Cycloheximide (NSC-185) - Moligand™, 10mM in DMSO , 80S Ribosome inhibitor, CAS No.66-81-9, 80S Ribosome inhibitor

CAS: 66-81-9 Cat. No.: C408230 Molecular Weight: 281.35 EC Number: 200-636-0
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GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
Synonyms
Actidione, Naramycin A, CHX, FT 3422-2, NM-MCD 80 | 4-[2-(3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs,FedEx DG Service
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Size
Status
Price
Qty
1ml
C408230-1ml
2

$203.90

$237.90
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Why this grade

Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs,FedEx DG Service Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 109 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

Cycloheximide (NSC-185) Cycloheximide (NSC-185, Actidione, Naramycin A, CHX, FT 3422-2, NM-MCD 80), an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo,
In vitro


In vivo


Cell Data

cell lines:HT29, Colo205, PC-3, MDA-MB-231 and K562 cells

Concentrations:

Incubation Time:

Powder Purity:≥97%

Specifications

Synonyms
Actidione, Naramycin A, CHX, FT 3422-2, NM-MCD 80 | 4-[2-(3, 5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxyethyl]-2, 6-piperidinedione
Specifications & Purity
Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms
Cycloheximide (NSC-185, Actidione, Naramycin A, CHX, FT 3422-2, NM-MCD 80), an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. Cycloheximid
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs, FedEx DG Service
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
80S Ribosome inhibitor
Product Properties
ALogP0.5
Names and Identifiers
Isomeric SMILES C[C@H]1C[C@@H](C(=O)[C@@H](C1)[C@@H](CC2CC(=O)NC(=O)C2)O)C
UN Number 2811
Packing Group II
Molecular Weight 281.35
Reaxy-Rn 9515475
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9515475&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Associated Targets(Human)
EIF4A1 Tchem Eukaryotic initiation factor 4A-I (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC2A1 Tchem Solute carrier family 2, facilitated glucose transporter member 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
SolubilitySolubility (25°C) In vitro DMSO: 53 mg/mL (79.62 mM); Water: Insoluble; Ethanol: Insoluble;
Flash Point(°F)230°F
Flash Point(°C)>110°C
Boil Point(°C)492°C
Melt Point(°C)119.5-121°C
Documents & Articles
How Antibiotics Halt Bacterial Protein Synthesis (With Representative Products and a Selection Guide)
Small-Molecule Inhibitors: A Practical Guide for Research Selection — A Minimal Evidence Chain and Scenario-Based Validation Framework (Including a Selection Matrix, Case Cards, and Product Tables 1–4)
Azithromycin: Physicochemical Features, Mechanism of Action, and Key Points for Research Applications
Interleukin-29 (IL-29/IFN-λ1): Molecular Features, Signaling Networks, and a Systematic Framework for Research Applications
Furin: A Review of Its Structural Features, Substrate Recognition, and Research Applications
