Dehydroevodiamine hydrochloride - ≥99% , CAS No.111664-82-5

CAS: 111664-82-5 Cat. No.: D413069 Formule: C₁₉H₁₅N₃O.HCl Poids moléculaire: 337.8 Numéro CE: 112-522-7

QUALITÉ & PURETÉ ≥99%

Synonyms

Indolo[2',​3':3,​4]​pyrido[2,​1-​b]​quinazolin-​5(7H)​-​one,8,​14-​dihydro-​14-​methyl-​,hydrochloride (1:1)

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Information

Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibitAChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

Targets

AChE

In vitro

Dehydroevodiamine·HCl (DHED) treatment significantly recovers the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability. It decreases intracellular calcium levels in primary cortical neurons.

In vivo

Dehydroevodiamine·HCl (DHED) can improve stress-induced memory impairments and depression-like behaviors. DHED significantly improves learning and memory in the Aβ_1-42-infused rat model. Antiamnestic effects of DHED occur through an improvement of learning and memory and an inhibition of neuronal dysfunction in a scopolamine-induced amnesic rat model. Furthermore, Dehydroevodiamine·HCl (DHED) has hypotensive and neuroprotective effects and modulates nitric oxide production.

Cell Research(from reference)

Cell lines：primary cortical neurons 

Concentrations：0.5 and 1 µM 

Incubation Time：4 h 

Spécifications

Synonymes

Indolo[2',​3':3,​4]​pyrido[2,​1-​b]​quinazolin-​5(7H)​-​one,8,​14-​dihydro-​14-​methyl-​,hydrochloride (1:1)

Spécifications et pureté

≥99%

Mécanismes biochimiques et physiologiques

Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

Conditions de stockage de stockage

Protected from light,Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥99%

Propriétés du produit

ALogP

2.891

hba_count

2

Noms et identifiants

Sourires canoniques

Cl.CN1C2=CC=CC=C2C(=O)N3CCC4=C5C=CC=CC5=NC4=C13

Poids moléculaire

337.8

Reaxy-Rn

5326818

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5326818&ln=

Propriétés chimiques et physiques

• Solubilité: Solubility (25°C) In vitro DMSO: 37 mg/mL (109.53 mM)
• Sensibilité: light sensitive;Moisture sensitive
• DMSO (mg/mL) Solubilité maximale: 37
• DMSO (mM) Solubilité maximale: 109.5322676