DBCO-CONH-S-S-NHS ester - ≥97%, used for Antibody-Drug Conjugates (ADCs): Functions as a cleavable linker for attaching drugs to antibodies. Bioconjugation: Enables efficient molecular assembly through amine and click chemistry reactions. Protein Labeling

CAS: 1435934-53-4 Cat. No.: D648358 Formule: C₂₈H₂₇N₃O₆S₂ Poids moléculaire: 565.66 PubChem CID: 98233194

GRADE & PURITY ≥97%

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Vue d’ensemble

DBCO-CONH-S-S-COONHS Ester or DBCO-CONH-S-S-NHS ester is a cleavable heterobifunctional linker commonly used in bioconjugation and click chemistry. It features a DBCO group for strain-promoted azide-alkyne cycloaddition (SPAAC) and an NHS ester for coupling to primary amines. Its disulfide bond enables controlled cleavage under reductive conditions, thereby supporting applications in targeted drug delivery and molecular assembly.

Specifications

Spécifications et pureté

≥97%

Mécanismes biochimiques et physiologiques

DBCO-CONH-S-S-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Application

Antibody-Drug Conjugates (ADCs): Functions as a cleavable linker for attaching drugs to antibodies. Bioconjugation: Enables efficient molecular assembly through amine and click chemistry reactions. Protein Labeling: Facilitates protein labeling with vario

Conditions de stockage de stockage

Protected from light,Store at -20°C,Argon charged

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥97%

Noms et identifiants

• Sourires canoniques: C1CC(=O)N(C1=O)OC(=O)CCSSCCNC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 3-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]amino]ethyldisulfanyl]propanoate
• InChIKey: RPNGUSKTYYIUDE-UHFFFAOYSA-N
• INCHI: 1S/C28H27N3O6S2/c32-24(29-16-18-39-38-17-15-28(36)37-31-26(34)13-14-27(31)35)11-12-25(33)30-19-22-7-2-1-5-20(22)9-10-21-6-3-4-8-23(21)30/h1-8H,11-19H2,(H,29,32)
• Isomères SMILES: C1CC(=O)N(C1=O)OC(=O)CCSSCCNC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42
• PubChem CID: 98233194
• Poids moléculaire: 565.66

Propriétés chimiques et physiques

• Solubilité: DMSO : 100 mg/mL (176.78 mM; Need ultrasonic)
• Poids moléculaire: 565.700 g/mol
• XLogP3: 1.700
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 12
• Exact Mass: 565.134 Da
• Monoisotopic Mass: 565.134 Da
• Topological Polar Surface Area: 164.000 Ų
• Heavy Atom Count: 39
• Formal Charge: 0
• Complexity: 992.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1