How to Determine Whether a Protein Is Suitable for Targeted Degradation: From Degradation Pathway and Molecular Design to Mechanism Validation
Experimental Research on Candidate Probiotics: From Strain Identification and Mechanistic Evaluation to Product Selection
Citations of This Product
References
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51. Yumeng Sui, Xiangao Li, Yuan Gao, Baohua Kong, Yitong Jiang, Qian Chen.  (2024)  Effect of Yeast Inoculation on the Bacterial Community Structure in Reduced-Salt Harbin Dry Sausages: A Perspective of Fungi–Bacteria Interactions.  Foods,  13  (2): (307).  [PMID:38254608] [10.3390/foods13020307]
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53. Xinyue Zhao, Zhihui Han, Ruiying Liu, Zehao Li, Ling Mei, Yue Jin.  (2024)  FBXO11 Mediates Ubiquitination of ZEB1 and Modulates Epithelial-to-Mesenchymal Transition in Lung Cancer Cells.  Cancers,  16  (19): (3269).  [PMID:39409891] [10.3390/cancers16193269]
54. Zhen Xu, Yilin Guo, Lu Wang, Jinquan Cui.  (2024)  HECW1 restrains cervical cancer cell growth by promoting DVL1 ubiquitination and downregulating the activation of Wnt/β-catenin signaling.  EXPERIMENTAL CELL RESEARCH,      [PMID:38266865] [10.1016/j.yexcr.2024.113949]
55. Xing Wang, Feiyang Deng, Tianyi Ji, Chengning Zhang, Yang Tian, Hui Zhang, Aiping Zheng, Ying Chen, Bing He, Wenbing Dai, Hua Zhang, Qiang Zhang, Xueqing Wang.  (2024)  Impact of Physiological Characteristics on Chylomicron Pathway-Mediated Absorption of Nanocrystals in the Pediatric Population.  ACS Nano,      [PMID:39153194] [10.1021/acsnano.4c05391]
56. Yang Liu, Yaokang Wu, Xueqin Lv, Ku Li, Jian Xiong, Xiao Liu, Jianghua Li, Long Liu, Guocheng Du, Jian Chen, Yanfeng Liu.  (2024)  Improving Cellular Protein Content of Saccharomyces cerevisiae Based on Adaptive Evolution and Flow Cytometry-Aided High Throughput Screening.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:39723951] [10.1021/acs.jafc.4c09632]
57. Yizeng Fan, Weichao Dan, Yuzhao Wang, Zhiqiang Ma, Yanlin Jian, Tianjie Liu, Mengxing Li, Zixi Wang, Yi Wei, Bo Liu, Peng Ding, Yuzeshi Lei, Chendong Guo, Jin Zeng, Xiaolong Yan, Wenyi Wei, Lei Li.  (2025)  Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1.  Cell Metabolism,      [PMID:39809284] [10.1016/j.cmet.2024.11.012]
58. Xiaoli Lu, Shangwen Sun, Na Li, Shuying Hu, Yuyao Pan, Lin Wang, Xuefeng Zhou, Hanbang Chen, Feimin Zhang.  (2024)  Janus sponge/electrospun fibre composite combined with EGF/bFGF/CHX promotes reconstruction in oral tissue regeneration.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:39084056] [10.1016/j.colsurfb.2024.114117]
59. Wan Xinyi, Zeng Weiwu, Fan Haonan, Wang Chenliang, Han Shixun, Sun Zhongxing, Tang Mei, Shao Juejia, Liu Yu, Fang Yuan, Jia Junqi, Tang Yin, Zhang Yanjun, Zhao Bin, Fang Dong.  (2024)  MAT2B regulates the protein level of MAT2A to preserve RNA N6-methyladenosine.  Cell Death & Disease,  15  (10): (1-16).  [PMID:39353892] [10.1038/s41419-024-07093-8]
60. Hong-Yu Fu, Yue Li, Han Cui, Jiu-Zhi Li, Wan-Xue Xu, Xi Wang, Rui-Feng Fan.  (2024)  miR-15b-5p promotes HgCl2-induced chicken embryo kidney cells ferroptosis by targeting β-TrCP-mediated ATF4 ubiquitin degradation.  TOXICOLOGY,      [PMID:38325558] [10.1016/j.tox.2024.153742]
