, Qing Shen, Kai Wen, Xuezhi Yu, Jianzhong Shen, Yantong Pan, Zhanhui Wang.  (2024)  Highly selective and sensitive immunoassays for flurogestone acetate analysis in goat milk: From rational hapten design and antibody production to assay development.  FOOD CHEMISTRY,      [PMID:38574526] [10.1016/j.foodchem.2024.139198]
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30. Hu Lili, Wu Na, Wang Jue, Cai Donghui.  (2025)  Network pharmacology combined with experimental verification for exploring the potential mechanism of phellodendrine against depression.  Scientific Reports,  15  (1): (1-11).  [PMID:39809809] [10.1038/s41598-024-84771-9]
31. Jia Yanjun, Wang Yanping, Wang Zixia, Zhang Zeyu, Zhang Ju, Zhang Jingjing, Sun Ke, Hua Yongchen, Chai Guolin, Hu Fangdi.  (2024)  Neuroprotective effects of total phenolics from Hemerocallis citrina Baroni leaves through the PI3K/AKT pathway.  Frontiers in Pharmacology,      [PMID:39070797] [10.3389/fphar.2024.1370619]
32. Mingyan Wang, Xin Wei, Yugai Jia, Chaonan Wang, Xinliu Wang, Xin Zhang, Depei Li, Yuanyuan Wang, Yonggang Gao.  (2024)  Quercetin alleviates chronic unpredictable mild stress‐induced depression‐like behavior by inhibiting NMDAR1 with α2δ‐1 in rats.  CNS Neuroscience & Therapeutics,      [PMID:38615365] [10.1111/cns.14724]
33. Qing Zhu, Yuanshan Han, Ying He, Pan Meng, Yilan Fu, Hui Yang, Gefei He, Minghui Long, Yingrui Shi.  (2024)  Quercetin inhibits neuronal ferroptosis and promotes immune response by targeting lipid metabolism-related gene PTGS2 to alleviate breast cancer-related depression.  PHYTOMEDICINE,      [PMID:38815404] [10.1016/j.phymed.2024.155560]
34. Shan Xing, Shuyi Xu, Linjiao Wang, Liyuan Guo, Xin Zhou, Haoxin Wu, Wei Wang, Lanying Liu.  (2024)  Salidroside exerts antidepressant-like action by promoting adult hippocampal neurogenesis through SIRT1/PGC-1α signalling.  ACTA NEUROPSYCHIATRICA,      [PMID:39344773] [10.1017/neu.2024.28]
35. Zibo Li, Ziyang Huang, Zhiyi Wang, Zhenzhen Guo, Baoying Wang, Yucheng Li, Erping Xu.  (2025)  Chaihu Longgu Muli Decoction inhibits chronic stress-induced lung cancer epithelial-mesenchymal transition process by suppressing Rap1/ERK signal pathway.  Frontiers in Pharmacology,      [PMID:40786046] [10.3389/fphar.2025.1644315]
36. Jingxin Chen, Jian Shi, Wenting Gu, Weiye Li, Ruiyin Lyu, Xueping Wu, Junming Wang, Chunhong Liu.  (2025)  Multi-Target Antidepressant Action of Citrus medica L. var. sarcodactylis Swingle (Bergamot) Essential Oil: From PI3K/AKT-Driven Apoptosis Inhibition to BDNF/5-HT Signaling Activation.  SOUTH AFRICAN JOURNAL OF BOTANY,      [PMID:] [10.1016/j.sajb.2025.07.033]
37. Chen Rong, Wang Mingyu, Nie Hailiang, Zhang Jinku, Yan Hongyuan.  (2025)  Carbon quantum dot-aptamer/MoS2 nanosheet fluorescent sensor for ultrasensitive, noninvasive cortisol detection.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,      [PMID:40924161] [10.1007/s00216-025-06086-6]
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40. Ma Qi, Ma Yu, Sun Shizhuo, Yang Lei, Shi Tian, Zhang Boxi, Shang Bo, Zhou Ruiyuan, Liu Jingyuan, He Jiao, Hu Jing, Cao Yanjun.  (2025)  Geniposide Improves Corticosterone-induced Toxicity in PC12 Cells through the NMDARs and BDNF Pathway.  CELL BIOCHEMISTRY AND BIOPHYSICS,      [PMID:40742508] [10.1007/s12013-025-01856-6]
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43. Siqi Sun, Jingtong Rong, Chao Wang, Ruiling Li, Honghan Zhang, Wei Wang, Hao Duan, Zhaowen Nie, Dan Xiang, Zhongchun Liu.  (2025)  Intranasal administration of exosomes derived from adipose mesenchymal stem cells ameliorates depressive-like behaviors and inhibits inflammation via AMPK/mTOR-mediated autophagy.  JOURNAL OF AFFECTIVE DISORDERS,      [PMID:40250814] [10.1016/j.jad.2025.04.059]
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50. Longxia Lan, Jinfeng Chen, Yuemei Chen, Jiajia Han, Yang Yu, Shaohan Wang, Guosheng Chen, Junlang Qiu, Fang Zhu, Gangfeng Ouyang.  (2025)  Disturbance of endogenous glucocorticoid levels by phenicol antibiotics in living fish.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:41308451] [10.1016/j.jhazmat.2025.140587]
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53. Huang Huang, Xiuhui Guo, Siqi Quan, Xiangli Yan, Yucheng Li, Erping Xu.  (2025)  UPLC-MS/MS and network pharmacology-based antidepressant study of Chaihu Jia Longgu Muli decoction.  Letters in Drug Design & Discovery,      [PMID:] [10.1016/j.lddd.2025.100192]
54. Rui Hao, Tian Li, Beibei Zhou, Jiaxin Shao, Weibo Zhao, Beibei Jiao, Xia Sun, Jian Zhang.  (2025)  Bushen Huoxue Formula Alleviates Lipid Accumulation in Premature Ovarian Insufficiency by Activating the LRP6/β-catenin Signaling Pathway.  PHYTOMEDICINE,      [PMID:41477980] [10.1016/j.phymed.2025.157726]
55. Jian Liu, Yeqing Liu, Changtie Liu, Jing Wang, Yuanyi Zhang, Yuxing Yang, Si Peng, Rongrong Xu, Lingxiang Xu, Xingchen Wang, Wei Xiong, Yun Gao.  (2026)  Jujuboside A alleviates visceral pain and depression comorbidity and modulates the P2X7R-BDNF signaling axis.  PHYTOMEDICINE,      [PMID:41547067] [10.1016/j.phymed.2026.157764]
56. Zhao Chen-di, Liu Nan-feng, Samad Abdus, Tian Zhen, Xu Hong-mei, Tian Jiao.  (2026)  Neferine alleviated corticosterone-induced depressive-like behaviors in mice via the inhibition of TNF/NF-κB pathway by binding to PPARγ.  MOLECULAR NEUROBIOLOGY,  63  (1): (374).  [PMID:41553445] [10.1007/s12035-025-05659-x]
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59. Jiang Cheng, Naihui Hou, Tengda Wang, Zhenyun Zhao\u003Csup\u003E*\u003C\u002Fsup\u003E, Wei Chen\u003Csup\u003E*\u003C\u002Fsup\u003E.  (2026)  Dual-function core-shell nanocube probes enabling continuous production of cortisol-sensing yarns via conjugate electrospinning.  Soft Science,  (2): (N).  [PMID:] [10.20517/ss.2025.123]
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