Steroid hormone commonly used to induce hypertension in experimental animals. This form of hypertension is dependent on altered regulation of central pressor mechanisms including the brain renin-angiotensin system.
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This compound belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety.
External Descriptors
corticosteroid hormone
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3.Yuanyuan Xu, Younan Ren, Jie Zhang, Bo Niu, Mengru Liu, Tifei Xu, Xian Zhang, Jianhua Shen, Kai Wang, Zhengyu Cao. (2024) Discovery of pyridazinone derivatives bearing tetrahydroimidazo[1,2-a]pyrazine scaffold as potent inhibitors of transient receptor potential canonical 5 to ameliorate hypertension-induced renal injury in rats. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, [PMID:38878518][10.1016/j.ejmech.2024.116565]
4.Tingting Zhou, Zhiwei Wang, Xiaowang Lv, Mengting Guo, Ning Zhang, Liangju Liu, Li Geng, Jing Shao, Ka Zhang, Mengru Gao, Aiqin Mao, Yifei Zhu, Fan Yu, Lei Feng, Xiaoyan Wang, Qixiao Zhai, Wei Chen, Xin Ma. (2025) Targeting gut S. aureofaciens Tü117 serves as a new potential therapeutic intervention for the prevention and treatment of hypertension. Cell Metabolism, [PMID:39908987][10.1016/j.cmet.2025.01.004]
5.Long Xu, Xinyan Wu, Luosha Long, Suchun Li, Meiying Huang, Meng Li, Pinning Feng, Moshe Levi, Wei Chen, Lei Wang, Chunling Li, Weidong Wang. (2025) TGR5 attenuates DOCA-salt hypertension through regulating histone H3K4 methylation of ENaC in the kidney. METABOLISM-CLINICAL AND EXPERIMENTAL, [PMID:39824478][10.1016/j.metabol.2025.156133]
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