CP-601932 - 10mM in DMSO , CAS No.357425-68-4

CAS: 357425-68-4 Cat. No.: C655983 Formule: C₁₂H₁₂F₃N Poids moléculaire: 227.23 PubChem CID: 69604735

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

CP-601932 ((1S,5R)-CP-601927) is a high-affinity partial agonist at α3β4 nAChR ( K i =21 nM; EC 50 =~ 3 μM). CP-601932 has the same high-binding affinity at α4β2 nAChR (K i =21 nM) and an order of magnitude lower affinity for α6 and α7 nAChR subtypes. CP-601932 selectively decreases ethanol but not sucrose consumption and operant self-administration following long-term exposure. CP-601932 can penetrate the CNS.

In Vivo

CP-601932 (10 mg/kg; s.c; adult male Sprague-Dawley rats) decreases active lever presses for 10% ethanol, but not 5% sucrose in the operant self-administration paradigm . CP-601932 (adult male Sprague-Dawley rats) readily penetrates the CNS and at 30 min reaches maximal C b,u values of 340 nM after 5 mg/kg and 710 nM after 10 mg/kg. Brain concentrations of CP-601932 decline very slowly and levels stay relatively high, eg, 530 nM at 5 h and 85 nM at 24 h after 10 mg/kg . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

CP-601932 ((1S,5R)-CP-601927) is a high-affinity partial agonist at α3β4 nAChR ( K i =21u2009nM; EC 50 =~ 3u2009μM). CP-601932 has the same high-binding affinity at α4β2 nAChR (K i =21u2009nM) and an order of magnitude lower affinity for α6 and α7 nAChR s

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

AGONIST

Noms et identifiants

• Isomères SMILES: C1[C@@H]2CNC[C@H]1C3=C2C=CC(=C3)C(F)(F)F
• CAS alternatif: 357425-68-4
• PubChem CID: 69604735
• Termes d'entrée MeSH: CP 601932;CP-601932;CP601932
• Poids moléculaire: 227.23