61. Shen Yifen, Zhang Le, Yang Tao, Li Xiaosong, Liu Chao, Li Hongmei, Hu Yanping, Shen Hao, Li Hua, Orlov Yuriy L., Zhou Shasha, Shen Yihang.  (2024)  Monosome Stalls the Translation Process Mediated by IGF2BP in Arcuate Nucleus for Puberty Onset Delay.  MOLECULAR NEUROBIOLOGY,      [PMID:39235646] [10.1007/s12035-024-04450-8]
62. Hong Guo, Yuanwei Dong, Danqing Luo, Meng Gong, Jianfeng Sun, Zhipeng Wu, Zhixiang Liu, Lei Zhong, Song Jin.  (2024)  MRPL41, as a target for acupuncture, promotes neuron apoptosis in models of ischemic stroke via activating p53 pathway.  NEUROCHEMISTRY INTERNATIONAL,      [PMID:39406282] [10.1016/j.neuint.2024.105881]
63. Guoqiang Xing, Hekai Chen, Zhiyue Guo, Yu Cui, Yongyuan Li, Jianwei Shen.  (2024)  OTUD6B promotes cholangiocarcinoma growth by regulating STAT3 phosphorylation through deubiquitination of PTK2.  CELL BIOLOGY INTERNATIONAL,      [PMID:39192576] [10.1002/cbin.12234]
64. Fei Xiaobin, Zhu Changhao, Liu Peng, Liu Songbai, Ren Likun, Lu Rishang, Hou Junyi, Gao Yongjia, Wang Xing, Pan Yaozhen.  (2024)  PELI1: key players in the oncogenic characteristics of pancreatic Cancer.  JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,  43  (1): (1-20).  [PMID:38528516] [10.1186/s13046-024-03008-9]
65. Mengzhen Gu, Xiaoqing Xu, Xiaoping Wang, Yun Wang, Yu Zhao, Xiaoxian Hu, Lu Zhu, Zhenzhong Deng, Chao Han.  (2024)  Target Ligand Separation and Identification of Isoforsythiaside as a Histone Lysine-Specific Demethylase 1 Covalent Inhibitor Against Breast Cancer Metastasis.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:39499621] [10.1021/acs.jmedchem.4c02277]
66. Zheng Wang, Mingyu Zhao, Yue Su, Qiangsen Zhao, Zhenhua Ma, Qiaoxian Yue, Zhiwei Zhu, Lihuan Zhang, Zhuocheng Hou, Huifeng Li.  (2024)  The impact of NUMB on chicken abdominal adipogenesis: A comprehensive analysis.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39168214] [10.1016/j.ijbiomac.2024.134904]
67. Chanyu Wu, Xiaohan Wang, Xincan Li, Hexian Li, Qiuyue Peng, Xiaoxin Niu, Yutong Wu, Zhiying Wang, Zuoyong Zhou.  (2025)  TRIM21 interacts with IκBα and negatively regulates NF-κB activation in Corynebacterium pseudotuberculosis-infected macrophages.  VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,      [PMID:40020570] [10.1016/j.vetimm.2025.110910]
68. Yang Yanfang, Wang Tao, Fu Yuyin, Li Xukui, Yu Fuxun.  (2025)  TRIM28 functions as SUMO ligase to SUMOylate TRAF6 and regulate NF-κB activation in HBV-replicating cells.  Hepatology International,      [PMID:39920527] [10.1007/s12072-025-10779-6]
69. Gao Bai, Jing Yuchen, Li Xi, Cong Shuyan.  (2025)  Ubiquitin specific peptidase 11 knockdown slows Huntington’s disease progression via regulating mitochondrial dysfunction and neuronal damage depending on PTEN-mediated AKT pathway.  MOLECULAR MEDICINE,  31  (1): (1-20).  [PMID:39780069] [10.1186/s10020-024-01061-w]
