Curcumin analog C1 - ≥97% , CAS No.39777-61-2

CAS: 39777-61-2 Cat. No.: C413625 Formule: C₁₉H₁₈O₃ Poids moléculaire: 294.34 Numéro CE: 873-543-1

QUALITÉ & PURETÉ ≥97%

Synonyms

MFCD00719180 | (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1, | AB00092085-01 | TFEB activator 1 | D82401 | BDBM50285603 | TFEB activator 1; ABM-7612 | S6769 | 1,5-bis-(2-methoxyphenyl)-1,4-pentadien-3-one | 1,5-bis(2-methoxyphenyl)-1,4-pentadien-3-one | (1E,4E

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Information

Curcumin analog C1 (Curcumin analog Compound C1) is a potenttranscription factor EB (TFEB)activator with promise for the prevention or treatment of Alzheimer's disease.

Spécifications

Synonymes

MFCD00719180 | (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1, | AB00092085-01 | TFEB activator 1 | D82401 | BDBM50285603 | TFEB activator 1; ABM-7612 | S6769 | 1,5-bis-(2-methoxyphenyl)-1,4-pentadien-3-one | 1,5-bis(2-methoxyphenyl)-1,4-pentadien-3-one | (1E,4E

Spécifications et pureté

≥97%

Mécanismes biochimiques et physiologiques

TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway an

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥97%

Noms et identifiants

Pubchem Sid

504760246

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504760246

Sourires canoniques

COC1=CC=CC=C1C=CC(=O)C=CC2=CC=CC=C2OC

IUPAC Name

(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one

InChIKey

RCZMPCUUTSDNAJ-PHEQNACWSA-N

INCHI

1S/C19H18O3/c1-21-18-9-5-3-7-15(18)11-13-17(20)14-12-16-8-4-6-10-19(16)22-2/h3-14H,1-2H3/b13-11+,14-12+

Isomères SMILES

COC1=CC=CC=C1/C=C/C(=O)/C=C/C2=CC=CC=C2OC

Poids moléculaire

294.34

Reaxy-Rn

2335342

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2335342&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Phenol ethers
      • Subclass Anisoles

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Phenol ethers
• Subclass: Anisoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Anisoles
• Alternative Parents: Styrenes Phenoxy compounds Methoxybenzenes Alkyl aryl ethers Enones Acryloyl compounds Ketones Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Phenoxy compound - Anisole - Styrene - Methoxybenzene - Alkyl aryl ether - Monocyclic benzene moiety - Enone - Acryloyl-group - Alpha,beta-unsaturated ketone - Ketone - Ether - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Organic oxide - Organic oxygen compound - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as anisoles. These are organic compounds containing a methoxybenzene or a derivative thereof.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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HL-60 (67320 Activities)

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RPMI-7951 (420 Activities)

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HCT-116 (91556 Activities)

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KB (17409 Activities)

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HeLa (62764 Activities)

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MDA-MB-231 (73002 Activities)

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Cibles associées (non humaines)

Plasmodium falciparum (966862 Activities)

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Luciferin 4-monooxygenase (66902 Activities)

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: DMSO: 59 mg/mL (200.45 mM)Ethanol: 2 mg/mL (6.79 mM)
• Poids moléculaire: 294.300 g/mol
• XLogP3: 4.100
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 294.126 Da
• Monoisotopic Mass: 294.126 Da
• Topological Polar Surface Area: 35.500 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 363.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 1