CP376395 - Moligand™, ≥98% , Antagonist of CRF 1 receptor, CAS No.175140-00-8, Antagonist of CRF 1 receptor

CAS: 175140-00-8 Cat. No.: C412543 Formule: C₂₁H₃₀N₂O Poids moléculaire: 326.49

GRADE & PURITY Moligand™, ≥98%

Synonyms

VIZBSVDBNLAVAW-UHFFFAOYSA-N | BDBM20966 | 5113G7FP34 | UNII-5113G7FP34 | compound 3a [PMID: 18288792] | GTPL3496 | 3,6-Dimethyl-N-(Pentan-3-Yl)-2-(2,4,6-Trimethylphenoxy)pyridin-4-Amine | AKOS015994585 | CP-376,395 | 4k5y | CP 376395 | GD-0065 | CP-376395

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Information

CP376395 CP 376395 is a potent and selective antagonist of corticotropin releasing factor 1 (CRF1) receptor.

Specifications

Synonymes

VIZBSVDBNLAVAW-UHFFFAOYSA-N | BDBM20966 | 5113G7FP34 | UNII-5113G7FP34 | compound 3a [PMID: 18288792] | GTPL3496 | 3,6-Dimethyl-N-(Pentan-3-Yl)-2-(2,4,6-Trimethylphenoxy)pyridin-4-Amine | AKOS015994585 | CP-376,395 | 4k5y | CP 376395 | GD-0065 | CP-376395

Spécifications et pureté

Moligand™, ≥98%

Mécanismes biochimiques et physiologiques

CP 376395 is a potent and selective antagonist of corticotropin releasing factor 1 (CRF1) receptor. CP-376395 is a potent and selective antagonist of the CRF1 receptor, which has been shown to play an important role in mediating behavioral and endocrine r

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

ANTAGONIST

Mécanisme d'action

Antagonist of CRF 1 receptor

Pureté

≥98%

Noms et identifiants

• Pubchem Sid: 504765001
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504765001
• Sourires canoniques: CCC(CC)NC1=C(C(=NC(=C1)C)OC2=C(C=C(C=C2C)C)C)C
• IUPAC Name: 3,6-dimethyl-N-pentan-3-yl-2-(2,4,6-trimethylphenoxy)pyridin-4-amine
• InChIKey: VIZBSVDBNLAVAW-UHFFFAOYSA-N
• INCHI: 1S/C21H30N2O/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3,(H,22,23)
• Isomères SMILES: CCC(CC)NC1=C(C(=NC(=C1)C)OC2=C(C=C(C=C2C)C)C)C
• Poids moléculaire: 326.49
• Reaxy-Rn: 13255678
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13255678&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Classe Organooxygen compounds
      • Subclass Ethers

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Classe: Organooxygen compounds
• Subclass: Ethers
• Intermediate Tree Nodes: Not available
• Direct Parent: Diarylethers
• Alternative Parents: Phenoxy compounds Phenol ethers Secondary alkylarylamines Methylpyridines Aminopyridines and derivatives Heteroaromatic compounds Azacyclic compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Diaryl ether - Phenoxy compound - Phenol ether - Aminopyridine - Methylpyridine - Secondary aliphatic/aromatic amine - Monocyclic benzene moiety - Pyridine - Benzenoid - Heteroaromatic compound - Organoheterocyclic compound - Azacycle - Secondary amine - Organonitrogen compound - Amine - Hydrocarbon derivative - Organic nitrogen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as diarylethers. These are organic compounds containing the dialkyl ether functional group, with the formula ROR', where R and R' are aryl groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

CRHR1 Tclin Corticotropin-releasing factor receptor 1 (2 Activities)

Discover Target: CRHR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CRHR1 Tclin Corticotropin releasing factor receptor 1 (2996 Activities)

Discover Target: CRHR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CRHR2 Tchem Corticotropin releasing factor receptor 2 (399 Activities)

Discover Target: CRHR2

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Liver microsomes (16955 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Canis familiaris (36305 Activities)

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Rattus norvegicus (775804 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Solubility (25°C) In vitro Ethanol: mg/mL
• Poids moléculaire: 326.500 g/mol
• XLogP3: 6.400
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 326.236 Da
• Monoisotopic Mass: 326.236 Da
• Topological Polar Surface Area: 34.200 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 359.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1