70. Meng Xiangchao, Chen Hongye, Tan Zhihui, Yan Weitao, Liu Yinfeng, Lv Ji, Han Meng.  (2024)  USP53 Affects the Proliferation and Apoptosis of Breast Cancer Cells by Regulating the Ubiquitination Level of ZMYND11.  BIOLOGICAL PROCEDURES ONLINE,  26  (1): (1-18).  [PMID:39044157] [10.1186/s12575-024-00251-4]
71. Yirui Hong, Xinyu Zhang, Wenni Rong, Chenwei Hu, Yujie Jiang, Jiayi Xu, Huimin Wen, Fangjian Feng, C. Benjamin Naman, Haowei Shen, Shan He, Lijian Ding, Wei Cui.  (2025)  Uncovering the therapeutic potentials of marine-derived natural compounds with small amounts for neurological disorders.  GENE,      [PMID:40189165] [10.1016/j.gene.2025.149465]
72. Hai-Yan Wu, Lei Wang, Bing-Qi Yao, Shu-Xian Hou, Xiao-Bin Zheng.  (2025)  Tangeretin alleviates myocardial ischemia-reperfusion injury by inhibiting ferroptosis via targeting nicotinamide phosphoribosyltransferase (NAMPT).  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:40185323] [10.1016/j.ejphar.2025.177568]
73. Liang Ruopeng, Zhang Xiaoxue, Wu Shitao, Liu Jing, Zhai Yunpeng, Lin Chaojie, Wang Zhenya, Zhang Yi, Chen Hao, Zhu Rongtao.  (2025)  Deubiquitination of DNM1L by USP3 triggers the development and metastasis of gallbladder carcinoma.  Biology Direct,  20  (1): (1-18).  [PMID:40197257] [10.1186/s13062-025-00637-8]
74. Qian Wang, Tao Zhang, Xuemei Liu, Shuo Liu, Xinyue Wang, Xiaoming Wang.  (2025)  The fate of 6:2 fluorotelomer alcohol in anaerobic landfill leachate: Implication for fugitive emission from waste landfills.  ENVIRONMENTAL POLLUTION,      [PMID:40334735] [10.1016/j.envpol.2025.126375]
75. Xinyue Zhao, Ruiying Liu, Zhihui Han, Zehao Li, Ling Mei, Yuyang Liu, Xueqi Fu, Yue Jin.  (2025)  UBR5 regulates the progression of colorectal cancer cells through Snail-induced epithelial–mesenchymal transition.  Genes & Diseases,      [PMID:41492476] [10.1016/j.gendis.2025.101679]
76. Xiaofeng Ma, Wang chen, Zhihao Hu, Like Xie, Zhaobing Li, Huan Liu, Zili Li, Zhentao Jiang, Jiangwei Huang, Changrong Jiang, Ke Huang, Sujun Xiao.  (2025)  Trim65 mitigates doxorubicin-induced myocardial injury by reducing ferroptosis.  EXPERIMENTAL CELL RESEARCH,      [PMID:40447212] [10.1016/j.yexcr.2025.114613]
77. Ying Feng, Jiamei Yue, Si Fan, Jiayan Wu.  (2025)  The SOX18-OTUB1-YAP1 axis: a new endometriosis target.  Journal of Translational Medicine,      [PMID:40500704] [10.1186/s12967-025-06677-y]
78. Kai-Kai Lu, Hong Yang, Cai-Yi Liao, Ru-Feng Song, Xiao-Yu Hu, Feng Ren, Wen-Cheng Liu.  (2025)  A transcriptional recognition site within SOS1 coding region controls salt tolerance in Arabidopsis.  DEVELOPMENTAL CELL,      [PMID:40499547] [10.1016/j.devcel.2025.05.010]
79. Shushu Jiang, Shichen Bu, Xiang Kang, Yin Dong, Long Chen, Lin Yuan, Menghao Shi, Meng Du, Minglu Liang, Kai Huang, Liu Yang.  (2025)  Tspan9 Exacerbates Cardiac Hypertrophy by Impairing Cardiac Autophagy.  FASEB JOURNAL,  39  (10): (e70670).  [PMID:40406987] [10.1096/fj.202500150R]
80. Shangzai Wu, Xiaolong Gong, Guojian Ren, Linglong Yi, Qi Zhou, Qinhe Pan.  (2025)  Fluorescent Detection of Salicylaldehyde Based on Tb-Based Coordination Polymer.  ChemPlusChem,      [PMID:40536764] [10.1002/cplu.202500179]
