CRT0066854 - 10mM in DMSO , CAS No.1438881-19-6

CAS: 1438881-19-6 Cat. No.: C656506 Formule: C₂₄H₂₅N₅S Poids moléculaire: 415.55 PubChem CID: 70702288

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCι , PKCζ , and ROCK-II kinases with IC 50 values of 132 nM, 639 nM, and 620 nM, respectively

In Vitro

CRT0066854 displaces a crucial Asn-Phe-Asp motif that is part of the adenosine-binding pocket and engages an acidic patch used by arginine-rich PKC substrates. CRT0066854 (0.2-1.2 μM; 6 days) is able to restore polarized morphogenesis in the dysplastic H-Ras spheroids, and the maximal proportion of spheroids with PSALs is at the lower dose of 1.2 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:PKCζ 639 nM (IC 50 ) ROCK2 620 nM (IC 50 )

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCι , PKCζ , and ROCK-II kinases with IC 50 values of 132 nM, 639 nM, and 620 nM, respectively.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Noms et identifiants

Isomères SMILES

C1CCC2=C(C1)C3=C(N=C(N=C3S2)C4=CC=NC=C4)NC[C@H](CC5=CC=CC=C5)N

PubChem CID

70702288

Termes d'entrée MeSH

3-phenyl-N(1)-(2-pyridin-4-yl-5,6,7,8-tetrahydrobenzo(4,5)thieno(2,3-d)pyrimidin-4-yl)-propane-1,2-diamine;CRT0066854

Poids moléculaire

415.55