81. Di Wang, Xiao-ya Wang, Wen-jing Li, Cheng-hui Liang, Yu-xin Zou, Jin-wei Xiao, Qing-mei Kang, Jun-han Wang, Ling Mao, Jun-jie Chen, Xue-jia Zhai, Ji-tao Zhuang, Xian-Yan Yang, Hong-ying Jiang, Tian-hua Shen, Jie Liu, Qian Wen, Jiang-jie Duan, Jun Wang, Shi-cang Yu.  (2025)  Phosphorylation of c-Myc at Ser62 via the protein kinase activity of acetaldehyde dehydrogenase 18A1 promotes tumor growth.  MOLECULAR THERAPY,      [PMID:40886047] [10.1016/j.ymthe.2025.08.036]
82. He Xin, Chuanzhuo Wang, Yuan Chi, Zhaoyu Liu.  (2025)  Deubiquitinase USP53 suppressed tumorigenesis of colorectal cancer cells by mediating deubiquitination of MORF4L1.  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,      [PMID:41061828] [10.1016/j.bbadis.2025.168067]
83. Zhang Pengchao, Cheng Jian, Liu Zhao, Adeshakin Funmilayo O., Dai Liujiang, Niu Xiangyun, Zhang Ziyang, Peng Xixia, Li Long, Liu Maoxuan, Yan Dehong, Yang Xiaolu, Wan Xiaochun, Zhang Guizhong.  (2025)  NY-ESO-1 facilitates anoikis resistance and tumor metastasis by hijacking deubiquitinase OTUB1 to stabilize PP1α.  Cell Death & Disease,  16  (1): (1-14).  [PMID:41053024] [10.1038/s41419-025-08017-w]
84. Yunfei Li, Cheng Cheng, Mingfei Li, Yi Hou, Jie Li, Shichao Duan, Enyi Gao, Ke Liu, Zhipeng Dai.  (2025)  CRIP1 exacerbates osteoarthritis progression by recruiting UBE3A to induce the ubiquitination-mediated degradation of MFGE8.  BIOCHEMICAL PHARMACOLOGY,      [PMID:41067282] [10.1016/j.bcp.2025.117407]
85. Jie Yang, Xue Wen, Yi-Tong Fu, Chao Li, Hai-Long Chang, Yao-Yao Lu, Xue-Ru Li, Rui-Feng Fan.  (2025)  NCOA4-dependent ferritinophagy drives perfluorooctanoic acid-triggered renal ferroptosis in chicken embryos.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:41109030] [10.1016/j.jhazmat.2025.140112]
86. Li Yuan, Liu Wenna, Fan Xushen, Wu Xinyi, Cao Mingbo, Li Xiuling, Wurita Amin, Sun Suofeng.  (2025)  FAIM modulates HCC progression via enhancing HMGA1 interaction with CDK7 and promoting its phosphorylation level.  Journal of Translational Medicine,  23  (1): (1-15).  [PMID:41094644] [10.1186/s12967-025-07148-0]
87. Wei Zhang, Wenting Zhu, Xiao Liu, Silong Yuan, Da Li, He Huang, Xiaoming Huang, Lei Wang, Honggang Zhang.  (2025)  Gypenoside XLIX targets SIRT1 to block YAP-NLRP3 activation and improve sepsis-induced cardiomyopathy.  PHYTOMEDICINE,      [PMID:41265259] [10.1016/j.phymed.2025.157527]
88. Zheng Ge, Zitian Liu, Shuohui Dong, Xiang Zhao, Guangwei Yang, Ao Yu, Wei Guo, Xiang Zhang, Qunzheng Wu, Kexin Wang.  (2025)  High-Fat Diet Induces Senescence in ADSCs via CDK4 Ubiquitination-Mediated Cell Cycle Disruption, Contributing to Impaired Glucose Tolerance.  Molecular Metabolism,      [PMID:41319797] [10.1016/j.molmet.2025.102293]
89. Yichun Wu, Xing Wang, Lingyu Meng, Zhizhao Liao, Wei Ji, Peipei Zhang, Jie Lin, Qiang Guo.  (2025)  Translation landscape of stress granules.  Science Advances,  11  (40):   [PMID:41042876] [10.1126/sciadv.ady6859]
90. Rui-Shi Wei, Yong-Ping Liu, Chun-Dong Gu, Shi-Lei Zhao, Li Feng, Jian-Rong Yu.  (2025)  USP54 Promotes Ferroptosis in Non-Small Cell Lung Cancer by Mediating FOXA2 Deubiquitination and Enhancing ACSL4 Transcription.  KAOHSIUNG JOURNAL OF MEDICAL SCIENCES,      [PMID:41267551] [10.1002/kjm2.70139]
91. Yanyang Fu, Jixing Wu, Jian Shi, Changjun Jia.  (2025)  E3 Ubiquitin Ligase TRIM47 Promotes Intrahepatic Cholangiocarcinoma Progression by Ubiquitinating Fumarate Hydratase and Modulating Macrophage Polarization.  JOURNAL OF BIOLOGICAL CHEMISTRY,      [PMID:41380966] [10.1016/j.jbc.2025.111035]
92. Hui Jia, Xiaowen Liu, Hui Chen, Yanli Wang, Min-Xin Guan, Yufen Guo.  (2025)  Pathogenic Mechanism of the KCNQ4 Gene Variant in Hearing Loss and Functional Validation in a Zebrafish Model.  FASEB JOURNAL,  39  (23): (e71274).  [PMID:41368761] [10.1096/fj.202500557R]
93. Ning Han, Liu-Gen Li, Mei-Yi Liu, Tao Ren, Yao-Hua Lu, Xing-Chun Peng, Cunqing Kong, Fan Leng, Lei Zhang, Jun Hu, Lei Wang, Tong-Fei Li, Mei-Fang Wang, Xiao Chen.  (2025)  Harringtonine Elicits Ferroptosis by Regulating SYVN1-Mediated FASN Ubiquitination for Evoking Anti-Lung Cancer Efficacy.  PHYTOTHERAPY RESEARCH,      [PMID:41388624] [10.1002/ptr.70130]
94. Lingyan Chen, Dejian Chen, Fengzhuo Yang, Xinyi Chen, Binjiao Zheng.  (2025)  RSL3 Promotes STAT3 Ubiquitination to Induce Autophagy and Apoptosis in PARPi-Resistant Breast Cancer Cells.  Biomolecules,  15  (12): (1749).  [PMID:41463402] [10.3390/biom15121749]
95. Hu Xuewen, Zhou Tiantian, Cui Tiansi, Du Yuanjiao, Song Chunyu, Chang Weiping, Xiong Juan, Qin Jichao, Deng Lin, Ji Wei-Ke.  (2025)  SigmaR1 is an auxiliary translocon factor with lipid-binding activity that regulates protein and lipid droplet homeostasis.  Nature Communications,      [PMID:41476177] [10.1038/s41467-025-68157-7]
96. Anastasia Barsukova, Lei Zhao, Svetlana Trusova.  (2025)  Investigation of a phytaspase activity from Nicotiana benthamiana: purification, identification, and characterization.  Current Plant Biology,      [PMID:] [10.1016/j.cpb.2025.100487]
97. Tingting Ge, Hongyu Gao, Zhiran Zhang, Ling Qin, Tianbo Liu.  (2026)  aCBLC-mediated ubiquitin transfer from UBE2L6 to p53 accelerates ovarian cancer development.  Genes & Diseases,      [PMID:] [10.1016/j.gendis.2026.102044]
98. Ma Shuainan, Liu Qi, Han Wei, Liu Zhiyi, Jin Sinan, Wu He, Hua Wei.  (2026)  UBA52 Overexpression Ameliorates Intracerebral Hemorrhage-Associated Neuronal Apoptosis and Mitochondrial Dysfunction: A Protective Role in Neurons.  MOLECULAR NEUROBIOLOGY,  63  (1): (371).  [PMID:41553582] [10.1007/s12035-025-05655-1]
99. Ke Li, Zhengxiang Wang, Zaigang Zhou, Huan Ding, Sheng Wu, Yuan Li, Jianliang Shen.  (2026)  Mitochondria-Targeting Nanocuproptosis Breaks Immune Resistance.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202528750]
100. Baoqiong Liao, Meihuan Chen, Yun Huang, Mei Shuai, Liangpu Xu, Shuwen He, Hailong Huang.  (2026)  Emerging role of KDM5C in X-linked intellectual disability based on human genetic data and zebrafish models.  Frontiers in Molecular Neuroscience,      [PMID:41743791] [10.3389/fnmol.2026.1750311]
101. Zhao-Lei Ding, Yi-Chen Ma, Chuan-Mei Liu, Xiu Lu, Rong-Rong Wang, Min-Min Tang, Dong-Xu Hua, Ling Zheng, Hui Zhao, Lin Fu.  (2026)  1-Nitropyrene induces acute lung injury via SYVN1/Caspase-11-mediated apoptosis and pyroptosis in pulmonary epithelial cells.  Frontiers in Pharmacology,      [PMID:41737556] [10.3389/fphar.2026.1723593]
102. Xudong Li, Shiyu Zuo, Yanli Zhang, Zexing Liu, Na Shen, Qingqing Ma, Mingxia Sun, Binglei Zhang, Mengjia Li, Hong Huang, Mengya Gao, Zhenghua Huang, Huifang Zhao, Yilin Chen, Fengcai Gao, Wenjuan Fan, Zhen Zhang, Yuhan Hu, Yu An, Siyue Li, Miao Liu, Yupeng Liu, Yuxuan Liu, Chaoge Li, Yiguo Zhang, Yingmei Li, Weijie Cao, Fang Wang, Yongping Song, Linping Xu, Zhilei Bian, Wei Li.  (2026)  FBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.  Cell Reports Medicine,  (3):   [PMID:41850237] [10.1016/j.xcrm.2026.102686]
103. Yuhuan Jia, Qing Liang, Yi Zhang, Dan Zhao, Degang Zhao.  (2026)  Systematic characterization of ubiquitination modification of EuFPS1 in Eucommia ulmoides.  INDUSTRIAL CROPS AND PRODUCTS,      [PMID:] [10.1016/j.indcrop.2026.123057]
104. Jiaqi Li, Zhengxin Lu, Nan Zhang, Xiaowei Zhou, Yuanbiao Ma, Jia-qi Li, Yimu Zhang, Zhewen Deng, Na Lin, Peng Yue, Yilin Yang, Qi Zhang, Bo Ma.  (2026)  Andrographolide induces testicular damage by triggering ferroptosis in Sertoli cells via disruption of β-TrCP-mediated ATF4 ubiquitination and degradation.  CHEMICO-BIOLOGICAL INTERACTIONS,      [PMID:] [10.1016/j.cbi.2026.112052]
105. Meng Hui, Wang Zeyuan, Wang Liye, Fang Xiaokun, Li Haonan, Ma Weiqian, Ding Yi, Nan Manman, Meng Yu, Li Ling, Li Yizhen, Chen Kuisheng, Zhang Mingzhi.  (2026)  ZG16 represses tumor progression and M2 polarization of tumor-associated macrophages in hepatocellular carcinoma by promoting ubiquitination and degradation of SNX9 via binding to ITCH.  Hepatology International,      [PMID:41781795] [10.1007/s12072-026-11067-7]
106. Huang Yafei, Liu Hong, Tong Chao, Wang Zhimin, Xu Miaomiao, Dong Mengqi, Rao Rongjia, Wang Xianqiang, Feng Wei, Hu Zhan, Xu Fei, Zhao Wei, Wang Li, Hu Shengshou, Zhou Bingying.  (2026)  SIRT3 activation protects from nabumetone-induced mitochondrial toxicity in adult human cardiomyocytes.  CELLULAR AND MOLECULAR LIFE SCIENCES,      [PMID:] [10.1007/s00018-026-06142-z]
107. Huang Xinyun, Shi Huan, Shan Weiyan, Zhang Jingxia, Xu Qiaoping, Shang Hongkai.  (2026)  Pyruvate carboxylase promotes SREBP1a-mediated lipid synthesis in epithelial ovarian cancer.  Communications Biology,      [PMID:] [10.1038/s42003-026-10253-5]
108. Xu Gao, Xiaofeng Zhu, Yibin Lin, Chengkuan Liu, Qingwen Wang, Xian Lin.  (2026)  Targeting 5-methylcytosine RNA methylation–mediated CX26/IκBα/NF-κB signaling by salvianolic acid B attenuates rheumatoid arthritis progression.  PHYTOMEDICINE,      [PMID:] [10.1016/j.phymed.2026.158300]
109. Xiaoya Li, Xingyu Liu, Qinbin Ye, Shengchen Wang, Xiaoyu Xi, Jingyi Jiang, Xiaoshuang Mao, Meirong Fang, Wen Jin, Cheng Xiao.  (2026)  Erzhi Pill Enhances Methotrexate Efficacy in Rheumatoid Arthritis Bone Homeostasis via Activation of the IDO1-KYN-AhR Pathway.  PHYTOMEDICINE,      [PMID:] [10.1016/j.phymed.2026.158290]
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